ES8107159A1 - Un procedimiento para preparar sales de lisina y arginina del acido 5-(2,4-difluorofenil)-2-hidroxibenzoico - Google Patents

Un procedimiento para preparar sales de lisina y arginina del acido 5-(2,4-difluorofenil)-2-hidroxibenzoico

Info

Publication number
ES8107159A1
ES8107159A1 ES495899A ES495899A ES8107159A1 ES 8107159 A1 ES8107159 A1 ES 8107159A1 ES 495899 A ES495899 A ES 495899A ES 495899 A ES495899 A ES 495899A ES 8107159 A1 ES8107159 A1 ES 8107159A1
Authority
ES
Spain
Prior art keywords
difluorophenyl
pharmaceutical compositions
arginine
lysine
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495899A
Other languages
English (en)
Other versions
ES495899A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Resfar Srl
Original Assignee
Resfar Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resfar Srl filed Critical Resfar Srl
Publication of ES8107159A1 publication Critical patent/ES8107159A1/es
Publication of ES495899A0 publication Critical patent/ES495899A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE SALES DE LISINA Y ARGININA DEL ACIDO 5-(2,4-DIFLUOROFENIL)-2-HIDROXIBENZOICO, DE FORMULA (I), EN LA QUE X ES UN RADICAL -CH2- O -C(NH)-NH-. SE BASA EN LA REACCION DE NEUTRALIZACION DE ACIDO 5-(2,4-DIFLUOROFENIL)-2-HIDROXIBENZOICO CON UN AMINOACIDO DE FORMULA (II), EN LA QUE X ES LO MISMO QUE EN LA FORMULA (I). EL ACIDO, QUE ES INSOLUBLE EN AGUA, SE AÑADE EN FORMA SOLIDA EN PEQUEÑAS PORCIONES A LA DISOLUCION ACUOSA DEL AMINOACIDO, EN PROPORCION ESTEQUIOMETRICA. EL PRODUCTO OBTENIDO SE SEPARA Y PURIFICA POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANALGESICAS Y ANTIINFLAMATORIAS. *FORMULA*
ES495899A 1979-10-15 1980-10-14 Un procedimiento para preparar sales de lisina y arginina del acido 5-(2,4-difluorofenil)-2-hidroxibenzoico Granted ES495899A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26507/79A IT1166912B (it) 1979-10-15 1979-10-15 Derivati ad attivita' antidolorifica, antipiretica, antinfiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche con tenenti detti derivati

Publications (2)

Publication Number Publication Date
ES8107159A1 true ES8107159A1 (es) 1981-09-16
ES495899A0 ES495899A0 (es) 1981-09-16

Family

ID=11219667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495899A Granted ES495899A0 (es) 1979-10-15 1980-10-14 Un procedimiento para preparar sales de lisina y arginina del acido 5-(2,4-difluorofenil)-2-hidroxibenzoico

Country Status (6)

Country Link
JP (1) JPS5677240A (es)
DE (1) DE3037598C2 (es)
ES (1) ES495899A0 (es)
FR (1) FR2467188A1 (es)
GB (1) GB2060638B (es)
IT (1) IT1166912B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3328401A1 (de) * 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH503689A (de) * 1967-03-09 1971-02-28 Merck & Co Inc Verfahren zur Herstellung von Phenyl-benzoesäure-Verbindungen

Also Published As

Publication number Publication date
FR2467188A1 (fr) 1981-04-17
GB2060638A (en) 1981-05-07
JPS6116380B2 (es) 1986-04-30
GB2060638B (en) 1983-09-28
FR2467188B1 (es) 1982-10-29
DE3037598A1 (de) 1981-04-23
JPS5677240A (en) 1981-06-25
ES495899A0 (es) 1981-09-16
IT7926507A0 (it) 1979-10-15
IT1166912B (it) 1987-05-06
DE3037598C2 (de) 1983-09-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612