HUP9801228A2 - Szubsztituált benzamidinek és az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
Szubsztituált benzamidinek és az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUP9801228A2 HUP9801228A2 HU9801228A HUP9801228A HUP9801228A2 HU P9801228 A2 HUP9801228 A2 HU P9801228A2 HU 9801228 A HU9801228 A HU 9801228A HU P9801228 A HUP9801228 A HU P9801228A HU P9801228 A2 HUP9801228 A2 HU P9801228A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- producing
- substituted phenyl
- medicaments containing
- powder
- Prior art date
Links
- -1 phenyl amidines Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000003937 benzamidines Chemical class 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány tárgyát a vérlemezkék aggregációját gátló hatású (I)általánős képletű benzamidinek és sóik, az ezeket tartalmazógyógyszerkészítmények, tővábbá az alkalmazásűkra és az előállításűkraszőlgáló eljárásők képezik. A találmány szerint az (I) általánősképletű vegyületeket - ahől X és Z adőtt esetben szűbsztitűált alkiléncsőpőrt; Y ciklőalkiléncsőpőrt vagy kétértékű heterőciklűsős, előnyösenpiperidindiil- vagy piperazindiil-csőpőrt; R1, R2, R3 és R4 előnyösen hidrőgénatőm; és R5 előnyösen hidrőgénatőm, alkil- vagy ciklőalkilcsőpőrt. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19515500A DE19515500A1 (de) | 1995-04-27 | 1995-04-27 | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
PCT/EP1996/001615 WO1996033970A1 (de) | 1995-04-27 | 1996-04-18 | Substituierte phenylamidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9801228A2 true HUP9801228A2 (hu) | 1998-08-28 |
HUP9801228A3 HUP9801228A3 (en) | 1998-09-28 |
HU222050B1 HU222050B1 (hu) | 2003-04-28 |
Family
ID=7760507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9801228A HU222050B1 (hu) | 1995-04-27 | 1996-04-18 | Szubsztituált benzamidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
Country Status (24)
Country | Link |
---|---|
US (1) | US5958952A (hu) |
EP (1) | EP0824515B1 (hu) |
JP (1) | JPH11504630A (hu) |
KR (1) | KR19990008011A (hu) |
AT (1) | ATE200277T1 (hu) |
AU (1) | AU703946B2 (hu) |
BG (1) | BG63385B1 (hu) |
BR (1) | BR9608038A (hu) |
CA (1) | CA2219337A1 (hu) |
CZ (1) | CZ288764B6 (hu) |
DE (2) | DE19515500A1 (hu) |
DK (1) | DK0824515T3 (hu) |
EE (1) | EE03919B1 (hu) |
ES (1) | ES2158309T3 (hu) |
GR (1) | GR3036023T3 (hu) |
HU (1) | HU222050B1 (hu) |
NO (1) | NO309422B1 (hu) |
NZ (1) | NZ306451A (hu) |
PL (1) | PL184276B1 (hu) |
PT (1) | PT824515E (hu) |
RU (1) | RU2167857C2 (hu) |
SK (1) | SK282232B6 (hu) |
TR (1) | TR199701258T1 (hu) |
WO (1) | WO1996033970A1 (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2206053A1 (en) * | 1994-12-01 | 1996-06-06 | Toyama Chemical Co., Ltd. | Novel 2,3-diketopiperazine derivatives or their salts |
US5942544A (en) * | 1996-02-22 | 1999-08-24 | Dupont Pharmaceuticals Company | α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors |
DE19833105A1 (de) * | 1998-07-23 | 2000-01-27 | Boehringer Ingelheim Pharma | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US6242466B1 (en) | 1998-07-23 | 2001-06-05 | Boehringer Ingelheim Pharma Kg | Substituted phenylamidines |
DE10002510A1 (de) * | 2000-01-21 | 2001-07-26 | Boehringer Ingelheim Pharma | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE4127404A1 (de) * | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0630366B1 (en) * | 1991-10-15 | 2003-01-02 | G.D. Searle & Co. | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
US5254573A (en) * | 1991-10-15 | 1993-10-19 | Monsanto Company | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
-
1995
- 1995-04-27 DE DE19515500A patent/DE19515500A1/de not_active Withdrawn
-
1996
- 1996-04-18 EP EP96912018A patent/EP0824515B1/de not_active Expired - Lifetime
- 1996-04-18 JP JP8532141A patent/JPH11504630A/ja not_active Ceased
- 1996-04-18 SK SK1443-97A patent/SK282232B6/sk unknown
- 1996-04-18 PT PT96912018T patent/PT824515E/pt unknown
- 1996-04-18 AU AU55008/96A patent/AU703946B2/en not_active Ceased
- 1996-04-18 TR TR97/01258T patent/TR199701258T1/xx unknown
- 1996-04-18 ES ES96912018T patent/ES2158309T3/es not_active Expired - Lifetime
- 1996-04-18 RU RU97119520/04A patent/RU2167857C2/ru active
- 1996-04-18 DE DE59606725T patent/DE59606725D1/de not_active Expired - Fee Related
- 1996-04-18 AT AT96912018T patent/ATE200277T1/de not_active IP Right Cessation
- 1996-04-18 PL PL96322969A patent/PL184276B1/pl unknown
- 1996-04-18 CA CA002219337A patent/CA2219337A1/en not_active Abandoned
- 1996-04-18 BR BR9608038A patent/BR9608038A/pt not_active Application Discontinuation
- 1996-04-18 EE EE9700292A patent/EE03919B1/xx not_active IP Right Cessation
- 1996-04-18 NZ NZ306451A patent/NZ306451A/en unknown
- 1996-04-18 US US08/945,611 patent/US5958952A/en not_active Expired - Lifetime
- 1996-04-18 KR KR1019970707535A patent/KR19990008011A/ko not_active Application Discontinuation
- 1996-04-18 WO PCT/EP1996/001615 patent/WO1996033970A1/de not_active Application Discontinuation
- 1996-04-18 DK DK96912018T patent/DK0824515T3/da active
- 1996-04-18 CZ CZ19973406A patent/CZ288764B6/cs not_active IP Right Cessation
- 1996-04-18 HU HU9801228A patent/HU222050B1/hu not_active IP Right Cessation
-
1997
- 1997-10-20 BG BG101983A patent/BG63385B1/bg unknown
- 1997-10-24 NO NO974945A patent/NO309422B1/no not_active IP Right Cessation
-
2001
- 2001-06-13 GR GR20010400876T patent/GR3036023T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HFG4 | Patent granted, date of granting |
Effective date: 20030122 |
|
HMM4 | Cancellation of final prot. due to non-payment of fee |