HUP0302671A2 - Indol-3-il-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Indol-3-il-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302671A2 HUP0302671A2 HU0302671A HUP0302671A HUP0302671A2 HU P0302671 A2 HUP0302671 A2 HU P0302671A2 HU 0302671 A HU0302671 A HU 0302671A HU P0302671 A HUP0302671 A HU P0302671A HU P0302671 A2 HUP0302671 A2 HU P0302671A2
- Authority
- HU
- Hungary
- Prior art keywords
- het
- nhr6
- conh
- hal
- group
- Prior art date
Links
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 101150009274 nhr-1 gene Proteins 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A találmány szerinti vegyületek (I) általános képletében A és Bjelentése egymástól függetlenül O, S, NH, NR7, CO, CONH, NHCO vagyközvetlen kötés, X jelentése adott esetben R4 vagy R5 csoporttalmonoszubsztituált 1vagy 2 szénatomos alkiléncsoport vagy közvetlenkötés, R1 jelentése H, Z vagy -(CH2)o-Ar, R2 jelentése H, R' vagy -C(O)Z, R3 jelentése -NHR6, -NR6-C(=NR6)-NHR6, -C(=NR6)-NHR6, -NR6-C(=NR9)-NHR6, -C(=NR9)-NHR6 vagy Het1, R4 és R5 jelentése egymástólfüggetlenül H, oxocsoport; R7, -(CH2)o-Ar, -C(O)-(CH2)o-Ar, -C(O)-(CH2)o-R7, -C(O)-(CH2)o-Het, Het, NHR6, NHAr, NH-Het, CONH-R7, CONH-(CH2)o-Ar, CONH-(CH2)o-Het, OR7, OAr, OR6 vagy O-Het, R6 jelentése H,-C(O)R7, -C(O)-Ar, -C(O)-Het, R7, COOR7, COO-(CH2)o-Ar, COO-(CH2)o-Het, SO2-Ar, SO2R7 vagy SO2-Het, R7 jelentése 1-10 szénatomosalkilcsoport vagy 3-10 szénatomos cikloalkilcsoport, R8 jelentése Hal,NO2, CN, Z, -(CH2)o-Ar, COOR1, OR1, CF3, OCF3, SO2R1, NHR1, N(R1)2,NH-C(O)R1, NHCOOR1, COOH, COOZ vagy C(O)R1, R9 jelentése CN vagy NO2,Z jelentése 1-6 szénatomos alkilcsoport; Ar jelentése adott esetbenegy vagy több R8 csoporttal szubsztituált Hal jelentése fluoratom,klóratom, brómatom vagy jódatom, Het jelentése telített, részben vagyegészen telítetlen mono- vagy biciklusos, 5-10 tagú heterociklusoscsoport, amely 1 vagy 2 nitrogénatomot és/vagy 1 vagy 2 kénatomot vagyoxigénatomot tartalmaz, és amely adott esetben 1 vagy 2 R8 csoporttalszubsztituálva lehet, Het1 jelentése telített, részben vagy egészentelítetlen; mono- vagy biciklusos, 5-10 tagú heterociklusos csoport,amely 1-4 nitrogénatomot tartalmaz, és amely adott esetben 1 vagy 2Hal, R7, OR7, CN, NHZ, oxocsoport vagy NO2 szubsztituensselszubsztituálva lehet, n értéke 0, 1 vagy 2, m értéke 0, 1, 2, 3, 4, 5vagy 6, o értéke 0, 1 vagy 2, valamint ezek fiziológiailagalkalmazható sói és szolvátjai. A találmány kiterjed a fentivegyületek előállítására és gyógyszerként történő alkalmazására. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10006139A DE10006139A1 (de) | 2000-02-11 | 2000-02-11 | Indol-3-yl-Derivate |
| PCT/EP2001/000084 WO2001058893A2 (de) | 2000-02-11 | 2001-01-05 | Indol-3-yl-derivate und deren verwendung als integrin-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0302671A2 true HUP0302671A2 (hu) | 2003-12-29 |
Family
ID=7630611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302671A HUP0302671A2 (hu) | 2000-02-11 | 2001-01-05 | Indol-3-il-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6743810B2 (hu) |
| EP (1) | EP1254133B9 (hu) |
| JP (1) | JP4938194B2 (hu) |
| KR (1) | KR20020073585A (hu) |
| CN (1) | CN1214026C (hu) |
| AR (1) | AR027398A1 (hu) |
| AT (1) | ATE293620T1 (hu) |
| AU (2) | AU2001231664C1 (hu) |
| BR (1) | BR0108154A (hu) |
| CA (1) | CA2399813C (hu) |
