HUP9802821A2 - Növekedési hormon termelést, illetve kibocsátást elősegítő vegyületek - Google Patents

Növekedési hormon termelést, illetve kibocsátást elősegítő vegyületek

Info

Publication number
HUP9802821A2
HUP9802821A2 HU9802821A HUP9802821A HUP9802821A2 HU P9802821 A2 HUP9802821 A2 HU P9802821A2 HU 9802821 A HU9802821 A HU 9802821A HU P9802821 A HUP9802821 A HU P9802821A HU P9802821 A2 HUP9802821 A2 HU P9802821A2
Authority
HU
Hungary
Prior art keywords
pipe powder
general formula
pipe
powder
piperidine
Prior art date
Application number
HU9802821A
Other languages
English (en)
Inventor
Birgit Sehested Hansen
Thomas Kruse Hansen
Nils Langeland Johansen
Jesper Lau
Behrend Friedrich Lundt
Kjeld Madsen
Bernd Peschke
Henning Thoegersen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP9802821A2 publication Critical patent/HUP9802821A2/hu
Publication of HUP9802821A3 publication Critical patent/HUP9802821A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyületek, ahől azáltalánős képletben P jelentése 0 vagy 1, A jelentése hidrőgénatőm vagy R1-(CH2)q-(X)r-(CH2)s-CO-csőpőrt, ahől R1 jelentése hidrőgénatőm, imidazőlil, gűanidinő-, piperazinő-,mőrfőlinő-, piperidinőcsőpőrt vagy N(R2)-csőpőrt, X jelentése, amennyiben r jelentése 1, -NH-, -CH2-, -CH=CH-csőpőrt, -C(R16)R17)- általánős képletű csőpőrt, vagy ciklőhexil, fenil-,naftil- vagy tienilcsőpőrt, B jelentése (G)t-(H)ű általánős képletű csőpőrt, ahől G és H jelentése aminősav-maradék csőpőrt, és ahől a G és H közöttiamidkötés kívánt esetben Y-NR18- általánős képletű csőpőrttalhelyettesíthető; C jelentése -NH-CH[(CH2)w-R4]-CO- általánős képletű D-aminősav-csőpőrt,ahől R4 jelentése többek között adőtt esetben szűbsztitűált fenil-,naftil-, tienil-, piridil- vagy indőlilcsőpőrt. D jelentése -NR20-CH[(CH2)k-R5]-CO- általánős képletű D-aminősav-csőpőrt, vagy D jelentése -NR20-CH[(CH2)l-R5]-CH2-R6 általánős képletű csőpőrt vagy -NR20-CH[(CH2)m-R5]-CO-R6 általánős képletű csőpőrt, ahől R20 jelentésealkil-, aralkilcsőpőrt, R5 jelentése megegyezik R4 jelentésével, R6jelentése piperazinő-, mőrfőlinő-, piperidinő-, hidrőxilcsőpőrt vagy -N(R7)-R8 általánős képletű csőpőrt, E jelentése amennyiben p jelentése 1, -NH-CH(R10)-(CH2)v-R9 általánősképletű csőpőrt, ahől R9 jelentése többek között hidrőgénatőm,imidazőlil-, gűanidinő-, piperazinő-, mőrfőlinő-, piperidinőcsőpőrt, R10 jelentése hidrőgénatőm, karbőxilcsőpőrt, -CH2-R13 vagy -CO-R13általánős képletű csőpőrt vagy -CH2-OH csőpőrt. A találmány szerinti vegyületek alkalmasak a hypőphysis növekedésihőrmőn kibőcsátásának stiműlálására és gyógyszerészetben vagy állatitermelésben alkalmazhatók. ŕ
HU9802821A 1995-06-22 1996-06-19 Compounds with growth hormone releasing properties HUP9802821A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK71995 1995-06-22
DK137195 1995-12-04

Publications (2)

Publication Number Publication Date
HUP9802821A2 true HUP9802821A2 (hu) 1999-03-29
HUP9802821A3 HUP9802821A3 (en) 2000-03-28

Family

ID=26064522

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802821A HUP9802821A3 (en) 1995-06-22 1996-06-19 Compounds with growth hormone releasing properties

Country Status (12)

Country Link
EP (1) EP0833845A1 (hu)
KR (1) KR19990028303A (hu)
AU (1) AU711104B2 (hu)
BR (1) BR9608909A (hu)
CA (1) CA2224434A1 (hu)
CZ (1) CZ287948B6 (hu)
HU (1) HUP9802821A3 (hu)
IL (1) IL122371A0 (hu)
NO (1) NO975992L (hu)
PL (1) PL186520B1 (hu)
TW (1) TW458958B (hu)
WO (1) WO1997000894A1 (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3938797A (en) * 1996-08-29 1998-03-19 Novo Nordisk A/S Transdermal delivery of peptides
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU7906998A (en) 1997-06-20 1999-01-04 Novo Nordisk A/S Compounds with growth hormone releasing properties
CN1213036C (zh) 1997-08-22 2005-08-03 科研制药株式会社 新的酰胺类衍生物
ATE281467T1 (de) 1998-01-16 2004-11-15 Novo Nordisk As Verbindungen mit wachstumshormon-freisetzenden eigenschaften
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
EE200000660A (et) * 1998-05-12 2002-04-15 Warner-Lambert Company Valk farnesüültransferaasi ja HMG CoA reduktaasi inhibiitorite kombinatsioonid ja nende kasutamine vähi raviks
RU2298547C2 (ru) * 1998-06-30 2007-05-10 Ново Нордиск А/С Соединения и фармацевтическая композиция, обладающие свойствами высвобождения гормона роста, способ стимуляции выделения гормона роста из гипофиза млекопитающего
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU5671099A (en) 1998-08-14 2000-03-06 The Administrators Of The Tulane Eductional Fund Compounds having growth hormone releasing activity
KR100699404B1 (ko) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
EP1159964B1 (en) 2000-05-31 2009-10-28 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating gastrointestinal motility
EP1343751A2 (en) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
CA2432908A1 (en) 2000-12-20 2002-06-27 Bristol-Myers Squibb Pharma Company Diamines as modulators of chemokine receptor activity
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
AU2008241532A1 (en) 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
EP3023426A1 (en) 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663146A (en) * 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
US5767085A (en) * 1993-12-23 1998-06-16 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
NO975992L (no) 1998-02-20
PL186520B1 (pl) 2004-01-30
EP0833845A1 (en) 1998-04-08
IL122371A0 (en) 1998-06-15
PL324200A1 (en) 1998-05-11
HUP9802821A3 (en) 2000-03-28
BR9608909A (pt) 1999-03-02
KR19990028303A (ko) 1999-04-15
CZ408197A3 (cs) 1998-05-13
CZ287948B6 (cs) 2001-03-14
TW458958B (en) 2001-10-11
JPH11507928A (ja) 1999-07-13
AU6188296A (en) 1997-01-22
JP4173541B2 (ja) 2008-10-29
MX9710377A (es) 1998-03-29
WO1997000894A1 (en) 1997-01-09
CA2224434A1 (en) 1997-01-09
AU711104B2 (en) 1999-10-07
NO975992D0 (no) 1997-12-19

Similar Documents

Publication Publication Date Title
HUP9802821A2 (hu) Növekedési hormon termelést, illetve kibocsátást elősegítő vegyületek
FI941987A0 (fi) Uudet aminohappojohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset
HUP0302962A2 (hu) Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
SE9604341D0 (sv) Hepta-peptide oxytocin analogue
NZ331319A (en) Cyclic amine derivatives that are CCR-3 receptor (chemokine receptor) antagonists, compositions containing them and methods for their use (to combat eosinophil induced diseases).
HUP9901209A2 (hu) Opioid analóg peptid vegyületek, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
TR200003848T2 (tr) VLA-4'e bağlı hücre bağlanmasının peptidil olmayan önleyicileri.
CA2115355A1 (en) Novel tetrapeptide derivative
HUP0004259A2 (hu) VLA-4 által mediált leukocita adhéziót gátló szubsztituált fenilalanin-származékok, ezeket tartalmazó gyógyászati készítmények
KR900014424A (ko) 아미노산 유도체
NO934423D0 (no) Preparater for vedvarende frigiving
CA2060034A1 (en) Tumour growth-inhibiting somatostatin analogues, pharmaceutical compositions containing them and process for preparing same
NZ333591A (en) Thiazole compounds, process of manufacture and their use for treating prophylaxis and other diseases
DE69104034T2 (de) N-phenylglycinderivate, ihre herstellung und medikamente, die sie enthalten.
CA2213080A1 (en) 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
KR880007563A (ko) 신규의 레닌-억제올리고펩티드, 그의 제법 및 그의 용도
HUP9902668A2 (hu) Piperazinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
GB1374414A (en) 1-acyl-3-amino-alkyl-indoles and their preparation
KR900701828A (ko) 펩티드 화합물
KR900004739A (ko) 피페콜산-함유 펩톨라이드, 그의 제법 및 그를 함유하는 약학 조성물
DE69132707T2 (de) N-Acyldipeptide, und pharmazeutische Präparate davon
FR2658821B1 (fr) Nouvelles propanamines, leurs proprietes pharmacologiques et leur application a des fins therapeutiques, notamment antidiarrheuiques.
FI931474A0 (fi) Peptider med modifikationer i n-terminalen
KR880007491A (ko) Paf-길항물질인피페라진화합물
GB1292094A (en) A phenylglycine derivative