MX9708127A - Moduladores del crecimiento de neuritas del sistema nervioso central, y composiciones, celulas y metodos que incluyen y utilizan los mismos. - Google Patents

Moduladores del crecimiento de neuritas del sistema nervioso central, y composiciones, celulas y metodos que incluyen y utilizan los mismos.

Info

Publication number
MX9708127A
MX9708127A MX9708127A MX9708127A MX9708127A MX 9708127 A MX9708127 A MX 9708127A MX 9708127 A MX9708127 A MX 9708127A MX 9708127 A MX9708127 A MX 9708127A MX 9708127 A MX9708127 A MX 9708127A
Authority
MX
Mexico
Prior art keywords
neural
cells
adhesion molecule
methods
neurite outgrowth
Prior art date
Application number
MX9708127A
Other languages
English (en)
Inventor
Melitta Schachner
Original Assignee
Acorda Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics filed Critical Acorda Therapeutics
Publication of MX9708127A publication Critical patent/MX9708127A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)

Abstract

La invencion describe el uso, para promover crecimiento neural in vivo en el sistema nervioso central de un mamífero, de una molécula de adhesion de célula neural que puede superar señales moleculares inhibidoras encontradas sobre células gliales y mielina, para preparar composiciones para promover el crecimiento neural; también describe fragmentos, cognados, cogéneres, imitadores, análogos, células secretoras y moléculas solubles activas de la misma, así como anticuerpos para la misma, y moléculas de ADN, vectores y células transformadas capaces de expresarla; la invencion incluye también líneas de raton transgénico que expresan una molécula de adhesion neural en astrocitos diferenciados, y células y tejidos derivados de los mismos; la expresion de la molécula de adhesion neural mejora el crecimiento de neurita sobre tejido de sistema nervioso central derivado de estos ratones transgénicos; la invencion también describe el uso de las mismas para mejorar el crecimiento neuronal de neuronas de SNC, para mejorar la memoria y para aumentar la eficacia sináptica; también se describen métodos para probar fármacos que modulan los efectos de la molécula de adhesion neural, y sistemas de prueba adecuados para estos métodos.
MX9708127A 1995-04-19 1997-10-20 Moduladores del crecimiento de neuritas del sistema nervioso central, y composiciones, celulas y metodos que incluyen y utilizan los mismos. MX9708127A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42499595A 1995-04-19 1995-04-19
US48395995A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
MX9708127A true MX9708127A (es) 1998-06-28

Family

ID=27026535

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708127A MX9708127A (es) 1995-04-19 1997-10-20 Moduladores del crecimiento de neuritas del sistema nervioso central, y composiciones, celulas y metodos que incluyen y utilizan los mismos.

Country Status (15)

Country Link
EP (1) EP0821591A1 (es)
JP (1) JPH11504211A (es)
KR (1) KR19990007893A (es)
AU (1) AU718508B2 (es)
CA (1) CA2218599A1 (es)
CZ (1) CZ330197A3 (es)
EA (1) EA199700323A1 (es)
HU (1) HUP9900060A3 (es)
IS (1) IS4590A (es)
MX (1) MX9708127A (es)
NO (1) NO974811L (es)
PL (1) PL322947A1 (es)
SK (1) SK142497A3 (es)
TR (2) TR199701203T1 (es)
WO (1) WO1996032959A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190418A1 (en) * 1996-11-15 1998-05-15 Zhi-Cheng Xiao Neuron and neural tumor growth regulatory system, antibodies thereto and uses thereof
CA2243984A1 (en) * 1997-02-13 1998-08-20 Smithkline Beecham P.L.C. Neural cell adhesion molecule splicing variants
CA2343975A1 (en) * 1998-09-29 2000-04-06 Lars Christian Ronn Ncam binding compounds
AUPQ614200A0 (en) * 2000-03-10 2000-03-30 Department Of Human Physiology, Flinders University School Of Medicine Method for treating chronic spinal cord injury
US20020164668A1 (en) * 2000-04-03 2002-11-07 Durham L. Kathryn Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
AU2002330215A1 (en) * 2001-10-03 2003-04-14 Oxford Glycosciences (Uk) Ltd. Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
TWI323265B (en) 2002-08-06 2010-04-11 Glaxo Group Ltd Antibodies
AU2003243151A1 (en) 2002-08-16 2004-03-03 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
GB0306309D0 (en) 2003-03-19 2003-04-23 Glaxo Group Ltd Method of treatment
EP2462444B1 (en) 2009-08-07 2018-10-03 Affinimark Technologies, Inc. Methods for the immunological identification of cerebrospinal fluid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396719B1 (en) * 1988-11-04 1995-07-05 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
WO1993000427A2 (en) * 1991-06-24 1993-01-07 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
WO1995013291A1 (en) * 1993-11-08 1995-05-18 New York University Neuron-glia cell adhesion molecule, ng-cam, in treatment of nerve damage

