HUP0301348A2 - COX-2 inhibitorokat tartalmazó fájdalomcsillapító és gyulladásgátló hatású készítmények és alkalmazásuk - Google Patents

COX-2 inhibitorokat tartalmazó fájdalomcsillapító és gyulladásgátló hatású készítmények és alkalmazásuk

Info

Publication number
HUP0301348A2
HUP0301348A2 HU0301348A HUP0301348A HUP0301348A2 HU P0301348 A2 HUP0301348 A2 HU P0301348A2 HU 0301348 A HU0301348 A HU 0301348A HU P0301348 A HUP0301348 A HU P0301348A HU P0301348 A2 HUP0301348 A2 HU P0301348A2
Authority
HU
Hungary
Prior art keywords
analgesic
inhibitors
compositions containing
inflammatory compositions
containing gox
Prior art date
Application number
HU0301348A
Other languages
English (en)
Inventor
Stephen Allen Cooper
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of HUP0301348A2 publication Critical patent/HUP0301348A2/hu
Publication of HUP0301348A3 publication Critical patent/HUP0301348A3/hu
Publication of HU229440B1 publication Critical patent/HU229440B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány fájdalomcsillapító hatású készítményre vonatkozik, amelylényegében egy ciklooxigenáz-2 inhibitort és egy másik vegyületet,mégpedig egy nemszteroid típusú gyulladásgátló szert, acetaminofentvagy ezek keverékét tartalmazza. A találmány kiterjed a fentikészítmény érzéstelenítésre történő alkalmazására. Ó
HU0301348A 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions containing gox-2 inhibitors HU229440B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21130700P 2000-06-13 2000-06-13
PCT/US2001/018990 WO2001095898A1 (en) 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions containing cox-2 inhibitors

Publications (3)

Publication Number Publication Date
HUP0301348A2 true HUP0301348A2 (hu) 2003-08-28
HUP0301348A3 HUP0301348A3 (en) 2005-05-30
HU229440B1 HU229440B1 (en) 2013-12-30

Family

ID=22786362

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301348A HU229440B1 (en) 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions containing gox-2 inhibitors

Country Status (23)

Country Link
US (2) US6924303B2 (hu)
EP (1) EP1296665B1 (hu)
JP (1) JP5579958B2 (hu)
KR (1) KR20030019422A (hu)
CN (1) CN100588395C (hu)
AT (1) ATE511844T1 (hu)
AU (2) AU2001268377B2 (hu)
BR (1) BR0111767A (hu)
CA (1) CA2411960C (hu)
DK (1) DK1296665T3 (hu)
EA (2) EA011309B1 (hu)
ES (1) ES2365387T3 (hu)
HK (1) HK1059378A1 (hu)
HU (1) HU229440B1 (hu)
IL (2) IL153303A0 (hu)
MX (1) MXPA02012344A (hu)
NO (1) NO331092B1 (hu)
NZ (1) NZ522957A (hu)
PL (1) PL206268B1 (hu)
PT (1) PT1296665E (hu)
RU (1) RU2003100874A (hu)
WO (1) WO2001095898A1 (hu)
ZA (1) ZA200209944B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011309B1 (ru) * 2000-06-13 2009-02-27 Вайет Составы для ослабления боли, содержащие целекоксиб
ATE524186T1 (de) * 2002-02-19 2011-09-15 Adcock Ingram Ltd Pharmazeutische kombinationen bestehend aus meloxicam, tramadol und paracetamol
EP1587506B1 (en) * 2002-12-18 2008-07-23 Algorx Administration of capsaicinoids
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
US20060281775A1 (en) 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
MX2009004203A (es) 2006-10-20 2009-07-02 Mcneil Ppc Inc Combinaciones de paracetamol/ibuprofeno y metodo para su uso.
TR200904862A1 (tr) * 2009-05-29 2010-12-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Sukraloz formülasyonu ve üretim prosesi
CN109496151A (zh) * 2016-05-27 2019-03-19 雷迪博士实验室有限公司 用于治疗疼痛的塞来昔布口服组合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331000A (en) * 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
RO118291B1 (ro) * 1993-11-30 2003-04-30 Searle & Co Derivati de pirazol 1,3,4,5 - tetrasubstituiti si compozitie farmaceutica care ii contine
CZ291463B6 (cs) 1996-05-17 2003-03-12 Merck And Co., Inc. Farmaceutický prostředek
CA2412968C (en) 1996-07-18 2010-05-11 Merck Frosst Canada & Co. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
RU2182016C2 (ru) * 1997-03-20 2002-05-10 Панацея Биотек Лтд. Спазмолитическая композиция, способ получения спазмолитической композиции
EP0868915A1 (en) 1997-04-02 1998-10-07 Panacea Biotec Limited An anti-spasmodic and antiinflammatory composition containing a NSAID, pentifenone and fenpiverinium
DZ2479A1 (fr) 1997-05-05 2003-02-01 Pfizer Composés inhibiteurs sélectifs de cox-2 anti-inflammatoires et compositions pharmaceutiques les contenant.
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
EP1109799B1 (en) 1999-04-14 2003-12-17 Pacific Corporation 4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2 inhibitors
US6524623B1 (en) * 1999-11-12 2003-02-25 Milton Hodosh Therapeutic compositions and methods of use thereof
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EA011309B1 (ru) 2000-06-13 2009-02-27 Вайет Составы для ослабления боли, содержащие целекоксиб

Also Published As

Publication number Publication date
DK1296665T3 (da) 2011-07-18
NO331092B1 (no) 2011-10-03
CA2411960C (en) 2010-10-12
EA200802070A1 (ru) 2009-06-30
EP1296665B1 (en) 2011-06-08
CN100588395C (zh) 2010-02-10
CN1443067A (zh) 2003-09-17
US20030216461A1 (en) 2003-11-20
EA200300692A1 (ru) 2003-12-25
IL153303A (en) 2010-11-30
PL360469A1 (en) 2004-09-06
EA011309B1 (ru) 2009-02-27
NO20025983D0 (no) 2002-12-12
NO20025983L (no) 2003-02-10
EP1296665A1 (en) 2003-04-02
BR0111767A (pt) 2003-07-08
AU6837701A (en) 2001-12-24
ZA200209944B (en) 2003-10-08
JP5579958B2 (ja) 2014-08-27
WO2001095898A1 (en) 2001-12-20
IL153303A0 (en) 2003-07-06
KR20030019422A (ko) 2003-03-06
EP1296665A4 (en) 2005-07-27
CA2411960A1 (en) 2001-12-20
HK1059378A1 (en) 2004-07-02
PT1296665E (pt) 2011-07-05
US20050090538A1 (en) 2005-04-28
US7754753B2 (en) 2010-07-13
ES2365387T3 (es) 2011-10-03
NZ522957A (en) 2004-03-26
ATE511844T1 (de) 2011-06-15
US6924303B2 (en) 2005-08-02
PL206268B1 (pl) 2010-07-30
AU2001268377B2 (en) 2005-07-07
HU229440B1 (en) 2013-12-30
HUP0301348A3 (en) 2005-05-30
RU2003100874A (ru) 2004-06-27
JP2004503497A (ja) 2004-02-05
MXPA02012344A (es) 2004-02-26

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