HUP9802546A2 - 1-[2-(2,3-Dihidro-1H-indén-1-il)-etil]-4-(naftalen-1-il)-piperazin-származékok, eljárás előállításukra és gyógyászati alkalmazásuk - Google Patents

1-[2-(2,3-Dihidro-1H-indén-1-il)-etil]-4-(naftalen-1-il)-piperazin-származékok, eljárás előállításukra és gyógyászati alkalmazásuk

Info

Publication number
HUP9802546A2
HUP9802546A2 HU9802546A HUP9802546A HUP9802546A2 HU P9802546 A2 HUP9802546 A2 HU P9802546A2 HU 9802546 A HU9802546 A HU 9802546A HU P9802546 A HUP9802546 A HU P9802546A HU P9802546 A2 HUP9802546 A2 HU P9802546A2
Authority
HU
Hungary
Prior art keywords
compounds
inden
naphthalen
dihydro
ethyl
Prior art date
Application number
HU9802546A
Other languages
English (en)
Inventor
Pascal George
Jean Francois Gibert
David Machnik
Philippe Manoury
Michel Peynot
Mireille Sevrin
Arlette Tixidre
DaniŐle de Peretti
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of HUP9802546A2 publication Critical patent/HUP9802546A2/hu
Publication of HUP9802546A3 publication Critical patent/HUP9802546A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

A találmány tárgya új, (I) általánős képletű vegyületek, ahől X jelentése hidrőgénatőm, hidrőxil-, 1-3 szénatőmős alkőxi- vagyciklőprőpil-metőxi-csőpőrt, és Y jelentése hidrőgénatőm, hidrőxil- vagy metőxicsőpőrt, szabad bázis vagy addíciós só állapőtban, tiszta enantiőmer vagyenantiőmer keverék főrmában. A találmány a vegyületek előállítására szőlgáló eljárásra és avegyületeket tartalmaz gyógyszerkészítményekre is kiterjed. A találmány szerinti vegyületek erős affinitással rendelkeznek az5HT1A, 5HT1D és 5Ht1C típűsú szerőtőninerg receptőrőkkal szemben ésközepes affinitással rendelkeznek az 5HT2 receptőrőkkal szemben. ŕ
HU9802546A 1995-08-09 1996-08-01 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4-(naphthalen-1-yl)piperazine derivatives, preparation thereof and therapeutical use thereof HUP9802546A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9509684A FR2737724B1 (fr) 1995-08-09 1995-08-09 Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
HUP9802546A2 true HUP9802546A2 (hu) 1999-02-01
HUP9802546A3 HUP9802546A3 (en) 1999-10-28

Family

ID=9481836

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802546A HUP9802546A3 (en) 1995-08-09 1996-08-01 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4-(naphthalen-1-yl)piperazine derivatives, preparation thereof and therapeutical use thereof

Country Status (20)

Country Link
US (1) US5929078A (hu)
EP (1) EP0843670A1 (hu)
JP (1) JP2000501699A (hu)
KR (1) KR19990035954A (hu)
CN (1) CN1199398A (hu)
AR (1) AR003222A1 (hu)
AU (1) AU707372B2 (hu)
BR (1) BR9609977A (hu)
CA (1) CA2228843A1 (hu)
CO (1) CO4750833A1 (hu)
CZ (1) CZ36898A3 (hu)
FR (1) FR2737724B1 (hu)
HU (1) HUP9802546A3 (hu)
IL (1) IL123187A0 (hu)
NO (1) NO980529L (hu)
NZ (1) NZ315363A (hu)
PL (1) PL324966A1 (hu)
SK (1) SK16798A3 (hu)
WO (1) WO1997006155A1 (hu)
ZA (1) ZA966772B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE358300A (hu) * 1928-04-28
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
NL132357C (hu) * 1966-09-03
DE2037852C3 (de) * 1970-07-30 1980-06-26 Boehringer Sohn Ingelheim Neue Piperazinderivate und Verfahren zu ihrer Herstellung
CA2176722A1 (en) * 1993-12-28 1995-07-06 Ruth E. Ten Brink Heterocyclic compounds for the treatment of cns and cardiovascular disorders
FR2716193B1 (fr) * 1994-02-16 1996-04-05 Synthelabo Dérivés de 1[2-(1h-inden-3-yl)ethyl]-4-(naphtalen-1-yl)piperazine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
NO980529D0 (no) 1998-02-06
IL123187A0 (en) 1998-09-24
AR003222A1 (es) 1998-07-08
FR2737724A1 (fr) 1997-02-14
CA2228843A1 (en) 1997-02-20
CZ36898A3 (cs) 1998-05-13
WO1997006155A1 (fr) 1997-02-20
AU707372B2 (en) 1999-07-08
AU6705396A (en) 1997-03-05
JP2000501699A (ja) 2000-02-15
ZA966772B (en) 1997-02-19
CN1199398A (zh) 1998-11-18
CO4750833A1 (es) 1999-03-31
SK16798A3 (en) 1998-08-05
FR2737724B1 (fr) 1997-09-05
KR19990035954A (ko) 1999-05-25
BR9609977A (pt) 1999-01-12
NZ315363A (en) 1998-10-28
EP0843670A1 (fr) 1998-05-27
HUP9802546A3 (en) 1999-10-28
NO980529L (no) 1998-04-14
PL324966A1 (en) 1998-06-22
MX9801057A (es) 1998-05-31
US5929078A (en) 1999-07-27

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