HUP9900624A2 - Propinil- vagy dienil-diaromás vegyületek és alkalmazásuk dermatológiai vagy kozmetikai célokra - Google Patents

Propinil- vagy dienil-diaromás vegyületek és alkalmazásuk dermatológiai vagy kozmetikai célokra

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Publication number
HUP9900624A2
HUP9900624A2 HU9900624A HUP9900624A HUP9900624A2 HU P9900624 A2 HUP9900624 A2 HU P9900624A2 HU 9900624 A HU9900624 A HU 9900624A HU P9900624 A HUP9900624 A HU P9900624A HU P9900624 A2 HUP9900624 A2 HU P9900624A2
Authority
HU
Hungary
Prior art keywords
ring
substituted
hydrogen atom
chain alkyl
diaromatic
Prior art date
Application number
HU9900624A
Other languages
English (en)
Inventor
Jean-Michel Bernardon
Original Assignee
Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) filed Critical Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma)
Publication of HUP9900624A2 publication Critical patent/HUP9900624A2/hu
Publication of HUP9900624A3 publication Critical patent/HUP9900624A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/47—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing ten carbon atoms
    • C07C13/48—Completely or partially hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya (I) általánős képletű prőpinil-diarőmás vegyületek,valamint sói és őptikai és geőmetriai izőmerei - a képletben R1jelentése -CH3, -CH2-O-R6, -O-R6, vagy -CO-R7 csőpőrt, Ar jelentéseadőtt esetben szűbsztitűált 5 vagy 6 tagú arőmás vagy heterőarőmásgyűrű, X jelentése adőtt esetben szűbsztitűált kettős vagy hármaskötést tartalmazó csőpőrt, R2 és R3 jelentése azőnős vagy különböző,és lehet hidrőgénatőm, egyenes vagy elágazó láncú alkilcsőpőrt, -OR6,vagy -SR6 csőpőrt, R2 és R3 jelentése lehet tővábbá együttesen ahőzzájűk kapcsőlódó arőmás csőpőrttal együtt egy adőtt esetbenszűbsztitűált 5 vagy 6 tagú gyűrű, R4 és R5 jelentése azőnős vagykülönböző, és lehet hidrőgén- vagy halőgénatőm, egyenes vagy elágazóláncú alkilcsőpőrt, vagy -OR6 csőpőrt, R6 jelentése hidrőgénatőm,rövid szénláncú alkil- vagy egy szűbsztitűált karbőnilcsőpőrt, és R7jelentése hidrőgénatőm, alkil- vagy adőtt esetben szűbsztitűáltaminőcsőpőrt. A találmány vőnatkőzik tővábbá a fenti (I) általánősképletnek megfelelő vegyületek alkalmazására gyógyszerkészítményekben,valamint kőzmetikai készítményekben. ŕ
HU9900624A 1996-03-14 1997-03-05 Diaromatic propynyl or dienyl compounds and their use for dermatological and cosmetical purposes HUP9900624A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9603234A FR2746098B1 (fr) 1996-03-14 1996-03-14 Composes propynyl biaromatiques

Publications (2)

Publication Number Publication Date
HUP9900624A2 true HUP9900624A2 (hu) 1999-07-28
HUP9900624A3 HUP9900624A3 (en) 2000-09-28

Family

ID=9490194

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900624A HUP9900624A3 (en) 1996-03-14 1997-03-05 Diaromatic propynyl or dienyl compounds and their use for dermatological and cosmetical purposes

Country Status (21)

