PL324200A1 - Compunds exhibiting growth hormone liberating properties - Google Patents

Compunds exhibiting growth hormone liberating properties

Info

Publication number
PL324200A1
PL324200A1 PL96324200A PL32420096A PL324200A1 PL 324200 A1 PL324200 A1 PL 324200A1 PL 96324200 A PL96324200 A PL 96324200A PL 32420096 A PL32420096 A PL 32420096A PL 324200 A1 PL324200 A1 PL 324200A1
Authority
PL
Poland
Prior art keywords
compunds
liberating
properties
growth hormone
exhibiting growth
Prior art date
Application number
PL96324200A
Other versions
PL186520B1 (en
Inventor
Nils Langeland Johansen
Jesper Lau
Kjeld Madsen
Henning Thoegersen
Behrend Friedrich Lundt
Bernd Peschke
Thomas Kruse Hansen
Birgit Sehested Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PL324200A1 publication Critical patent/PL324200A1/en
Publication of PL186520B1 publication Critical patent/PL186520B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL96324200A 1995-06-22 1996-06-19 Compunds exhibiting growth hormone liberating properties PL186520B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK71995 1995-06-22
DK137195 1995-12-04
PCT/DK1996/000266 WO1997000894A1 (en) 1995-06-22 1996-06-19 Compounds with growth hormone releasing properties

Publications (2)

Publication Number Publication Date
PL324200A1 true PL324200A1 (en) 1998-05-11
PL186520B1 PL186520B1 (en) 2004-01-30

Family

ID=26064522

Family Applications (1)

Application Number Title Priority Date Filing Date
PL96324200A PL186520B1 (en) 1995-06-22 1996-06-19 Compunds exhibiting growth hormone liberating properties

Country Status (12)

Country Link
EP (1) EP0833845A1 (en)
KR (1) KR19990028303A (en)
AU (1) AU711104B2 (en)
BR (1) BR9608909A (en)
CA (1) CA2224434A1 (en)
CZ (1) CZ287948B6 (en)
HU (1) HUP9802821A3 (en)
IL (1) IL122371A0 (en)
NO (1) NO975992L (en)
PL (1) PL186520B1 (en)
TW (1) TW458958B (en)
WO (1) WO1997000894A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008492A1 (en) * 1996-08-29 1998-03-05 Novo Nordisk A/S Transdermal delivery of peptides
JP4116097B2 (en) 1997-06-20 2008-07-09 ノボ ノルディスク アクティーゼルスカブ Compounds with growth hormone releasing properties
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
CA2301566A1 (en) 1997-08-22 1999-03-04 Kaken Pharmaceutical Co., Ltd. N-acylated lipophilic amino acid derivatives
EP1047709B1 (en) 1998-01-16 2004-11-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
EA003860B1 (en) * 1998-05-12 2003-10-30 Варнер-Ламберт Компани Combinations of protein farnesyltransferase and hmg coa reductase inhibitors and their use to treat cancer
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU771644B2 (en) * 1998-06-30 2004-04-01 Helsinn Healthcare Sa Compounds with growth hormone releasing properties
WO2000009537A2 (en) 1998-08-14 2000-02-24 Administrators Of The Tulane Educational Fund Compounds having growth hormone releasing activity
WO2000048623A1 (en) 1999-02-18 2000-08-24 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
DE60140285D1 (en) 2000-05-31 2009-12-10 Pfizer Prod Inc Use of growth hormone secretagogues to promote the mobility of the digestive tract
EP1343751A2 (en) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
HUP0303540A2 (en) 2000-12-20 2004-01-28 Bristol-Myers Squibb Pharma Co. Diamines as modulators of chemokine receptor activity, pharmaceutical compositions containing them and their use
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
EA200901077A1 (en) 2007-02-09 2010-04-30 Транзим Фарма, Инк. MACRO CYCLIC MODULATORS OF THE GREEL RECEPTOR AND THEIR APPLICATION
WO2009079797A1 (en) 2007-12-26 2009-07-02 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
WO2010006438A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663146A (en) * 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
SK281963B6 (en) * 1993-12-23 2001-09-11 Novo Nordisk A/S Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
KR19990028303A (en) 1999-04-15
PL186520B1 (en) 2004-01-30
IL122371A0 (en) 1998-06-15
JPH11507928A (en) 1999-07-13
JP4173541B2 (en) 2008-10-29
BR9608909A (en) 1999-03-02
AU6188296A (en) 1997-01-22
NO975992L (en) 1998-02-20
AU711104B2 (en) 1999-10-07
TW458958B (en) 2001-10-11
MX9710377A (en) 1998-03-29
CA2224434A1 (en) 1997-01-09
HUP9802821A3 (en) 2000-03-28
NO975992D0 (en) 1997-12-19
HUP9802821A2 (en) 1999-03-29
CZ287948B6 (en) 2001-03-14
CZ408197A3 (en) 1998-05-13
EP0833845A1 (en) 1998-04-08
WO1997000894A1 (en) 1997-01-09

Similar Documents

Publication Publication Date Title
PL324200A1 (en) Compunds exhibiting growth hormone liberating properties
HUP9802580A3 (en) Compounds with growth hormone releasing properties
AU6772996A (en) 2-acylaminopropanamides as growth hormone secretagogues
EP0858351A4 (en) Anti-coring needle
HUP9900301A3 (en) Hormone patch
EP0871705A4 (en) Human ccn-like growth factor
EP0741578A4 (en) Human growth hormone
AU6724496A (en) 2-acylaminopropanamines as growth hormone secretagogues
AU1048797A (en) Float garment
ZA961007B (en) Compounds with growth hormone releasing properties
EP0833904A4 (en) Fibroblast growth factor-14
ZA961008B (en) Compounds with growth hormone releasing properties
AU4453396A (en) Growth factor analogs
PL325170A1 (en) Bipolar forms of throwaflocacin
EP0796095A4 (en) Methods of inhibiting growth hormone effects
GB2307644B (en) Resectoscope
GB9424232D0 (en) Growth factor expression
GB9516247D0 (en) Socks
EP0891372A4 (en) Growth factor htter36
ZA965279B (en) Compounds with growth hormone releasing properties
ZA9610775B (en) Compounds with growth hormone releasing properties
ZA96544B (en) Compounds with growth hormone releasing properties
AU124629S (en) Small flower pot
ZA967973B (en) Human growth hormone variants
AU125290S (en) Sinker