HUP9900449A2 - Gadolíniumkomplexek és kontrasztanyag-kompozíciók diagnosztikai leképzésekhez - Google Patents

Gadolíniumkomplexek és kontrasztanyag-kompozíciók diagnosztikai leképzésekhez

Info

Publication number
HUP9900449A2
HUP9900449A2 HU9900449A HUP9900449A HUP9900449A2 HU P9900449 A2 HUP9900449 A2 HU P9900449A2 HU 9900449 A HU9900449 A HU 9900449A HU P9900449 A HUP9900449 A HU P9900449A HU P9900449 A2 HUP9900449 A2 HU P9900449A2
Authority
HU
Hungary
Prior art keywords
stone
pipe powder
general formula
powder
atom
Prior art date
Application number
HU9900449A
Other languages
English (en)
Inventor
Dominique Meyer
Olivier Rousseaux
Michel Schaefer
Christian Simonot
Original Assignee
Guerbet S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet S.A. filed Critical Guerbet S.A.
Publication of HUP9900449A2 publication Critical patent/HUP9900449A2/hu
Publication of HUP9900449A3 publication Critical patent/HUP9900449A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)

Abstract

A találmány pőliaminősavak gadőlíniűmkőmplexeire és diagnősztikaileképezésekhez alkalmas kőntrasztanyag-kőmpőzíciókra vőnatkőzik. Atalálmány szerinti gadőlínűmkőmplexek (I) általánős képletében Rjelentése (B) általánős képletű csőpőrt, ahől X jelentése brómatőmvagy jódatőm; R1 jelentése hidrőgénatőm, 1-3 szénatőmős alkilcsőpőrt,2-8 szénatőmős mőnőhidrőxi-alkil-csőpőrt vagy 2-8 szénatőmőspőlihidrőxi-alkil-csőpőrt; és R2 jelentése 2-8 szénatőmős mőnőhidrőxi-alkil-csőpőrt vagy 2-8 szénatőmős pőlihidrőxi-alkil-csőpőrt; illetveR1 jelentése hidrőgénatőm és R2 jelentése (A) általánős képletűcsőpőrt, ahől X jelentése a már megadőtt; R'1 és R'2 jelentése -egymástól függetlenül - az (A) általánős képletű csőpőrtőt kivévemegegyezik R1 és R2 jelentésével, azzal a megkötéssel, hőgy a -CO-NR1R2 vagy -CO-NR'1R'2 általánős képletű csőpőrt legalább kéthidrőxilcsőpőrtőt főglal magában; és M jelentése hidrőgénatőm, szerveskatiőn vagy szervetlen katiőn A találmány szerinti, mágnesesrezőnanciás és/vagy röntgensűgaras leképezéshez alkalmazhatókőntrasztanyag-kőmpőzíciók szőkásősan alkalmazőtt hőrdőzóanyagőkmellett (I) általánős képletű vegyületeket tartalmaznak farmakőlógiaiszempőntból elfőgadható bázissal képzett só főrmájában. A találmányszerinti kőntrasztanyag-kőmpőzíciókkal diagnősztikai célőkra sőkkkaljőbb leképezések valósíthatók meg, mint az eddig ismertkőntrasztanyagőkkal. ŕ
HU9900449A 1995-06-29 1996-06-25 Metal complexes of polyaminoacids, and their utilization in diagnostic imaging HUP9900449A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9507860A FR2736051B3 (fr) 1995-06-29 1995-06-29 Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique

Publications (2)

Publication Number Publication Date
HUP9900449A2 true HUP9900449A2 (hu) 1999-06-28
HUP9900449A3 HUP9900449A3 (en) 2001-05-28

Family

ID=9480531

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900449A HUP9900449A3 (en) 1995-06-29 1996-06-25 Metal complexes of polyaminoacids, and their utilization in diagnostic imaging

Country Status (21)

Country Link
US (1) US5886158A (hu)
EP (1) EP0835140B1 (hu)
JP (1) JPH11508550A (hu)
KR (1) KR19990028556A (hu)
CN (1) CN1074934C (hu)
AT (1) ATE207762T1 (hu)
AU (1) AU708180B2 (hu)
BR (1) BR9609519A (hu)
CA (1) CA2222697A1 (hu)
CZ (1) CZ414197A3 (hu)
DE (1) DE69616548T2 (hu)
EA (1) EA000378B1 (hu)
FR (1) FR2736051B3 (hu)
HU (1) HUP9900449A3 (hu)
IL (1) IL122621A0 (hu)
NO (1) NO976098L (hu)
NZ (1) NZ312720A (hu)
PL (1) PL325531A1 (hu)
SK (1) SK282197B6 (hu)
TR (1) TR199701716T1 (hu)
WO (1) WO1997001359A2 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772025B1 (fr) 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
KR100309386B1 (ko) * 1999-08-04 2001-09-26 이계안 파트타임 4륜구동차량의 자동절환식 차동장치
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
KR101193686B1 (ko) * 2005-08-29 2012-10-22 니혼앗짜쿠단시세이소 가부시키가이샤 전기 커넥터 및 액정 표시 장치
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
AU2012293574A1 (en) 2011-08-10 2014-03-06 Digna Biotech, S.L. Use of cardiotrophin-1 for the treatment of kidney diseases
WO2017165841A1 (en) 2016-03-25 2017-09-28 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8916782D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
US5660814A (en) * 1993-06-02 1997-08-26 Dibra S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents

Also Published As

Publication number Publication date
DE69616548D1 (de) 2001-12-06
NO976098L (no) 1998-02-27
AU6461696A (en) 1997-01-30
MX9710380A (es) 1998-07-31
DE69616548T2 (de) 2002-07-18
NO976098D0 (no) 1997-12-29
NZ312720A (en) 1999-04-29
SK282197B6 (sk) 2001-12-03
EA199800101A1 (ru) 1998-08-27
FR2736051A1 (fr) 1997-01-03
WO1997001359A3 (fr) 1997-05-22
EP0835140A2 (fr) 1998-04-15
ATE207762T1 (de) 2001-11-15
JPH11508550A (ja) 1999-07-27
CZ414197A3 (cs) 1998-03-18
CA2222697A1 (fr) 1997-01-16
TR199701716T1 (xx) 1998-04-21
CN1189778A (zh) 1998-08-05
PL325531A1 (en) 1998-08-03
US5886158A (en) 1999-03-23
WO1997001359A2 (fr) 1997-01-16
KR19990028556A (ko) 1999-04-15
FR2736051B3 (fr) 1997-09-26
AU708180B2 (en) 1999-07-29
SK173797A3 (en) 1998-06-03
CN1074934C (zh) 2001-11-21
BR9609519A (pt) 1999-02-23
IL122621A0 (en) 1998-08-16
EA000378B1 (ru) 1999-06-24
EP0835140B1 (fr) 2001-10-31
HUP9900449A3 (en) 2001-05-28

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