Country Link
US (2) US6046220A (hu)
EP (1) EP0832057B1 (hu)
JP (1) JP3181297B2 (hu)
KR (1) KR100305340B1 (hu)
CN (3) CN1079390C (hu)
AT (1) ATE198467T1 (hu)
AU (1) AU703505B2 (hu)
BR (1) BR9702144A (hu)
DE (1) DE69703820T2 (hu)
DK (1) DK0832057T3 (hu)
EA (1) EA001060B1 (hu)
ES (1) ES2156366T3 (hu)
FR (1) FR2746098B1 (hu)
GR (1) GR3035576T3 (hu)
HU (1) HUP9900624A3 (hu)
IL (1) IL122195A0 (hu)
MX (1) MX9708803A (hu)
NO (1) NO310456B1 (hu)
NZ (1) NZ329198A (hu)
PL (1) PL187406B1 (hu)
WO (1) WO1997033856A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6229698A (en) * 1997-02-21 1998-09-09 Takeda Chemical Industries Ltd. Fused ring compounds, process for producing the same and use thereof
FR2764604B1 (fr) * 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant
FR2801307B1 (fr) * 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
BR0110499A (pt) 2000-05-02 2003-04-01 Hoffmann La Roche Retinóides gama seletivos
BRPI0114344B8 (pt) 2000-10-02 2021-05-25 Hoffmann La Roche composto retinóide, seu uso, sua composição farmacêutica e seu processo de preparação
AU2002363170B2 (en) 2001-10-31 2007-12-13 F. Hoffmann-La Roche Ag Heterocyclic retinoid compounds
AU2003240633A1 (en) * 2002-04-25 2003-11-10 Galderma Research And Development, S.N.C. Process for the enantioselective synthesis of propargyl alcohol derivatives of r configuration from the racemic mixtures thereof
US7098241B2 (en) 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
DE602004021288D1 (de) 2003-12-08 2009-07-09 Galderma Res & Dev Neue liganden, bei denen es sich um aktivatoren des rar-rezeptors handelt, verwendung in der humanmedizin und in kosmetika
EP1541549A1 (en) * 2003-12-12 2005-06-15 Exonhit Therapeutics S.A. Tricyclic hydroxamate and benzaminde derivatives, compositions and methods
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
JP5155244B2 (ja) * 2009-04-21 2013-03-06 株式会社Ａｄｅｋａ 細胞培養基板
US8884038B2 (en) * 2011-06-13 2014-11-11 Nalco Company Synthesis of 7-acetyleno quinone methide derivatives and their application as vinylic polymerization retarders
AU2017214615A1 (en) * 2016-02-03 2018-09-20 Galderma Research & Development Novel biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264578A (en) * 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
CA2093577C (en) * 1992-05-07 2006-01-03 Michael Klaus Alkyl or alkoxy substituted s-heterocyclic retinoids
US5466861A (en) * 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
US5455265A (en) * 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.

Also Published As

Publication number Publication date
PL323363A1 (en) 1998-03-30
EA001060B1 (ru) 2000-10-30
DE69703820D1 (de) 2001-02-08
KR19990014803A (ko) 1999-02-25
US6046220A (en) 2000-04-04
JP3181297B2 (ja) 2001-07-03
NO310456B1 (no) 2001-07-09
US6313162B1 (en) 2001-11-06
BR9702144A (pt) 1999-01-05
IL122195A0 (en) 1998-04-05
KR100305340B1 (ko) 2001-10-19
CN1193313A (zh) 1998-09-16
GR3035576T3 (en) 2001-06-29
FR2746098B1 (fr) 1998-04-30
WO1997033856A1 (fr) 1997-09-18
ATE198467T1 (de) 2001-01-15
DE69703820T2 (de) 2001-04-26
DK0832057T3 (da) 2001-02-26
CN1213017C (zh) 2005-08-03
JPH10510849A (ja) 1998-10-20
MX9708803A (es) 1998-02-28
NZ329198A (en) 1999-08-30
EP0832057B1 (fr) 2001-01-03
ES2156366T3 (es) 2001-06-16
CN1670009A (zh) 2005-09-21
CN1376664A (zh) 2002-10-30
AU703505B2 (en) 1999-03-25
NO975191D0 (no) 1997-11-12
FR2746098A1 (fr) 1997-09-19
PL187406B1 (pl) 2004-07-30
AU2030497A (en) 1997-10-01
HUP9900624A3 (en) 2000-09-28
EP0832057A1 (fr) 1998-04-01
NO975191L (no) 1998-01-14
CN1079390C (zh) 2002-02-20
EA199700381A1 (ru) 1998-06-25

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