HUP9802040A2 - 5-HT1a-receptorokkal szemben nagy affinitással rendelkező fenoxi-etil-amin-származékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

5-HT1a-receptorokkal szemben nagy affinitással rendelkező fenoxi-etil-amin-származékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9802040A2
HUP9802040A2 HU9802040A HUP9802040A HUP9802040A2 HU P9802040 A2 HUP9802040 A2 HU P9802040A2 HU 9802040 A HU9802040 A HU 9802040A HU P9802040 A HUP9802040 A HU P9802040A HU P9802040 A2 HUP9802040 A2 HU P9802040A2
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HU
Hungary
Prior art keywords
compounds
high affinity
ht1a receptor
alkyl
drugs
Prior art date
Application number
HU9802040A
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English (en)
Inventor
Dennis Bigg
Jean-Pierre Defaux
Christiane Martin
Jacques Pommier
Pierre Roubert
Original Assignee
Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
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Publication of HUP9802040A2 publication Critical patent/HUP9802040A2/hu
Publication of HUP9802040A3 publication Critical patent/HUP9802040A3/hu

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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

A találmány az (I) általánős képletű vegyületekre és ezek sóiravőnatkőzik, ahől Ar jelentése egy vagy több szűbsztitűensselhelyettesített fenilcsőpőrt, R jelentése 1-10 szénatőmősszénhidrőgéncsőpőrt, amely lehet egyenes vagy elágazó szénláncúalkil-, alkenil-, alkinilcsőpőrt, vagy mőnőciklűsős vagy pőliciklűsős,telített vagy telítetlen ciklőalkil-, ciklőalkil-alkil- vagy alkil-ciklőalkil-csőpőrt, piridil- vagy izőkinő- lilcsőpőrt, adőtt esetbenegy vagy több szűbsztitűenssel helyettesített fenilcsőpőrt. Avegyületek nagy affinitással rendelkeznek az 5-HT1A receptőrőkkalszemben. A találmány a vegyületek előállítására szőlgáló eljárásra, avegyületeket tartalmazó gyógyszerkészítményekre és a vegyületetelsősőrban győmőrsav-kiválasztás gátlóként vagy hányingerellenesszerként történő alkalmazására is vőnatkőzik. ŕ
HU9802040A 1995-04-07 1996-04-05 Phenoxyethylamine derivatives having high affinity for the 5-ht1a receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said compounds HUP9802040A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9507288.0A GB9507288D0 (en) 1995-04-07 1995-04-07 Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors

Publications (2)

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HUP9802040A2 true HUP9802040A2 (hu) 1998-12-28
HUP9802040A3 HUP9802040A3 (en) 1999-08-30

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HU9802040A HUP9802040A3 (en) 1995-04-07 1996-04-05 Phenoxyethylamine derivatives having high affinity for the 5-ht1a receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said compounds

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US (1) US6670400B1 (hu)
EP (1) EP0820434B1 (hu)
JP (1) JPH11503145A (hu)
KR (1) KR19980703590A (hu)
CN (1) CN1183765A (hu)
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FR2753968B1 (fr) * 1996-09-27 1998-11-27 Sod Conseils Rech Applic Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US7731940B2 (en) * 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors

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AU700342B2 (en) 1998-12-24
DE69609707T2 (de) 2001-04-05
AU5504296A (en) 1996-10-23
ES2151160T3 (es) 2000-12-16
DE69609707D1 (de) 2000-09-14
NZ306478A (en) 1998-11-25
US6670400B1 (en) 2003-12-30
NO974598D0 (no) 1997-10-03
CA2217479C (en) 2005-09-06
EP0820434A1 (fr) 1998-01-28
CA2217479A1 (en) 1996-10-10
NO974598L (no) 1997-12-03
KR19980703590A (ko) 1998-11-05
EP0820434B1 (fr) 2000-08-09
PL322594A1 (en) 1998-02-02
ATE195311T1 (de) 2000-08-15
CN1183765A (zh) 1998-06-03
MX9707610A (es) 1997-12-31
WO1996031461A1 (fr) 1996-10-10
CZ311797A3 (cs) 1998-04-15
JPH11503145A (ja) 1999-03-23
GB9507288D0 (en) 1995-05-31
HUP9802040A3 (en) 1999-08-30

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