ZA966772B - 1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics. - Google Patents

1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics.

Info

Publication number
ZA966772B
ZA966772B ZA9606772A ZA966772A ZA966772B ZA 966772 B ZA966772 B ZA 966772B ZA 9606772 A ZA9606772 A ZA 9606772A ZA 966772 A ZA966772 A ZA 966772A ZA 966772 B ZA966772 B ZA 966772B
Authority
ZA
South Africa
Prior art keywords
naphth
inden
therapeutics
dihydro
ethyl
Prior art date
Application number
ZA9606772A
Other languages
English (en)
Inventor
Pascal George
Philippe Manoury
Daniele De Peretti
Arlette Tixidre
Mireille Sevrin
Michel Peynot
Jean Francois Gibert
David Machnik
Original Assignee
Synthelbo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelbo filed Critical Synthelbo
Publication of ZA966772B publication Critical patent/ZA966772B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
ZA9606772A 1995-08-09 1996-08-08 1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics. ZA966772B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9509684A FR2737724B1 (fr) 1995-08-09 1995-08-09 Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ZA966772B true ZA966772B (en) 1997-02-19

Family

ID=9481836

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9606772A ZA966772B (en) 1995-08-09 1996-08-08 1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics.

Country Status (20)

Country Link
US (1) US5929078A (hu)
EP (1) EP0843670A1 (hu)
JP (1) JP2000501699A (hu)
KR (1) KR19990035954A (hu)
CN (1) CN1199398A (hu)
AR (1) AR003222A1 (hu)
AU (1) AU707372B2 (hu)
BR (1) BR9609977A (hu)
CA (1) CA2228843A1 (hu)
CO (1) CO4750833A1 (hu)
CZ (1) CZ36898A3 (hu)
FR (1) FR2737724B1 (hu)
HU (1) HUP9802546A3 (hu)
IL (1) IL123187A0 (hu)
NO (1) NO980529L (hu)
NZ (1) NZ315363A (hu)
PL (1) PL324966A1 (hu)
SK (1) SK16798A3 (hu)
WO (1) WO1997006155A1 (hu)
ZA (1) ZA966772B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE358300A (hu) * 1928-04-28
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
NL132357C (hu) * 1966-09-03
DE2037852C3 (de) * 1970-07-30 1980-06-26 Boehringer Sohn Ingelheim Neue Piperazinderivate und Verfahren zu ihrer Herstellung
CN1046507C (zh) * 1993-12-28 1999-11-17 法玛西雅厄普约翰美国公司 用于治疗中枢神经系统和心血管疾病的杂环化合物
FR2716193B1 (fr) * 1994-02-16 1996-04-05 Synthelabo Dérivés de 1[2-(1h-inden-3-yl)ethyl]-4-(naphtalen-1-yl)piperazine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
US5929078A (en) 1999-07-27
CN1199398A (zh) 1998-11-18
NO980529D0 (no) 1998-02-06
BR9609977A (pt) 1999-01-12
HUP9802546A2 (hu) 1999-02-01
JP2000501699A (ja) 2000-02-15
CO4750833A1 (es) 1999-03-31
CZ36898A3 (cs) 1998-05-13
WO1997006155A1 (fr) 1997-02-20
FR2737724A1 (fr) 1997-02-14
NO980529L (no) 1998-04-14
SK16798A3 (en) 1998-08-05
CA2228843A1 (en) 1997-02-20
AU6705396A (en) 1997-03-05
PL324966A1 (en) 1998-06-22
EP0843670A1 (fr) 1998-05-27
FR2737724B1 (fr) 1997-09-05
NZ315363A (en) 1998-10-28
MX9801057A (es) 1998-05-31
KR19990035954A (ko) 1999-05-25
AR003222A1 (es) 1998-07-08
IL123187A0 (en) 1998-09-24
AU707372B2 (en) 1999-07-08
HUP9802546A3 (en) 1999-10-28

Similar Documents

Publication Publication Date Title
ZA969090B (en) 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives.
HUP9601328A3 (en) 4-(aryl-amino-methylene)-2,4-dihydro-pyrazol-3-one derivatives and pharmaceutical compositions containing them
NO2005009I1 (no) Emselex-Darifenacin-IUPAC-nabn: (S)-2-(1-Ä2-(2,3-dihydrobenzofuran-5-yl)etylÜ3-pyrrolidinylÜ-2,2-difenylacetamid
TR199600438A2 (tr) Piperazin türevleri.
HRP960503B1 (en) (-) cis-6(s)-phenyl-5(r)/4-(2-pyrrolidin-1-ylethoxy)-5,6,7,8-tetrahydronaphthalen-2-ol d-tartarate
NZ325845A (en) 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives, preparation and pharmaceutical use thereof
AU6524996A (en) Piperazine derivatives and their use as 5-HT1A antagonists
EP0796096A4 (en) 4,4- (DISUBSTITUTED) CYCLOHEXAN-1-CARBOXYLATE MONOMERS AND RELATED COMPOUNDS
GB2297749B (en) 1-[2-(substituted vinyl)]-3-4--dihydro-5h-2,3-benzodiazepine derivatives
ZA918293B (en) 1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application
ZA966772B (en) 1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics.
IL112661A0 (en) 1-[2-(1h-inden-3-yl) ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics
IL136231A (en) Process and intermediate for preparing cis-1-(2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)- phenoxy] ethyl) pyrrolidine
EP0828493A4 (en) 4.4-DISUBSTITUTED CYCLOHEXANE-1-OL MONOMERS AND RELATED COMPOUNDS
FR2722099B1 (fr) Nouveau produit de combinaison comprenant de la carpipramine et un neuroleptique.
CS10790A2 (en) 2-(4-(2-chlorodibenzo/b,f/thiepin-10-yloxy/ethyl-1-piperazinyl)ethanol and its maleate
ATE194334T1 (de) 3-phenyl-1,4-dialkyl-1,2,4-triazolium salze und ihre verwendung als antidepressiva
Sjøholt et al. Quality management system-QMS. Selected articles
GB2297750B (en) 1-[2-(Substituted vinyl)]-5h-2,3-benzodiazepine derivatives
IL116490A0 (en) 4,4-(disubstituted) cyclohexan-1-ol monomers and related compounds
ITFI940047A0 (it) Procedimento per la fabbricazione di supporti cartacei per carta-moneta, carte-valori ed altro, e supporti cosi' realizzati
HUP9701007A3 (en) Process for producing 1-[2-(2,4-difluoro-phenyl)-2,3-epoxi-propyl]-1h-1,2,4-triazol and its salts
HK1019328A1 (en) 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists