HUP0301608A2 - Klórozott pirimidinek szintézise - Google Patents
Klórozott pirimidinek szintéziseInfo
- Publication number
- HUP0301608A2 HUP0301608A2 HU0301608A HUP0301608A HUP0301608A2 HU P0301608 A2 HUP0301608 A2 HU P0301608A2 HU 0301608 A HU0301608 A HU 0301608A HU P0301608 A HUP0301608 A HU P0301608A HU P0301608 A2 HUP0301608 A2 HU P0301608A2
- Authority
- HU
- Hungary
- Prior art keywords
- synthesis
- formula
- compound
- hydroxypyrimidine
- chloro
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- XJPZKYIHCLDXST-UHFFFAOYSA-N 4,6-dichloropyrimidine Chemical compound ClC1=CC(Cl)=NC=N1 XJPZKYIHCLDXST-UHFFFAOYSA-N 0.000 abstract 1
- -1 5-substituted-4,6-dichloropyrimidine compounds Chemical class 0.000 abstract 1
- AXFABVAPHSWFMD-UHFFFAOYSA-N 6-chloro-1h-pyrimidin-4-one Chemical compound OC1=CC(Cl)=NC=N1 AXFABVAPHSWFMD-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya eljárás 4,6-diklór-pirimidin, 5-szubsztituált-4,6-diklór-pitimidin-vegyületek, 4-klór-6-hidroxi-pirimidin és 5-szubsztituált-4-klór-6-hidroxi-pirimidin-vegyületek előállítására olymódon, hogy egy első imidoil-klorid-vegyületet, éspedig (V) képletűformamidoil-kloridot és egy második imidoil-klorid-vegyületet, éspedigegy (VI) általános képletű, két alfa-helyzetű hidrogénatomottartalmazó vegyületet - a képletben R1 hidrogénatomot vagy 1-12szénatomos szénhidrogéncsoportot jelent - foszgénnel reagáltatnak. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21688200P | 2000-07-07 | 2000-07-07 | |
PCT/GB2001/002614 WO2002004428A2 (en) | 2000-07-07 | 2001-06-13 | Synthesis of chlorinated pyrimidines |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0301608A2 true HUP0301608A2 (hu) | 2003-08-28 |
HUP0301608A3 HUP0301608A3 (en) | 2005-01-28 |
HU228228B1 HU228228B1 (en) | 2013-02-28 |
Family
ID=22808846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301608A HU228228B1 (en) | 2000-07-07 | 2001-06-13 | Synthesis of chlorinated pyrimidines |
Country Status (15)
Country | Link |
---|---|
US (1) | US6608199B2 (hu) |
EP (1) | EP1301489B1 (hu) |
JP (1) | JP5032732B2 (hu) |
KR (1) | KR100829148B1 (hu) |
CN (1) | CN1301976C (hu) |
AR (1) | AR030238A1 (hu) |
AT (1) | ATE431821T1 (hu) |
AU (1) | AU2001264114A1 (hu) |
BR (1) | BRPI0112222B8 (hu) |
DE (1) | DE60138758D1 (hu) |
ES (1) | ES2323756T3 (hu) |
HU (1) | HU228228B1 (hu) |
IL (2) | IL153365A0 (hu) |
TW (1) | TWI287006B (hu) |
WO (1) | WO2002004428A2 (hu) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19929353A1 (de) * | 1999-06-26 | 2000-12-28 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin |
CN106053691A (zh) * | 2016-07-19 | 2016-10-26 | 安徽广信农化股份有限公司 | 一种测定4,6‑二氯嘧啶含量的方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4353830A (en) * | 1979-12-26 | 1982-10-12 | General Electric Company | Process for the preparation of substituted amidines |
DE3431698A1 (de) | 1984-08-29 | 1986-03-13 | Bayer Ag, 5090 Leverkusen | 5,5-dichlor-4,5-dihydro-6-hydroxy-2-trichlormethyl-pyrimidin-4-on, ein verfahren zu seiner herstellung und seine verwendung |
US5145856A (en) | 1989-02-10 | 1992-09-08 | Imperial Chemical Industries Plc | Fungicides |
GB9122430D0 (en) | 1990-11-16 | 1991-12-04 | Ici Plc | Chemical process |
SK279618B6 (sk) * | 1992-01-22 | 1999-01-11 | Lonza A.G. (Dir.:Basel) | N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s |
DE4408404A1 (de) | 1994-03-12 | 1995-09-14 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Chlorpyrimidinen |
GB9408270D0 (en) | 1994-04-26 | 1994-06-15 | Zeneca Ltd | Chemical process |
CA2145928C (en) | 1994-04-27 | 2007-10-09 | Gerhard Stucky | N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation |
US6018045A (en) | 1995-01-30 | 2000-01-25 | Zeneca Limited | Process for preparing 4,6-dichloro-pyrimidine |
AT402818B (de) | 1995-06-02 | 1997-09-25 | Chemie Linz Gmbh | Verfahren zur herstellung von reinem 4,6-dichlorpyrimidin |
DE19531299A1 (de) | 1995-08-25 | 1997-02-27 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidinen |
GB9610320D0 (en) | 1996-05-17 | 1996-07-24 | Zeneca Ltd | Chemical process |
US6160117A (en) | 1997-11-06 | 2000-12-12 | Zeneca Limited | Chemical process |
-
2001
- 2001-06-08 US US09/876,964 patent/US6608199B2/en not_active Expired - Lifetime
- 2001-06-13 DE DE60138758T patent/DE60138758D1/de not_active Expired - Lifetime
- 2001-06-13 CN CNB01812416XA patent/CN1301976C/zh not_active Expired - Lifetime
- 2001-06-13 AT AT01938436T patent/ATE431821T1/de not_active IP Right Cessation
- 2001-06-13 BR BRPI0112222A patent/BRPI0112222B8/pt active IP Right Grant
- 2001-06-13 IL IL15336501A patent/IL153365A0/xx active IP Right Grant
- 2001-06-13 WO PCT/GB2001/002614 patent/WO2002004428A2/en active Application Filing
- 2001-06-13 HU HU0301608A patent/HU228228B1/hu unknown
- 2001-06-13 JP JP2002509295A patent/JP5032732B2/ja not_active Expired - Lifetime
- 2001-06-13 KR KR1020037000146A patent/KR100829148B1/ko active IP Right Grant
- 2001-06-13 ES ES01938436T patent/ES2323756T3/es not_active Expired - Lifetime
- 2001-06-13 EP EP01938436A patent/EP1301489B1/en not_active Expired - Lifetime
- 2001-06-13 AU AU2001264114A patent/AU2001264114A1/en not_active Abandoned
- 2001-06-25 AR ARP010103016A patent/AR030238A1/es active IP Right Grant
- 2001-06-28 TW TW090115678A patent/TWI287006B/zh not_active IP Right Cessation
-
2002
- 2002-12-09 IL IL153365A patent/IL153365A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR100829148B1 (ko) | 2008-05-13 |
CN1301976C (zh) | 2007-02-28 |
ES2323756T3 (es) | 2009-07-24 |
IL153365A (en) | 2007-09-20 |
EP1301489A2 (en) | 2003-04-16 |
BRPI0112222B1 (pt) | 2015-09-01 |
WO2002004428A3 (en) | 2002-04-18 |
HUP0301608A3 (en) | 2005-01-28 |
JP2004505020A (ja) | 2004-02-19 |
BRPI0112222B8 (pt) | 2016-05-31 |
AR030238A1 (es) | 2003-08-13 |
EP1301489B1 (en) | 2009-05-20 |
BR0112222A (pt) | 2003-05-06 |
AU2001264114A1 (en) | 2002-01-21 |
US6608199B2 (en) | 2003-08-19 |
CN1449389A (zh) | 2003-10-15 |
ATE431821T1 (de) | 2009-06-15 |
US20020055633A1 (en) | 2002-05-09 |
IL153365A0 (en) | 2003-07-06 |
DE60138758D1 (de) | 2009-07-02 |
JP5032732B2 (ja) | 2012-09-26 |
KR20030020911A (ko) | 2003-03-10 |
WO2002004428A2 (en) | 2002-01-17 |
HU228228B1 (en) | 2013-02-28 |
TWI287006B (en) | 2007-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): DR. JALSOVSZKY GYOERGYNE UEGYVED, HU Representative=s name: DR. MISKOLCI MARIA UEGYVED, HU |