HUP9900186A2 - Lamellarin alkaloidok gyógyászati alkalmazása és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Lamellarin alkaloidok gyógyászati alkalmazása és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9900186A2
HUP9900186A2 HU9900186A HUP9900186A HUP9900186A2 HU P9900186 A2 HUP9900186 A2 HU P9900186A2 HU 9900186 A HU9900186 A HU 9900186A HU P9900186 A HUP9900186 A HU P9900186A HU P9900186 A2 HUP9900186 A2 HU P9900186A2
Authority
HU
Hungary
Prior art keywords
lamellarin
alkaloids
therapy
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9900186A
Other languages
English (en)
Inventor
Delores Garcia Gravalos
Jose Luis Fernandez Puentes
Ana Rodriguez Quesada
Original Assignee
Pharma Mar, S.A. .
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar, S.A. . filed Critical Pharma Mar, S.A. .
Publication of HUP9900186A2 publication Critical patent/HUP9900186A2/hu
Publication of HUP9900186A3 publication Critical patent/HUP9900186A3/hu
Publication of HU225588B1 publication Critical patent/HU225588B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coating Apparatus (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgyát az (A) és (B) általánős képletűlamellarinszármazékők alkalmazása képezi őlyan gyógyászatikészítmények előállítására, amelyek eredményesen alkalmazhatók többgyógyszerrel szemben rezisztenciát műtató daganatős betegségekkezelésére. Az (A) és (B) általánős képletben R1-R17 jelentésehidrőgénatőm, hidrőxil-, metil-, etil-, prőpil-, metőxi-, metil-karbőnil- vagy metil-karbőnil-őxi-csőpőrt. A találmány tárgyát képezikazőn gyógyászati készítmények is, amelyek (A) és/vagy (B) általánősképletű lamellarinszármazékőt és adőtt esetben őlyan gyógyszerttartalmaznak, amelyek gyógyszerrezisztencia révén kőrlátőzőtt hatástműtatnak. ŕ
HU9900186A 1995-06-29 1996-06-26 Use of lamellarin alkaloids in therapy and pharmaceutical compositions containing them HU225588B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/496,465 US5852033A (en) 1995-06-29 1995-06-29 Methods of treatment using lamellarin-class alkaloids
PCT/IB1996/000742 WO1997001336A1 (en) 1995-06-29 1996-06-26 Use of lamellarin-class alkaloids in methods of treatment

Publications (3)

Publication Number Publication Date
HUP9900186A2 true HUP9900186A2 (hu) 1999-06-28
HUP9900186A3 HUP9900186A3 (en) 2001-08-28
HU225588B1 HU225588B1 (en) 2007-03-28

Family

ID=23972747

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900186A HU225588B1 (en) 1995-06-29 1996-06-26 Use of lamellarin alkaloids in therapy and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (2) US5852033A (hu)
EP (1) EP0835108B1 (hu)
JP (1) JP4153992B2 (hu)
AT (1) ATE208196T1 (hu)
AU (1) AU700420B2 (hu)
CA (1) CA2225807C (hu)
DE (1) DE69616792T2 (hu)
DK (1) DK0835108T3 (hu)
ES (1) ES2164899T3 (hu)
HU (1) HU225588B1 (hu)
MX (1) MX9800248A (hu)
PL (1) PL184667B1 (hu)
PT (1) PT835108E (hu)
RU (1) RU2188637C2 (hu)
WO (1) WO1997001336A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852033A (en) * 1995-06-29 1998-12-22 Pharma Mar, S.A. Methods of treatment using lamellarin-class alkaloids
AUPO656597A0 (en) * 1997-05-02 1997-05-29 Australian National University, The Preparation of therapeutic compounds
US6248752B1 (en) * 1998-02-27 2001-06-19 Charles Duane Smith Azabicyclooctane compositions and methods for enhancing chemotherapy
AUPP433398A0 (en) * 1998-06-25 1998-07-16 Australian National University, The Compounds and processes
GB9920912D0 (en) * 1999-09-03 1999-11-10 Indena Spa Novel derivatives of flavones,xanthones and coumarins
WO2001064635A1 (en) * 2000-03-01 2001-09-07 The Scripps Research Institute Ningalin b analogs employable for reversing multidrug resistance
US6989396B2 (en) 2001-04-12 2006-01-24 The Board Of Trustees Of The University Of Illinois Tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and use of the same
CA2465886A1 (en) * 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US20060040945A1 (en) * 2002-05-17 2006-02-23 Merckle Gmbh Annellated pyrrole compounds as proton pump inhibitors for treating ulcer
MXPA04011097A (es) * 2002-05-17 2005-02-14 Merckle Gmbh Compuestos de pirrol recocidos como inhibidores de la bomba de protones para tratar ulceras.
GB0218816D0 (en) * 2002-08-13 2002-09-18 Pharma Mar Sa Antitumoral analogs of lamellarins
WO2006026496A2 (en) * 2004-08-27 2006-03-09 Memorial Sloan-Kettering Cancer Center Immunosuppressive ningalin compounds
WO2012099129A1 (ja) * 2011-01-17 2012-07-26 国立大学法人 長崎大学 抗癌活性化合物
EP3604312B1 (en) * 2017-03-29 2023-11-29 Nagasaki University Fourth-generation egfr tyrosine kinase inhibitor
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
RU2745401C1 (ru) * 2020-07-13 2021-03-24 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "Институт биологии южных морей имени А.О. Ковалевского РАН" (ФИЦ ИнБЮМ) Способ индукции секреции биологически активных соединений у рапаны rapana venosa val.
CN112300232B (zh) * 2020-11-03 2021-11-09 浙江大学 Lamellarin D糖基化衍生物及其制备和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852033A (en) * 1995-06-29 1998-12-22 Pharma Mar, S.A. Methods of treatment using lamellarin-class alkaloids

Also Published As

Publication number Publication date
RU2188637C2 (ru) 2002-09-10
ATE208196T1 (de) 2001-11-15
US6087370A (en) 2000-07-11
AU700420B2 (en) 1999-01-07
PL324282A1 (en) 1998-05-11
MX9800248A (es) 1998-11-30
AU6316796A (en) 1997-01-30
PT835108E (pt) 2002-03-28
HU225588B1 (en) 2007-03-28
JP4153992B2 (ja) 2008-09-24
PL184667B1 (pl) 2002-11-29
CA2225807A1 (en) 1997-01-16
CA2225807C (en) 2008-04-22
DE69616792D1 (de) 2001-12-13
EP0835108A1 (en) 1998-04-15
ES2164899T3 (es) 2002-03-01
WO1997001336A1 (en) 1997-01-16
DE69616792T2 (de) 2002-06-20
US5852033A (en) 1998-12-22
HUP9900186A3 (en) 2001-08-28
DK0835108T3 (da) 2002-03-18
JPH11508882A (ja) 1999-08-03
EP0835108B1 (en) 2001-11-07

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