HUP0500163A2 - Pirazolo [5,1-b] kinazolin származékok és ezeket tartalmazó gyógyszerkészítmények mint az IMPDH enzim inhibitorai - Google Patents

Pirazolo [5,1-b] kinazolin származékok és ezeket tartalmazó gyógyszerkészítmények mint az IMPDH enzim inhibitorai

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Publication number
HUP0500163A2
HUP0500163A2 HU0500163A HUP0500163A HUP0500163A2 HU P0500163 A2 HUP0500163 A2 HU P0500163A2 HU 0500163 A HU0500163 A HU 0500163A HU P0500163 A HUP0500163 A HU P0500163A HU P0500163 A2 HUP0500163 A2 HU P0500163A2
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HU
Hungary
Prior art keywords
group
pyrazolo
inhibitors
pharmaceutical compositions
carbonyl
Prior art date
Application number
HU0500163A
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English (en)
Inventor
Ping Chen
Murali Dhar T.G.
Edwin J. Iwanowicz
Scott H. Watterson
Henry H. Gu
Yufen Zhao
Original Assignee
Bristol-Myers Squibb Company
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Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP0500163A2 publication Critical patent/HUP0500163A2/hu
Publication of HUP0500163A3 publication Critical patent/HUP0500163A3/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

A találmány tárgyát általános képletű vegyületek - ahol R3hidrogénatom, hidroxi- vagy aminocsoport; R30 oxo- (=O) vagy tioxo-(=S) csoport; W karbonil-, szulfinil- vagy szulfonilcsoport; Xmetilén- vagy -N(R4)- általános képletű csoport vagy oxigénatom; vagykarbonilcsoport, ha W metiléncsoport; Y kémiai kötés vagy -C(R40)(R45)- általános képletű csoport; Q összekötő csoport; Z adottesetben szubsztituált alkil-, alkenil-, alkinil-, cikloalkil-, aril-,heteroaril- vagy heterociklilcsoport; és X1, X2, X3, X4, X5, X6, X7,X8, X9, X10 és X11 triciklikus heteroaril gyűrűrendszer képzésétlehetővé tevő csoport - és enantiomereik, diasztereomereik,tautomereik és elfogadható sóik, szolvátjaik vagy prodrogjaik,alkalmazásuk és ezeket tartalmazó, az inozin-monofoszfát dehidrogenázenzimmel összefüggő rendellenességek kezelésére szolgálógyógyszerkészítmények képezik. Ó
HU0500163A 2001-12-21 2002-12-20 Pyrazolo [5,1-b]quinazoline derivatives and pharmaceutical compositions thereof as inhibitors of impdh enzyme HUP0500163A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34323401P 2001-12-21 2001-12-21
PCT/US2002/041186 WO2003055447A2 (en) 2001-12-21 2002-12-20 Heterocyclic acridone inhibitors of impdh enzyme

Publications (2)

Publication Number Publication Date
HUP0500163A2 true HUP0500163A2 (hu) 2005-05-30
HUP0500163A3 HUP0500163A3 (en) 2012-07-30

Family

ID=23345248

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0500163A HUP0500163A3 (en) 2001-12-21 2002-12-20 Pyrazolo [5,1-b]quinazoline derivatives and pharmaceutical compositions thereof as inhibitors of impdh enzyme
HU0500574A HUP0500574A3 (en) 2001-12-21 2002-12-20 Acridone inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0500574A HUP0500574A3 (en) 2001-12-21 2002-12-20 Acridone inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use

Country Status (13)

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US (2) US7312209B2 (hu)
EP (2) EP1456207A4 (hu)
JP (2) JP4546090B2 (hu)
AT (1) ATE441414T1 (hu)
AU (2) AU2002360797A1 (hu)
DE (1) DE60233592D1 (hu)
ES (1) ES2330839T3 (hu)
HU (2) HUP0500163A3 (hu)
PE (1) PE20030894A1 (hu)
PL (2) PL371348A1 (hu)
TW (1) TW200301698A (hu)
UY (1) UY27597A1 (hu)
WO (2) WO2003059269A2 (hu)

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