| CO (1) | CO5261548A1 (hu) |
| CZ (1) | CZ20022616A3 (hu) |
| DE (2) | DE10006139A1 (hu) |
| EC (1) | ECSP013923A (hu) |
| ES (1) | ES2240400T3 (hu) |
| HK (1) | HK1051863A1 (hu) |
| HU (1) | HUP0302671A2 (hu) |
| IL (1) | IL151154A0 (hu) |
| MX (1) | MXPA02007732A (hu) |
| NO (1) | NO20023770D0 (hu) |
| NZ (1) | NZ521260A (hu) |
| PE (1) | PE20011125A1 (hu) |
| PL (1) | PL356427A1 (hu) |
| PT (1) | PT1254133E (hu) |
| RU (1) | RU2257380C2 (hu) |
| SK (1) | SK11152002A3 (hu) |
| WO (1) | WO2001058893A2 (hu) |
| ZA (1) | ZA200207273B (hu) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
| US20040138284A1 (en) * | 2000-02-11 | 2004-07-15 | Matthias Wiesner | Indol-3-yl derivatives |
| CA2419255A1 (en) * | 2000-08-29 | 2002-03-07 | Ish Kumar Khanna | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
| KR20030061390A (ko) * | 2000-11-01 | 2003-07-18 | 메르크 파텐트 게엠베하 | 안구 질환 치료용 조성물 및 방법 |
| GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
| NZ539682A (en) * | 2001-01-29 | 2006-03-31 | Dimensional Pharm Inc | Substituted indoles and their use as integrin antagonists |
| US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
| MXPA04000839A (es) | 2001-08-01 | 2004-05-14 | Merck Patent Gesellscahft Mit | Metodos y composiciones para el tratamiento de enfermedades oftalmicas. |
| CN1658894A (zh) * | 2002-02-14 | 2005-08-24 | 默克专利股份有限公司 | 用于治疗眼病的方法和组合物 |
| CA2521135A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | N-containing heteroaromatic compounds as modulators of ppars and methods of treating metabolic disorders |
| EP1620088A4 (en) * | 2003-04-28 | 2007-08-29 | Bayer Pharmaceuticals Corp | ACETIC INDOLE ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS |
| US7211588B2 (en) | 2003-07-25 | 2007-05-01 | Zentaris Gmbh | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation |
| DE10337863A1 (de) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Verwendung von Chromen-4-on-Derivaten |
| PL1667668T3 (pl) * | 2003-10-01 | 2008-10-31 | Merck Patent Gmbh | Antagoniści integryny alfavbeta3 oraz alfavbeta6 jako czynniki przeciwzwłóknieniowe |
| WO2005105785A2 (en) * | 2004-05-04 | 2005-11-10 | Novo Nordisk A/S | Indole derivatives for treatment of obesity |
| US8003806B2 (en) * | 2004-11-12 | 2011-08-23 | OSI Pharmaceuticals, LLC | Integrin antagonists useful as anticancer agents |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| CN102335168B (zh) * | 2011-10-25 | 2014-04-02 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗骨质疏松药物中的应用 |
| AR094812A1 (es) * | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| MX369646B (es) | 2014-08-18 | 2019-11-15 | Eisai R&D Man Co Ltd | Sal de derivado de piridina monociclico y su cristal. |
| JPWO2019189241A1 (ja) | 2018-03-28 | 2021-03-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝細胞癌治療剤 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT290523B (de) * | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| GB1148908A (en) * | 1965-04-19 | 1969-04-16 | Sumitomo Chemical Co | Indole derivatives and processes for making them |
| US4824850A (en) * | 1982-05-18 | 1989-04-25 | University Of Florida | Brain-specific drug delivery |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| IT1244548B (it) * | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche |
| GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| JP2000508319A (ja) | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αｖβ３拮抗薬 |
| ATE234281T1 (de) * | 1996-08-27 | 2003-03-15 | Wyeth Corp | 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden |
| WO1999033798A1 (fr) * | 1997-12-25 | 1999-07-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives heterocycliques azotes |
| EP1056452B1 (en) * | 1998-02-23 | 2006-07-19 | South Alabama Medical Science Foundation | Indole-3-propionic acids, salts and esters thereof used as medicaments |
| CA2322162A1 (en) * | 1998-02-25 | 1999-09-02 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| PT1068184E (pt) * | 1998-04-08 | 2002-12-31 | Wyeth Corp | Derivados n-ariloxietilamina para o tratamento de depressao |
| AU3386199A (en) * | 1998-04-08 | 1999-10-25 | American Home Products Corporation | N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents) |
| JP4425699B2 (ja) * | 2004-05-17 | 2010-03-03 | 川崎重工業株式会社 | 小型滑走艇 |
-
2000
- 2000-02-11 DE DE10006139A patent/DE10006139A1/de not_active Withdrawn
-
2001
- 2001-01-05 NZ NZ521260A patent/NZ521260A/en unknown
- 2001-01-05 CZ CZ20022616A patent/CZ20022616A3/cs unknown
- 2001-01-05 CN CNB018046703A patent/CN1214026C/zh not_active Expired - Fee Related
- 2001-01-05 WO PCT/EP2001/000084 patent/WO2001058893A2/de active IP Right Grant
- 2001-01-05 JP JP2001558443A patent/JP4938194B2/ja not_active Expired - Fee Related
- 2001-01-05 IL IL15115401A patent/IL151154A0/xx unknown
- 2001-01-05 AT AT01903624T patent/ATE293620T1/de not_active IP Right Cessation
- 2001-01-05 AU AU2001231664A patent/AU2001231664C1/en not_active Ceased
- 2001-01-05 US US10/203,406 patent/US6743810B2/en not_active Expired - Fee Related
- 2001-01-05 ES ES01903624T patent/ES2240400T3/es not_active Expired - Lifetime
- 2001-01-05 PT PT01903624T patent/PT1254133E/pt unknown
- 2001-01-05 AU AU3166401A patent/AU3166401A/xx active Pending
- 2001-01-05 BR BR0108154-3A patent/BR0108154A/pt not_active IP Right Cessation
- 2001-01-05 HU HU0302671A patent/HUP0302671A2/hu unknown
- 2001-01-05 DE DE50105955T patent/DE50105955D1/de not_active Expired - Lifetime
- 2001-01-05 CA CA002399813A patent/CA2399813C/en not_active Expired - Fee Related
- 2001-01-05 PL PL01356427A patent/PL356427A1/xx unknown
- 2001-01-05 RU RU2002123332/04A patent/RU2257380C2/ru not_active IP Right Cessation
- 2001-01-05 SK SK1115-2002A patent/SK11152002A3/sk not_active Application Discontinuation
- 2001-01-05 EP EP01903624A patent/EP1254133B9/de not_active Expired - Lifetime
- 2001-01-05 KR KR1020027010302A patent/KR20020073585A/ko not_active Application Discontinuation
- 2001-01-05 MX MXPA02007732A patent/MXPA02007732A/es unknown
- 2001-02-09 EC EC2001003923A patent/ECSP013923A/es unknown
- 2001-02-09 AR ARP010100595A patent/AR027398A1/es not_active Application Discontinuation
- 2001-02-09 CO CO01009901A patent/CO5261548A1/es not_active Application Discontinuation
- 2001-02-09 PE PE2001000143A patent/PE20011125A1/es not_active Application Discontinuation
-
2002
- 2002-08-09 NO NO20023770A patent/NO20023770D0/no not_active Application Discontinuation
- 2002-09-10 ZA ZA200207273A patent/ZA200207273B/en unknown
-
2003
- 2003-06-11 HK HK03104148A patent/HK1051863A1/xx not_active IP Right Cessation
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| FD9A | Lapse of provisional protection due to non-payment of fees |