DE60220516D1 - Aromatase hemmung zur steigerung der implantationsrate - Google Patents

Aromatase hemmung zur steigerung der implantationsrate

Info

Publication number
DE60220516D1
DE60220516D1 DE60220516T DE60220516T DE60220516D1 DE 60220516 D1 DE60220516 D1 DE 60220516D1 DE 60220516 T DE60220516 T DE 60220516T DE 60220516 T DE60220516 T DE 60220516T DE 60220516 D1 DE60220516 D1 DE 60220516D1
Authority
DE
Germany
Prior art keywords
increase
aromatase inhibition
implant
rate
implant rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60220516T
Other languages
English (en)
Other versions
DE60220516T2 (de
Inventor
Robert F Casper
Mohamed F Mitwally
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ares Trading SA
Original Assignee
Ares Trading SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading SA filed Critical Ares Trading SA
Publication of DE60220516D1 publication Critical patent/DE60220516D1/de
Application granted granted Critical
Publication of DE60220516T2 publication Critical patent/DE60220516T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60220516T 2001-04-17 2002-04-17 Aromatasehemmung zum Verbessern assistierter Reproduktion Expired - Lifetime DE60220516T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28417801P 2001-04-17 2001-04-17
US284178P 2001-04-17
PCT/CA2002/000522 WO2002083240A1 (en) 2001-04-17 2002-04-17 Aromatase inhibition to enhance assisted reproduction

Publications (2)

Publication Number Publication Date
DE60220516D1 true DE60220516D1 (de) 2007-07-19
DE60220516T2 DE60220516T2 (de) 2007-10-11

Family

ID=23089175

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60220516T Expired - Lifetime DE60220516T2 (de) 2001-04-17 2002-04-17 Aromatasehemmung zum Verbessern assistierter Reproduktion

Country Status (33)

Country Link
US (1) US7846957B2 (de)
EP (1) EP1381431B1 (de)
JP (1) JP2004526764A (de)
KR (1) KR20040012751A (de)
CN (1) CN100377710C (de)
AR (1) AR034310A1 (de)
AT (1) ATE363906T1 (de)
AU (1) AU2002249041B2 (de)
BG (1) BG108316A (de)
BR (1) BR0208968A (de)
CA (1) CA2444932A1 (de)
CY (1) CY1108021T1 (de)
CZ (1) CZ299735B6 (de)
DE (1) DE60220516T2 (de)
DK (1) DK1381431T3 (de)
EA (1) EA010354B1 (de)
EE (1) EE200300512A (de)
ES (1) ES2283541T3 (de)
HK (1) HK1067987A1 (de)
HR (1) HRP20030838A2 (de)
HU (1) HUP0303795A2 (de)
IL (2) IL158395A0 (de)
MX (1) MXPA03009446A (de)
NO (1) NO20034245L (de)
NZ (1) NZ528501A (de)
PL (1) PL366554A1 (de)
PT (1) PT1381431E (de)
SI (1) SI1381431T1 (de)
SK (1) SK14252003A3 (de)
UA (1) UA79591C2 (de)
WO (1) WO2002083240A1 (de)
YU (1) YU81303A (de)
ZA (1) ZA200307514B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0312393A (pt) * 2002-07-02 2005-04-12 Pharmacia & Upjohn Co Llc Tratamento de infertilidade com exemestano
AU2011256088B2 (en) * 2010-05-20 2015-03-26 University Of Saskatchewan Use of aromatase inhibitors for synchronizing ovulation, inducing superovulation or double ovulation and improving twinning and fertility in a mammal
WO2012127501A2 (en) * 2011-03-11 2012-09-27 Sanzyme Limited Composition for improving endometrial thickness during ovarian stimulation
PT2753312T (pt) * 2011-09-08 2017-02-03 Mereo Biopharma 2 Ltd Utilização de um inibidor da aromatase para o tratamento de hipogonadismo e doenças relacionadas
US10004723B2 (en) 2013-04-19 2018-06-26 University Of Saskatchewan Aromatase inhibitor-releasing intravaginal device
CN107648594A (zh) * 2017-11-08 2018-02-02 广州市桐晖药业有限公司 枸橼酸氯米芬胶囊及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4845227A (en) * 1984-06-18 1989-07-04 Eli Lilly And Company Aromatase inhibitors from azoles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
DE4330237C2 (de) * 1993-09-02 1995-11-30 Schering Ag 1-Methylsubstituierte Androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
ATE200978T1 (de) 1996-03-29 2001-05-15 S W Patentverwertungs Ges M B KOSMETIKUM BZW. KOSMETIKZUSAMMENSETZUNG ZUR GLÄTTUNG UND STRAFFUNG DER HAUT BEI GESTÖRTEM UNTERHAUT-BINDE-FETTGEWEBE, INSBESONDERE BEI DER ßCELLULITEß
CA2250908C (en) 1996-04-30 2012-03-13 Takeda Chemical Industries, Ltd. Combined use of gnrh agonist and antagonist
DE19622457A1 (de) 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
DE69831241T2 (de) * 1997-06-20 2006-03-23 Akzo Nobel N.V. Gonadotropin freisetzendes Hormon Antagonist
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation

Also Published As

Publication number Publication date
UA79591C2 (en) 2007-07-10
CA2444932A1 (en) 2002-10-24
WO2002083240A9 (en) 2004-05-06
CN1549734A (zh) 2004-11-24
EE200300512A (et) 2004-02-16
JP2004526764A (ja) 2004-09-02
SI1381431T1 (sl) 2007-08-31
YU81303A (sh) 2006-05-25
CN100377710C (zh) 2008-04-02
HUP0303795A2 (hu) 2004-03-29
MXPA03009446A (es) 2004-05-24
KR20040012751A (ko) 2004-02-11
US20040204393A1 (en) 2004-10-14
BG108316A (bg) 2004-12-30
SK14252003A3 (sk) 2004-03-02
PT1381431E (pt) 2007-07-03
AR034310A1 (es) 2004-02-18
CZ20033108A3 (en) 2004-06-16
CY1108021T1 (el) 2013-09-04
NZ528501A (en) 2008-04-30
NO20034245D0 (no) 2003-09-23
DE60220516T2 (de) 2007-10-11
US7846957B2 (en) 2010-12-07
EP1381431B1 (de) 2007-06-06
ATE363906T1 (de) 2007-06-15
CZ299735B6 (cs) 2008-11-05
DK1381431T3 (da) 2007-10-08
AU2002249041B2 (en) 2007-07-12
BR0208968A (pt) 2004-04-27
IL158395A0 (en) 2004-05-12
WO2002083240A1 (en) 2002-10-24
ES2283541T3 (es) 2007-11-01
EA010354B1 (ru) 2008-08-29
PL366554A1 (en) 2005-02-07
IL158395A (en) 2009-06-15
NO20034245L (no) 2003-12-15
EP1381431A1 (de) 2004-01-21
HK1067987A1 (en) 2005-04-22
HRP20030838A2 (en) 2005-08-31
ZA200307514B (en) 2004-09-27
EA200301129A1 (ru) 2004-04-29

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