HUP9601442A2 - Új, nimeszulidot tartalmazó gyulladásgátló és analgetikus gyógyászati készítmények, valamint eljárás ezek előállítására - Google Patents

Új, nimeszulidot tartalmazó gyulladásgátló és analgetikus gyógyászati készítmények, valamint eljárás ezek előállítására

Info

Publication number
HUP9601442A2
HUP9601442A2 HU9601442A HUP9601442A HUP9601442A2 HU P9601442 A2 HUP9601442 A2 HU P9601442A2 HU 9601442 A HU9601442 A HU 9601442A HU P9601442 A HUP9601442 A HU P9601442A HU P9601442 A2 HUP9601442 A2 HU P9601442A2
Authority
HU
Hungary
Prior art keywords
weight
nimesulide
preparation
added
mixture
Prior art date
Application number
HU9601442A
Other languages
English (en)
Inventor
Singh Amarjit
Jain Rajesh
Original Assignee
Panacea Biotec Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IN2048DE1995 external-priority patent/IN186558B/en
Application filed by Panacea Biotec Limited filed Critical Panacea Biotec Limited
Publication of HU9601442D0 publication Critical patent/HU9601442D0/hu
Publication of HUP9601442A2 publication Critical patent/HUP9601442A2/hu
Publication of HUP9601442A3 publication Critical patent/HUP9601442A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát transzdermálisan alkalmazható gyűlladásgátló ésanalgetikűs hatású nimeszűlidőt tartalmazó gyógyászati készítményekképezik. A készítmények nimeszűlidőt (01-10 tömeg%) és perkűtán abszőrpciótfőkőzó vivőanyagőt (90-99,9 tömeg%) tartalmaznak. A készítmény kívánt esetben semlegesítő/pH-beállító szert istartalmazhat, amelynek mennyisége 0,0-2,0 tömeg%. A találmány tárgyát képezi tővábbá eljárás a találmány szerintigyógyászati készítmények előállítására, amely abban áll, hőgy i) 0,5-30 tömeg% perkűtán abszőrpciót főkőzó anyagőt 2,5-30 tömeg%mennyiségű, egy vagy több vivő- vagy hőrdőzóanyaggal elegyítenek, ii) az i) lépésben kapőtt elegyhez 0,1-10 tömeg% nimeszűlidőt adnak, és azelegyet a nimeszűlid teljes őldódásáig keverik, iii) az előzőektől elkülönítetten 0,5-12 tömeg% felületaktív szert, 0,2-50tömeg% gélesítő/sűrítőanyagőt és 2,5-30 tömeg% egy vagy több vivő-/hőrdőzóanyagőt elegyítenek, és az elegyet hőmőgenizálják, iv) majd a ii) lépésben kapőtt elegyet a iii) lépésben kapőtt hőmőgenizáltelegyhez adják keverés mellett, így nyerik a kívánt analgetikűskészítményt, és kívánt esetben a iv) lépésben a készítményhez egysemlegelítő/pH-szabályőzó szert adnak. A találmány szerinti készítményből a nimeszűlid[N-(4-nitrő-2-fenőxi-fenil-metán-szűlfőnamid)] bőrön át felszívódik. ŕ
HU9601442A 1995-07-25 1996-05-29 Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them HUP9601442A3 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
IN1389DE1995 1995-07-25
IN2047DE1995 1995-11-08
IN2046DE1995 1995-11-08
IN2048DE1995 IN186558B (hu) 1995-07-25 1995-11-08
EP96304461A EP0812591B1 (en) 1995-07-25 1996-06-14 Injectable compositions containing Nimesulide
NZ299481A NZ299481A (en) 1995-07-25 1996-10-01 Pharmaceutical composition comprising nimesulide (4-nitro, 2-phenoxyphenylmethanesulphonamide)
AU67993/96A AU693720B2 (en) 1995-07-25 1996-10-02 Novel therapeutic injectable analgesic pharmaceutical composition containing Nimesulide 4-Nitro,2 Phenoxyphenyl Methane Sulphonamide for intramuscular administration
NO964189A NO303619B1 (no) 1995-07-25 1996-10-03 Smertestillende og anti-inflammatorisk middel inneholdende nimesulid samt fremgangsmÕte ved fremstilling derav
CA002188703A CA2188703C (en) 1995-07-25 1996-10-24 Therapeutic injectable analgesic pharmaceutical composition containing nimesulide 4-nitro, 2-phenoxyphenyl methane sulphonamide for intramuscular administration
CZ963166A CZ316696A3 (cs) 1995-07-25 1996-10-29 Nový injektovatelný analgetický farmaceutický prostředek obsahující nimesulid N-(4-nitro, 2-fenoxyfenyl)methansulfonamid pro nitrosvalové podávání a způsob jeho přípravy
JP8290585A JP2875988B2 (ja) 1995-07-25 1996-10-31 ４−ニトロ−２−フェノキシフェニルメタンスルホンアミドであるニメスリドを含む、新規な筋肉内投与用の注射可能な鎮痛薬剤組成物

Publications (3)

Publication Number Publication Date
HU9601442D0 HU9601442D0 (en) 1996-07-29
HUP9601442A2 true HUP9601442A2 (hu) 1998-04-28
HUP9601442A3 HUP9601442A3 (en) 1999-03-29

Family

ID=27581364

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9601442A HUP9601442A3 (en) 1995-07-25 1996-05-29 Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them

Country Status (9)

Country Link
US (2) US5688829A (hu)
EP (1) EP0812591B1 (hu)
JP (1) JP2875988B2 (hu)
AU (1) AU693720B2 (hu)
CA (1) CA2188703C (hu)
CZ (1) CZ316696A3 (hu)
HU (1) HUP9601442A3 (hu)
NO (1) NO303619B1 (hu)
NZ (1) NZ299481A (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291278B1 (it) * 1996-07-05 1999-01-07 Errekappa Euroterapici S P A Preparazione farmaceutica a base di nimesulide per uso topico
IT1289972B1 (it) * 1997-02-25 1998-10-19 Helsinn Healthcare Sa Formulazioni topiche di nimesulide in forma di sistemi a cristalli liquidi
IT1289973B1 (it) 1997-02-25 1998-10-19 Helsinn Healthcare Sa Sistemi gelificati di nimesulide per uso topico
IT1291895B1 (it) * 1997-04-24 1999-01-21 Errekappa Euroterapici S P A Preparazione farmaceutica fluida a base di nimesulide per uso orale e rinofaringeo
US6214318B1 (en) 1997-10-02 2001-04-10 Oms Holdings Llc Aerosol ointment compositions for topical use
IN188720B (hu) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
AU718356B2 (en) * 1998-01-12 2000-04-13 Panacea Biotec Limited A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
IN187306B (hu) * 1998-01-12 2002-03-23 Panacea Biotec Ltd
GB2340751B (en) * 1998-08-12 2003-11-05 Edko Trading Representation Pharmaceutical compositions
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
WO2000072884A1 (en) * 1999-05-31 2000-12-07 Dinesh Shantilal Patel A novel formulation of n-(4-nitro-2-phenoxyphenyl)methanesulfonamide
AU5325000A (en) 1999-06-05 2000-12-28 David Houze Solubility enhancement of drugs in transdermal drug delivery systems and methodsof use
US20020004065A1 (en) 2000-01-20 2002-01-10 David Kanios Compositions and methods to effect the release profile in the transdermal administration of active agents
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
DE10125883A1 (de) 2001-05-28 2002-12-12 Serumwerk Bernburg Ag Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
EP2015740A4 (en) * 2006-04-24 2009-11-11 Panacea Biotec Ltd NEW LOW-DOSED PHARMACEUTICAL COMPOSITIONS WITH NIMESULID, PREPARATION AND USE
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
EA023000B1 (ru) * 2012-10-25 2016-04-29 Закрытое Акционерное Общество "Фармфирма "Сотекс" Наружное средство для лечения болезней суставов и мягких тканей
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840597A (en) * 1971-02-24 1974-10-08 Riker Laboratories Inc Substituted 2-phenoxy alkane-sulfonanilides
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
CA1248450A (en) * 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IT1248475B (it) * 1990-05-22 1995-01-19 Angeli Inst Spa Composti di inclusione di nimesulide con ciclodestrine
HU209605B (en) * 1991-04-15 1994-09-28 Chinoin Gyogyszer Es Vegyeszet Process for production of wather-free transdermal preparation
IT1251838B (it) * 1991-09-20 1995-05-26 Lpb Ist Farm Uso della nimesulide nel trattamento della cataratta
HU210922B (en) * 1993-05-24 1995-09-28 Europharmaceuticals Sa Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them
BE1008307A3 (fr) * 1994-06-16 1996-04-02 Europharmaceuticals Sa Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.

Also Published As

Publication number Publication date
NO964189L (no) 1998-04-06
US5688829A (en) 1997-11-18
HUP9601442A3 (en) 1999-03-29
JP2875988B2 (ja) 1999-03-31
CA2188703C (en) 2001-04-24
EP0812591B1 (en) 2003-09-10
AU6799396A (en) 1998-04-09
CA2188703A1 (en) 1998-04-24
EP0812591A1 (en) 1997-12-17
AU693720B2 (en) 1998-07-02
JPH10130143A (ja) 1998-05-19
HU9601442D0 (en) 1996-07-29
NO303619B1 (no) 1998-08-10
CZ316696A3 (cs) 1998-05-13
US5716609A (en) 1998-02-10
NO964189D0 (no) 1996-10-03
NZ299481A (en) 1997-09-22

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