Also Published As

Publication number Publication date
HUP9900060A2 (hu) 1999-04-28
NO974811D0 (no) 1997-10-17
EP0821591A1 (en) 1998-02-04
HUP9900060A3 (en) 2001-08-28
NO974811L (no) 1997-12-19
TR199801650T2 (en) 1999-03-22
TR199701203T1 (en) 1998-03-21
AU5557296A (en) 1996-11-07
JPH11504211A (ja) 1999-04-20
SK142497A3 (en) 1999-08-06
IS4590A (is) 1997-10-15
PL322947A1 (en) 1998-03-02
KR19990007893A (ko) 1999-01-25
WO1996032959A1 (en) 1996-10-24
CZ330197A3 (cs) 1998-04-15
EA199700323A1 (ru) 1998-04-30
AU718508B2 (en) 2000-04-13
CA2218599A1 (en) 1996-10-24

Similar Documents

Publication Publication Date Title
Hammond Cellular and molecular neurophysiology
Fournier et al. Repulsive factors and axon regeneration in the CNS
Grimpe et al. The extracellular matrix in axon regeneration
Fawcett et al. Defeating inhibition of regeneration by scar and myelin components
PT852585E (pt) Metodo de tratamento da doenca de alzheimer utilizando um produto proteico de factor neurotrofico derivado de uma linha de celulas gliais.
MX9708127A (es) Moduladores del crecimiento de neuritas del sistema nervioso central, y composiciones, celulas y metodos que incluyen y utilizan los mismos.
Grimmelikhuijzen et al. Coelenterate neuropeptides: structure, action and biosynthesis
Edström et al. Axonal outgrowth and neuronal apoptosis in cultured adult mouse dorsal root ganglion preparations: effects of neurotrophins, of inhibition of neurotrophin actions and of prior axotomy
PL334530A1 (en) Novel genes specific in respect to n-axecetyl-l-phosphotricin, used to code amino acids deacetylase, their isolation and application
Willard et al. Molecular events in axonal regeneration
Shin et al. Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration
Edwards et al. Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits
Ferreira et al. Neural regeneration: lessons from regenerating and non-regenerating systems
Kletsas et al. Mechanical stress induces DNA synthesis in PDL fibroblasts by a mechanism unrelated to autocrine growth factor action
Almenar-Queralt et al. Linkers, packages and pathways: new concepts in axonal transport
AU7241296A (en) Modified protein kinase a-specific oligonucleotides and methods of their use
WO2000005373A9 (en) Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity
Guiraudie‐Capraz et al. Increase in polysialyltransferase gene expression following LTP in adult rat dentate gyrus
Bisby Retrograde transport and regeneration studies
Grafstein et al. Role of fast axonal transport in regeneration of goldfish optic axons
Ichikawa et al. The difference of osteocalcin-immunoreactive neurons in the rat dorsal root and trigeminal ganglia: co-expression with nociceptive transducers and central projection
Gobrecht et al. The role of microtubule detyrosination in axon regeneration
WO1998011131A3 (en) Nucleic acid encoding human neuronal calcium channel subunits
ATE260339T1 (de) Antikörper gegen menschliches restrictin
Alexandrescu Growth Factor-Induced Plasticity in Development and Learning: Presynaptic and Postsynaptic Signaling