CA2225807A1 - Use of lamellarin-class alkaloids in methods of treatment - Google Patents
Use of lamellarin-class alkaloids in methods of treatmentInfo
- Publication number
- CA2225807A1 CA2225807A1 CA002225807A CA2225807A CA2225807A1 CA 2225807 A1 CA2225807 A1 CA 2225807A1 CA 002225807 A CA002225807 A CA 002225807A CA 2225807 A CA2225807 A CA 2225807A CA 2225807 A1 CA2225807 A1 CA 2225807A1
- Authority
- CA
- Canada
- Prior art keywords
- mdr
- lamellarin
- found
- treatment
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930013930 alkaloid Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229930190794 lamellarin Natural products 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 2
- 230000001472 cytotoxic effect Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 102000012750 Membrane Glycoproteins Human genes 0.000 abstract 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 230000001675 anti-mdr Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Coating Apparatus (AREA)
Abstract
The lamellarin compounds disclosed herein have been found to be inhibitors of MDR, i.e., acquired multidrug resistance, which has become a major problem in the treatment of various cancers. The lamellarin compounds disclosed herein have also been found to be cytotoxic to MDR cells. MDR is believed to be associated with certain alterations in tumor cells, including an over-expression of a certain high molecular weight membrane glycoprotein and a decrease in the ability of the tumor cell to accumulate and retain chemotherapeutic agents. The present invention is thus directed to methods of treating MDR-type tumors with an effective anti-MDR amount (either inhibitory or cytotoxic) of one or more lamellarin compounds, which compounds have been found to be effective antitumoral agents against MDR
cells.
cells.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/496,465 US5852033A (en) | 1995-06-29 | 1995-06-29 | Methods of treatment using lamellarin-class alkaloids |
| US08/496,465 | 1995-06-29 | ||
| PCT/IB1996/000742 WO1997001336A1 (en) | 1995-06-29 | 1996-06-26 | Use of lamellarin-class alkaloids in methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2225807A1 true CA2225807A1 (en) | 1997-01-16 |
| CA2225807C CA2225807C (en) | 2008-04-22 |
Family
ID=23972747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002225807A Expired - Fee Related CA2225807C (en) | 1995-06-29 | 1996-06-26 | Use of lamellarin-class alkaloids in methods of treatment |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5852033A (en) |
| EP (1) | EP0835108B1 (en) |
| JP (1) | JP4153992B2 (en) |
| AT (1) | ATE208196T1 (en) |
| AU (1) | AU700420B2 (en) |
| CA (1) | CA2225807C (en) |
| DE (1) | DE69616792T2 (en) |
| DK (1) | DK0835108T3 (en) |
| ES (1) | ES2164899T3 (en) |
| HU (1) | HU225588B1 (en) |
| MX (1) | MX9800248A (en) |
| PL (1) | PL184667B1 (en) |
| PT (1) | PT835108E (en) |
| RU (1) | RU2188637C2 (en) |
| WO (1) | WO1997001336A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852033A (en) * | 1995-06-29 | 1998-12-22 | Pharma Mar, S.A. | Methods of treatment using lamellarin-class alkaloids |
| AUPO656597A0 (en) * | 1997-05-02 | 1997-05-29 | Australian National University, The | Preparation of therapeutic compounds |
| US6248752B1 (en) * | 1998-02-27 | 2001-06-19 | Charles Duane Smith | Azabicyclooctane compositions and methods for enhancing chemotherapy |
| AUPP433398A0 (en) * | 1998-06-25 | 1998-07-16 | Australian National University, The | Compounds and processes |
| GB9920912D0 (en) * | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
| US7250409B2 (en) * | 2000-03-01 | 2007-07-31 | The Scripps Research Institute | Ningalin B analogs employable for reversing multidrug resistance |
| US6989396B2 (en) | 2001-04-12 | 2006-01-24 | The Board Of Trustees Of The University Of Illinois | Tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and use of the same |
| US20030109448A1 (en) * | 2001-11-07 | 2003-06-12 | Crowley Kathleen S. | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| PT1505964E (en) * | 2002-05-17 | 2008-02-28 | Merckle Gmbh | Annelated pyrrole compounds as proton pump inhibitors for treating ulcer |
| US20060040945A1 (en) * | 2002-05-17 | 2006-02-23 | Merckle Gmbh | Annellated pyrrole compounds as proton pump inhibitors for treating ulcer |
| GB0218816D0 (en) * | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | Antitumoral analogs of lamellarins |
| US8138170B2 (en) * | 2004-08-27 | 2012-03-20 | Memorial Sloan-Kettering Cancer Center | Immunosuppressive Ningalin compounds |
| JP5888702B2 (en) * | 2011-01-17 | 2016-03-22 | 国立大学法人 長崎大学 | Anticancer active compound |
| WO2018181777A1 (en) * | 2017-03-29 | 2018-10-04 | 国立大学法人 長崎大学 | Fourth-generation egfr tyrosine kinase inhibitor |
| JOP20190254A1 (en) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | Antitumoral compounds |
| RU2745401C1 (en) * | 2020-07-13 | 2021-03-24 | Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "Институт биологии южных морей имени А.О. Ковалевского РАН" (ФИЦ ИнБЮМ) | Method for inducing the secretion of biologically active compounds in sea snail rapana venosa val. |
| CN112300232B (en) * | 2020-11-03 | 2021-11-09 | 浙江大学 | Lamelarin D glycosylated derivative and preparation and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852033A (en) * | 1995-06-29 | 1998-12-22 | Pharma Mar, S.A. | Methods of treatment using lamellarin-class alkaloids |
-
1995
- 1995-06-29 US US08/496,465 patent/US5852033A/en not_active Expired - Fee Related
-
1996
- 1996-06-26 JP JP50428597A patent/JP4153992B2/en not_active Expired - Fee Related
- 1996-06-26 HU HU9900186A patent/HU225588B1/en not_active IP Right Cessation
- 1996-06-26 AT AT96922197T patent/ATE208196T1/en not_active IP Right Cessation
- 1996-06-26 DK DK96922197T patent/DK0835108T3/en active
- 1996-06-26 PT PT96922197T patent/PT835108E/en unknown
- 1996-06-26 RU RU98101364/14A patent/RU2188637C2/en not_active IP Right Cessation
- 1996-06-26 WO PCT/IB1996/000742 patent/WO1997001336A1/en active IP Right Grant
- 1996-06-26 EP EP96922197A patent/EP0835108B1/en not_active Expired - Lifetime
- 1996-06-26 ES ES96922197T patent/ES2164899T3/en not_active Expired - Lifetime
- 1996-06-26 AU AU63167/96A patent/AU700420B2/en not_active Ceased
- 1996-06-26 PL PL96324282A patent/PL184667B1/en not_active IP Right Cessation
- 1996-06-26 CA CA002225807A patent/CA2225807C/en not_active Expired - Fee Related
- 1996-06-26 DE DE69616792T patent/DE69616792T2/en not_active Expired - Fee Related
-
1998
- 1998-01-07 MX MX9800248A patent/MX9800248A/en not_active IP Right Cessation
- 1998-12-18 US US09/216,406 patent/US6087370A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU6316796A (en) | 1997-01-30 |
| CA2225807C (en) | 2008-04-22 |
| WO1997001336A1 (en) | 1997-01-16 |
| DE69616792T2 (en) | 2002-06-20 |
| HUP9900186A3 (en) | 2001-08-28 |
| PL324282A1 (en) | 1998-05-11 |
| RU2188637C2 (en) | 2002-09-10 |
| AU700420B2 (en) | 1999-01-07 |
| MX9800248A (en) | 1998-11-30 |
| DK0835108T3 (en) | 2002-03-18 |
| ES2164899T3 (en) | 2002-03-01 |
| EP0835108A1 (en) | 1998-04-15 |
| HUP9900186A2 (en) | 1999-06-28 |
| EP0835108B1 (en) | 2001-11-07 |
| PL184667B1 (en) | 2002-11-29 |
| JPH11508882A (en) | 1999-08-03 |
| US5852033A (en) | 1998-12-22 |
| US6087370A (en) | 2000-07-11 |
| ATE208196T1 (en) | 2001-11-15 |
| HU225588B1 (en) | 2007-03-28 |
| DE69616792D1 (en) | 2001-12-13 |
| PT835108E (en) | 2002-03-28 |
| JP4153992B2 (en) | 2008-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |