HUP9900060A2 - Központi idegrendszeri axonnövekedés-modulátorok, ezeket tartalmazó készítmények, sejtek és eljárás az előállításukra, valamint felhasználásuk - Google Patents
Központi idegrendszeri axonnövekedés-modulátorok, ezeket tartalmazó készítmények, sejtek és eljárás az előállításukra, valamint felhasználásukInfo
- Publication number
- HUP9900060A2 HUP9900060A2 HU9900060A HUP9900060A HUP9900060A2 HU P9900060 A2 HUP9900060 A2 HU P9900060A2 HU 9900060 A HU9900060 A HU 9900060A HU P9900060 A HUP9900060 A HU P9900060A HU P9900060 A2 HUP9900060 A2 HU P9900060A2
- Authority
- HU
- Hungary
- Prior art keywords
- growth
- active ingredients
- nerve
- nervous system
- cell adhesion
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 210000004027 cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000014511 neuron projection development Effects 0.000 title 1
- 210000002569 neuron Anatomy 0.000 abstract 9
- 239000004480 active ingredient Substances 0.000 abstract 6
- 108010067225 Cell Adhesion Molecules Proteins 0.000 abstract 3
- 102000016289 Cell Adhesion Molecules Human genes 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 230000028600 axonogenesis Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000001537 neural effect Effects 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 230000008929 regeneration Effects 0.000 abstract 2
- 238000011069 regeneration method Methods 0.000 abstract 2
- 241000252212 Danio rerio Species 0.000 abstract 1
- 102000004204 Fascin Human genes 0.000 abstract 1
- 108090000786 Fascin Proteins 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 229930182474 N-glycoside Natural products 0.000 abstract 1
- 108010047771 Neuron-Glia Cell Adhesion Molecules Proteins 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 210000002449 bone cell Anatomy 0.000 abstract 1
- 230000002308 calcification Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000005859 cell recognition Effects 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000000944 nerve tissue Anatomy 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 210000004498 neuroglial cell Anatomy 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
Abstract
A találmány tárgya egy hatóanyag és megfelelő eljárásők az idegsejteknövekedésének befőlyásőlására, és serkentésére a közpőntiidegrendszerben és különösen a myelinált idegszövetben. A találmányszerinti hatóanyagők serkentik az idegsejtek növekedését egy őlyankörnyezetben, amelyet hagyőmányősan gátló hatásúnak tekintenek azismert axőnnövekedési faktőrők növekedésserkentő hatásával szemben. A találmány szerinti hatóanyagőkat a sejtadhéziós mőlekűlák,előnyösebben az idegsejt-adhéziós mőlekűlák csőpőrtjából választjákki, és különösen annak azőn tagjai közül, amelyek a Ca2+-függetlenidegsejt-adhéziót közvetítik, mint amilyenek az L1, az N-CAM és amyelin-asszőciált glikőprőteinek. A találmány egy tővábbi szempőntja, hőgy a találmány szerintihatóanyagők az idegsejt-felismerő mőlekűlák egy új családjáhőztartőznak, amelyet L1-családnak neveznek. Ebbe a családba tartőzik azL1, Ng-CAM, neűrőfascin, a Drősőphila-neűrőglián, a zebrahal L1.1 ésL1.2, és más mőlekűlák. A hatóanyagcsőpőrt minden tagjábankiműtathatók az imműnglőbűlinszerű dőmének és a fibrőnektin-III típűsúismétlődő szakaszők, valamint a nagyfőkú, N-glikőzidős kötésűszénhidráttartalőm. A találmány szerinti hatóanyagőkhőz tartőznak a sejtadhéziós mőlekűlákfragmentűmai és rőkőn mőlekűlái, azők származékai és űtánzói, amelyekmódősítják az axőnnövekedést a közpőnti idegrendszerben. A találmánytárgyáhőz tartőznak az idegsejtek regenerációját serkentő és főkőzó invivő eljárásők és az azőknak megfelelő genetikai kőnstrűkciók - ígyplazmidők, vektőrők és transzgén őrganizműsők - és azőngyógyszerkészítmények, amelyek az ilyen eljárásők megvalósításárahasználhatók. A találmány szerinti hatóanyagők elkészíthetők vektőrőkvagy plazmidők főrmájában és bejűttathatók az idegsejtekbe a közpőntiidegrendszer azőn területein, ahől a regeneráció szükséges, példáűlgénterápiás technikákkal, hőgy egy találmány szerinti hatóanyag őttkifejeződjön és ezáltal serkentse az idegsejtek kívánt növekedését.Mivel a hatóanyagők hőmőfil kötődést műtatnak, alkalmazásűk azidegsejtek növekedésének gátlására is irányűlhat, abban az esetben,amikőr nem kívánt vagy szabályőzatlan növekedés lép fel azidegrendszer területén. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42499595A | 1995-04-19 | 1995-04-19 | |
| US48395995A | 1995-06-07 | 1995-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900060A2 true HUP9900060A2 (hu) | 1999-04-28 |
| HUP9900060A3 HUP9900060A3 (en) | 2001-08-28 |
Family
ID=27026535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900060A HUP9900060A3 (en) | 1995-04-19 | 1996-04-19 | Cns neurite outgrowth modulators, and compositions, cells and methods embodying and using same |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0821591A1 (hu) |
| JP (1) | JPH11504211A (hu) |
| KR (1) | KR19990007893A (hu) |
| AU (1) | AU718508B2 (hu) |
| CA (1) | CA2218599A1 (hu) |
| CZ (1) | CZ330197A3 (hu) |
| EA (1) | EA199700323A1 (hu) |
| HU (1) | HUP9900060A3 (hu) |
| IS (1) | IS4590A (hu) |
| MX (1) | MX9708127A (hu) |
| NO (1) | NO974811L (hu) |
| PL (1) | PL322947A1 (hu) |
| SK (1) | SK142497A3 (hu) |
| TR (2) | TR199801650T2 (hu) |
| WO (1) | WO1996032959A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2190418A1 (en) * | 1996-11-15 | 1998-05-15 | Zhi-Cheng Xiao | Neuron and neural tumor growth regulatory system, antibodies thereto and uses thereof |
| JPH11507845A (ja) * | 1997-02-13 | 1999-07-13 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 神経細胞付着分子スプライシング変種 |
| AU761451B2 (en) * | 1998-09-29 | 2003-06-05 | Vladimir Berezin | NCAM binding compounds |
| AUPQ614200A0 (en) * | 2000-03-10 | 2000-03-30 | Department Of Human Physiology, Flinders University School Of Medicine | Method for treating chronic spinal cord injury |
| JP2004505609A (ja) * | 2000-04-03 | 2004-02-26 | オックスフォード グリコサイエンシズ（ユーケー） リミテッド | 核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用 |
| EP1408333A3 (en) * | 2001-10-03 | 2006-10-25 | Pfizer Products Inc. | Diagnosis and treatment of Alzheimer's disease |
| AR040778A1 (es) | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| US20040081653A1 (en) | 2002-08-16 | 2004-04-29 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer |
| GB0306309D0 (en) | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
| WO2011017605A2 (en) * | 2009-08-07 | 2011-02-10 | Affinimark Technologies, Inc. | Device and methods for the immunological identification of cerebrospinal fluid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100196540B1 (ko) * | 1988-11-04 | 1999-06-15 | 마틴 이. 샤브 | 축색성장 조절인자 |
| WO1993000427A2 (en) * | 1991-06-24 | 1993-01-07 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
| WO1995013291A1 (en) * | 1993-11-08 | 1995-05-18 | New York University | Neuron-glia cell adhesion molecule, ng-cam, in treatment of nerve damage |
-
1996
- 1996-04-19 CA CA002218599A patent/CA2218599A1/en not_active Abandoned
- 1996-04-19 AU AU55572/96A patent/AU718508B2/en not_active Ceased
- 1996-04-19 PL PL96322947A patent/PL322947A1/xx unknown
- 1996-04-19 EP EP96912910A patent/EP0821591A1/en not_active Withdrawn
- 1996-04-19 JP JP8531932A patent/JPH11504211A/ja active Pending
- 1996-04-19 TR TR1998/01650T patent/TR199801650T2/xx unknown
- 1996-04-19 WO PCT/US1996/005434 patent/WO1996032959A1/en not_active Application Discontinuation
- 1996-04-19 TR TR97/01203T patent/TR199701203T1/xx unknown
- 1996-04-19 KR KR1019970707416A patent/KR19990007893A/ko not_active Application Discontinuation
- 1996-04-19 EA EA199700323A patent/EA199700323A1/ru unknown
- 1996-04-19 HU HU9900060A patent/HUP9900060A3/hu unknown
- 1996-04-19 SK SK1424-97A patent/SK142497A3/sk unknown
- 1996-04-19 CZ CZ973301A patent/CZ330197A3/cs unknown
-
1997
- 1997-10-15 IS IS4590A patent/IS4590A/is unknown
- 1997-10-17 NO NO974811A patent/NO974811L/no not_active Application Discontinuation
- 1997-10-20 MX MX9708127A patent/MX9708127A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL322947A1 (en) | 1998-03-02 |
| TR199801650T2 (en) | 1999-03-22 |
| CA2218599A1 (en) | 1996-10-24 |
| AU5557296A (en) | 1996-11-07 |
| EP0821591A1 (en) | 1998-02-04 |
| TR199701203T1 (en) | 1998-03-21 |
| IS4590A (is) | 1997-10-15 |
| AU718508B2 (en) | 2000-04-13 |
| NO974811L (no) | 1997-12-19 |
| CZ330197A3 (cs) | 1998-04-15 |
| MX9708127A (es) | 1998-06-28 |
| KR19990007893A (ko) | 1999-01-25 |
| SK142497A3 (en) | 1999-08-06 |
| WO1996032959A1 (en) | 1996-10-24 |
| NO974811D0 (no) | 1997-10-17 |
| EA199700323A1 (ru) | 1998-04-30 |
| HUP9900060A3 (en) | 2001-08-28 |
| JPH11504211A (ja) | 1999-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69839326T2 (de) | ZUSAMMENSETZUNGEN UND METHODEN ZUR MODULIERUNG DER ZELLULÄREN AKTIVITÄT VON NF-kappaB | |
| ATE230607T1 (de) | Verwendung von neurturin protein zur vorbeugung und behandlung von gehörverlust | |
| HUP9900060A2 (hu) | Központi idegrendszeri axonnövekedés-modulátorok, ezeket tartalmazó készítmények, sejtek és eljárás az előállításukra, valamint felhasználásuk | |
| ATE256475T1 (de) | Verwendung von follistatin zur herstellung eines arzneimittels zur behandlung von muskuläre krankheiten | |
| IL121790A0 (en) | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor (GDNF) protein product | |
| WO1996023065A3 (en) | Inhibition of neovascularization using vegf-specific oligonucleotides | |
| EP1340765A3 (en) | Inverted chimeric and hybrid oligonucleotides | |
| ATE280833T1 (de) | Kationische lipide/dns komplexe zum zielen von genen | |
| EP1048308A3 (en) | Infusion systems for creating microenvironments in a living body | |
| EP1432452A2 (de) | Inhibition von stat-1 | |
| CN102471769A (zh) | 用于具有美容功能的细胞的遗传修饰以提高美容外观的方法和组合物 | |
| CA2056357A1 (en) | Process for the preparation of a ligand-receptor complex | |
| ATE288734T1 (de) | Yack auf wasserbasis für die behandlung von keratinmaterialien, der in einem aerosol-behälter verpackt ist, der mindestens ein gepfropftes siliconpolymer enthält, und dessen verwendungen | |
| WO2002007749A3 (en) | Device providing regulated growth factor delivery for the regeneration of peripheral nerves | |
| WO2002029044A2 (de) | Modulation der transkription pro-inflammatorischer genprodukte | |
| KR20070084456A (ko) | 피불린-5의 생성을 촉진 및/또는 활성을 항진시키기 위한조성물 및 방법 | |
| GEP20033056B (en) | Human BMP-7 Promoter and Method for Exploring Bone-Related Substance by Using the Same | |
| BG101138A (en) | The use of glyceryltriacetate for the treatment of onychomycosis | |
| WO2001031008A3 (en) | Human and rat fgf-20 genes and gene expression products | |
| DE69736076T2 (de) | Enzyme mit s-adenosyl-l-homocystein-hydrolase-ähnlicher aktivität. | |
| WO1995034669A3 (en) | Retroviral gene therapy vectors and therapeutic methods based thereon | |
| DE68908138T2 (de) | Polypeptide mit Zellausdehnungs-Aktivität. | |
| AU7241296A (en) | Modified protein kinase a-specific oligonucleotides and methods of their use | |
| Silva | Small neuroscience: the nanostructure of the central nervous system and emerging nanotechnology applications | |
| WO1996006938A1 (de) | Gentherapeutische behandlung von gefässerkrankungen durch einen zellspezifischen, zellzyklusabhängigen wirkstoff |