HUP0303795A2 - Aromatáz inhibitorok alkalmazása a fogamzás elősegítésének fokozására alkalmas gyógyszerkészítmény előállítására - Google Patents

Aromatáz inhibitorok alkalmazása a fogamzás elősegítésének fokozására alkalmas gyógyszerkészítmény előállítására

Info

Publication number
HUP0303795A2
HUP0303795A2 HU0303795A HUP0303795A HUP0303795A2 HU P0303795 A2 HUP0303795 A2 HU P0303795A2 HU 0303795 A HU0303795 A HU 0303795A HU P0303795 A HUP0303795 A HU P0303795A HU P0303795 A2 HUP0303795 A2 HU P0303795A2
Authority
HU
Hungary
Prior art keywords
preparation
enhance
pharmaceutical composition
composition suitable
aromatase inhibitors
Prior art date
Application number
HU0303795A
Other languages
English (en)
Inventor
Robert F. Casper
Mohamed F.M. Mitwally
Original Assignee
Ares Trading S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading S.A. filed Critical Ares Trading S.A.
Publication of HUP0303795A2 publication Critical patent/HUP0303795A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya legalább egy aromatáz inhibitor alkalmazásafogamzást elősegítő kezelés alá vetett női betegeknél az implantációés a terhesség arányának javítására alkalmas gyógyszerkészítményelőállítására, amely egy vagy több napi dózis aromatáz inhibitorttartalmaz, és amely a fogamzást elősegítő ciklus vagy peteéréststimuláló ciklus során adagolható, és ahol az aromatáz inhibitordózisa a szérum ösztradiol szintjének csökkentésére elegendőmennyiség. A találmány kiterjed az ilyen gyógyszerkészítményekre ésezeket tartalmazó készletre. Ó
HU0303795A 2001-04-17 2002-04-17 Aromatáz inhibitorok alkalmazása a fogamzás elősegítésének fokozására alkalmas gyógyszerkészítmény előállítására HUP0303795A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28417801P 2001-04-17 2001-04-17
PCT/CA2002/000522 WO2002083240A1 (en) 2001-04-17 2002-04-17 Aromatase inhibition to enhance assisted reproduction

Publications (1)

Publication Number Publication Date
HUP0303795A2 true HUP0303795A2 (hu) 2004-03-29

Family

ID=23089175

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303795A HUP0303795A2 (hu) 2001-04-17 2002-04-17 Aromatáz inhibitorok alkalmazása a fogamzás elősegítésének fokozására alkalmas gyógyszerkészítmény előállítására

Country Status (33)

Country Link
US (1) US7846957B2 (hu)
EP (1) EP1381431B1 (hu)
JP (1) JP2004526764A (hu)
KR (1) KR20040012751A (hu)
CN (1) CN100377710C (hu)
AR (1) AR034310A1 (hu)
AT (1) ATE363906T1 (hu)
AU (1) AU2002249041B2 (hu)
BG (1) BG108316A (hu)
BR (1) BR0208968A (hu)
CA (1) CA2444932A1 (hu)
CY (1) CY1108021T1 (hu)
CZ (1) CZ299735B6 (hu)
DE (1) DE60220516T2 (hu)
DK (1) DK1381431T3 (hu)
EA (1) EA010354B1 (hu)
EE (1) EE200300512A (hu)
ES (1) ES2283541T3 (hu)
HK (1) HK1067987A1 (hu)
HR (1) HRP20030838A2 (hu)
HU (1) HUP0303795A2 (hu)
IL (2) IL158395A0 (hu)
MX (1) MXPA03009446A (hu)
NO (1) NO20034245L (hu)
NZ (1) NZ528501A (hu)
PL (1) PL366554A1 (hu)
PT (1) PT1381431E (hu)
SI (1) SI1381431T1 (hu)
SK (1) SK14252003A3 (hu)
UA (1) UA79591C2 (hu)
WO (1) WO2002083240A1 (hu)
YU (1) YU81303A (hu)
ZA (1) ZA200307514B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2491372A1 (en) * 2002-07-02 2004-01-15 Pharmacia & Upjohn Company Llc Infertility treatment with exemestane
AU2011256088B2 (en) 2010-05-20 2015-03-26 University Of Saskatchewan Use of aromatase inhibitors for synchronizing ovulation, inducing superovulation or double ovulation and improving twinning and fertility in a mammal
WO2012127501A2 (en) * 2011-03-11 2012-09-27 Sanzyme Limited Composition for improving endometrial thickness during ovarian stimulation
JP6280501B2 (ja) 2011-09-08 2018-02-14 メレオ バイオファーマ ２ リミテッド 性腺機能低下症および関連疾患の処置ためのアロマターゼ阻害剤の使用
US10004723B2 (en) 2013-04-19 2018-06-26 University Of Saskatchewan Aromatase inhibitor-releasing intravaginal device
CN107648594A (zh) * 2017-11-08 2018-02-02 广州市桐晖药业有限公司 枸橼酸氯米芬胶囊及其制备方法
CN118286143A (zh) * 2024-03-20 2024-07-05 郑州大学第三附属医院(河南省妇幼保健院) 注射用尿促卵泡素联合来曲唑在制备不孕症的试剂盒中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4845227A (en) * 1984-06-18 1989-07-04 Eli Lilly And Company Aromatase inhibitors from azoles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
DE4330237C2 (de) * 1993-09-02 1995-11-30 Schering Ag 1-Methylsubstituierte Androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE59703511D1 (de) 1996-03-29 2001-06-13 S W Patentverwaltungs Ges M B Kosmetikum bzw. kosmetikzusammensetzung zur glättung und straffung der haut bei gestörtem unterhaut-binde-fettgewebe, insbesondere bei der "cellulite"
WO1997040846A1 (en) 1996-04-30 1997-11-06 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
DE19622457A1 (de) 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
WO1998058657A1 (en) * 1997-06-20 1998-12-30 Akzo Nobel N.V. Gonadotropin releasing hormone antagonist
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation

Also Published As

Publication number Publication date
HRP20030838A2 (en) 2005-08-31
WO2002083240A1 (en) 2002-10-24
CY1108021T1 (el) 2013-09-04
DE60220516D1 (de) 2007-07-19
ES2283541T3 (es) 2007-11-01
ATE363906T1 (de) 2007-06-15
EP1381431A1 (en) 2004-01-21
DK1381431T3 (da) 2007-10-08
EP1381431B1 (en) 2007-06-06
JP2004526764A (ja) 2004-09-02
CZ299735B6 (cs) 2008-11-05
EE200300512A (et) 2004-02-16
CN100377710C (zh) 2008-04-02
IL158395A (en) 2009-06-15
CA2444932A1 (en) 2002-10-24
CN1549734A (zh) 2004-11-24
SI1381431T1 (sl) 2007-08-31
UA79591C2 (en) 2007-07-10
DE60220516T2 (de) 2007-10-11
EA200301129A1 (ru) 2004-04-29
BG108316A (bg) 2004-12-30
AR034310A1 (es) 2004-02-18
MXPA03009446A (es) 2004-05-24
US20040204393A1 (en) 2004-10-14
IL158395A0 (en) 2004-05-12
WO2002083240A9 (en) 2004-05-06
NO20034245L (no) 2003-12-15
HK1067987A1 (en) 2005-04-22
NO20034245D0 (no) 2003-09-23
NZ528501A (en) 2008-04-30
SK14252003A3 (sk) 2004-03-02
BR0208968A (pt) 2004-04-27
YU81303A (sh) 2006-05-25
KR20040012751A (ko) 2004-02-11
ZA200307514B (en) 2004-09-27
EA010354B1 (ru) 2008-08-29
PT1381431E (pt) 2007-07-03
CZ20033108A3 (en) 2004-06-16
AU2002249041B2 (en) 2007-07-12
PL366554A1 (en) 2005-02-07
US7846957B2 (en) 2010-12-07

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees