HUP0302465A2 - Javított eljárás eletriptan előállítására és ezt tartalmazó gyógyszerkészítmény - Google Patents
Javított eljárás eletriptan előállítására és ezt tartalmazó gyógyszerkészítményInfo
- Publication number
- HUP0302465A2 HUP0302465A2 HU0302465A HUP0302465A HUP0302465A2 HU P0302465 A2 HUP0302465 A2 HU P0302465A2 HU 0302465 A HU0302465 A HU 0302465A HU P0302465 A HUP0302465 A HU P0302465A HU P0302465 A2 HUP0302465 A2 HU P0302465A2
- Authority
- HU
- Hungary
- Prior art keywords
- eletriptan
- improved process
- preparation
- pharmaceutical composition
- composition containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 title abstract 3
- 229960002472 eletriptan Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A jelen találmány tárgya javított eljárás a migrén elleni, akereskedelemben hidrogén-bromid-só alakjában kapható (R)-5-(2-benzol-szulfonil-etil)-3-N-metil-pirrolidin-2-il-metil-1H-indol(eletriptan)előállítására[(I*HBr) képletű vegyület], továbbá a szóban forgóeljárással kapott, közbenső terméket és dimert nem tartalmazó termék.A találmány kiterjed a javított eljárással előállított eletriptanttartalmazó gyógyszerkészítményre is . Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031094.6A GB0031094D0 (en) | 2000-12-20 | 2000-12-20 | New Process |
| PCT/IB2001/002338 WO2002050063A1 (en) | 2000-12-20 | 2001-12-06 | New process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0302465A2 true HUP0302465A2 (hu) | 2003-12-29 |
Family
ID=9905487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302465A HUP0302465A2 (hu) | 2000-12-20 | 2001-12-06 | Javított eljárás eletriptan előállítására és ezt tartalmazó gyógyszerkészítmény |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1373254B1 (hu) |
| JP (1) | JP2004516290A (hu) |
| KR (1) | KR20030061448A (hu) |
| CN (1) | CN1199969C (hu) |
| AR (2) | AR035406A1 (hu) |
| AT (1) | ATE308539T1 (hu) |
| AU (1) | AU2002218440A1 (hu) |
| BR (1) | BR0116324A (hu) |
| CA (1) | CA2432138C (hu) |
| CZ (1) | CZ20031640A3 (hu) |
| DE (1) | DE60114668T2 (hu) |
| ES (1) | ES2249386T3 (hu) |
| GB (1) | GB0031094D0 (hu) |
| HU (1) | HUP0302465A2 (hu) |
| IL (1) | IL155706A0 (hu) |
| MX (1) | MXPA03005569A (hu) |
| PL (1) | PL362716A1 (hu) |
| RU (1) | RU2256660C2 (hu) |
| WO (1) | WO2002050063A1 (hu) |
| ZA (1) | ZA200303446B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927296B2 (en) | 2003-07-23 | 2005-08-09 | Pfizer Inc. | Process |
| EP2093225A1 (en) * | 2007-05-01 | 2009-08-26 | Plus Chemicals B.V. | Process for preparing crystalline eletriptan hydrobromide form ß |
| IT1393700B1 (it) * | 2009-04-22 | 2012-05-08 | F S I Fabbrica Italiana Sint | Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo |
| WO2011024039A1 (en) * | 2009-08-25 | 2011-03-03 | Ramesh Babu Potluri | Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives |
| WO2011089614A1 (en) | 2010-01-19 | 2011-07-28 | Sms Pharmaceuticals Limited | PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM |
| WO2012004811A1 (en) * | 2010-07-06 | 2012-01-12 | Ind-Swift Laboratories Limited | Process for the preparation of 5-substsituted indole derivative |
| JP2019502761A (ja) | 2016-01-21 | 2019-01-31 | ラボラトリオス レヴィ エセエレ | （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法 |
| CN112440631B (zh) * | 2020-11-02 | 2022-09-13 | 长城汽车股份有限公司 | 一种调节胎压装置、方法、系统以及车辆 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2095360C1 (ru) * | 1990-10-15 | 1997-11-10 | Пфайзер Инк. | Производные индола, их оптические изомеры и фармацевтически приемлемые соли |
-
2000
- 2000-12-20 GB GBGB0031094.6A patent/GB0031094D0/en not_active Ceased
-
2001
- 2001-12-06 HU HU0302465A patent/HUP0302465A2/hu unknown
- 2001-12-06 ES ES01271106T patent/ES2249386T3/es not_active Expired - Lifetime
- 2001-12-06 CZ CZ20031640A patent/CZ20031640A3/cs unknown
- 2001-12-06 JP JP2002551559A patent/JP2004516290A/ja active Pending
- 2001-12-06 AU AU2002218440A patent/AU2002218440A1/en not_active Abandoned
- 2001-12-06 AT AT01271106T patent/ATE308539T1/de not_active IP Right Cessation
- 2001-12-06 RU RU2003118330/04A patent/RU2256660C2/ru not_active IP Right Cessation
- 2001-12-06 BR BR0116324-8A patent/BR0116324A/pt not_active IP Right Cessation
- 2001-12-06 IL IL15570601A patent/IL155706A0/xx unknown
- 2001-12-06 MX MXPA03005569A patent/MXPA03005569A/es active IP Right Grant
- 2001-12-06 CA CA002432138A patent/CA2432138C/en not_active Expired - Fee Related
- 2001-12-06 PL PL01362716A patent/PL362716A1/xx not_active Application Discontinuation
- 2001-12-06 DE DE60114668T patent/DE60114668T2/de not_active Expired - Fee Related
- 2001-12-06 KR KR10-2003-7008081A patent/KR20030061448A/ko not_active Application Discontinuation
- 2001-12-06 EP EP01271106A patent/EP1373254B1/en not_active Expired - Lifetime
- 2001-12-06 WO PCT/IB2001/002338 patent/WO2002050063A1/en active IP Right Grant
- 2001-12-06 CN CNB018199674A patent/CN1199969C/zh not_active Expired - Fee Related
- 2001-12-18 AR ARP010105858A patent/AR035406A1/es unknown
-
2003
- 2003-05-06 ZA ZA200303446A patent/ZA200303446B/en unknown
-
2004
- 2004-02-03 AR ARP040100334A patent/AR043016A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1373254B1 (en) | 2005-11-02 |
| ES2249386T3 (es) | 2006-04-01 |
| AR035406A1 (es) | 2004-05-26 |
| ATE308539T1 (de) | 2005-11-15 |
| AU2002218440A1 (en) | 2002-07-01 |
| GB0031094D0 (en) | 2001-01-31 |
| MXPA03005569A (es) | 2003-10-06 |
| WO2002050063A1 (en) | 2002-06-27 |
| PL362716A1 (en) | 2004-11-02 |
| CZ20031640A3 (cs) | 2004-08-18 |
| ZA200303446B (en) | 2004-07-05 |
| BR0116324A (pt) | 2003-10-14 |
| CN1487932A (zh) | 2004-04-07 |
| CA2432138A1 (en) | 2002-06-27 |
| DE60114668D1 (de) | 2005-12-08 |
| DE60114668T2 (de) | 2006-07-20 |
| JP2004516290A (ja) | 2004-06-03 |
| CA2432138C (en) | 2007-05-08 |
| RU2256660C2 (ru) | 2005-07-20 |
| IL155706A0 (en) | 2004-02-19 |
| CN1199969C (zh) | 2005-05-04 |
| KR20030061448A (ko) | 2003-07-18 |
| AR043016A2 (es) | 2005-07-13 |
| EP1373254A1 (en) | 2004-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |