HUP0301306A2 - Gyűrűs ketonok, eljárás azok előállítására és alkalmazásuk aminosavak szintézisében - Google Patents

Gyűrűs ketonok, eljárás azok előállítására és alkalmazásuk aminosavak szintézisében

Info

Publication number
HUP0301306A2
HUP0301306A2 HU0301306A HUP0301306A HUP0301306A2 HU P0301306 A2 HUP0301306 A2 HU P0301306A2 HU 0301306 A HU0301306 A HU 0301306A HU P0301306 A HUP0301306 A HU P0301306A HU P0301306 A2 HUP0301306 A2 HU P0301306A2
Authority
HU
Hungary
Prior art keywords
general formula
formula
addition
compound
product
Prior art date
Application number
HU0301306A
Other languages
English (en)
Inventor
David Clive Blakemore
Justin Stephen Bryans
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HUP0301306A2 publication Critical patent/HUP0301306A2/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya eljárás enantiomer-tisztaságú (I) vagy (II)általános képletű vegyületek előállítására, amely szerint egy olyanszerves fémvegyület nukleofil-reagens - amely a fent meghatározott Rcsoportot biztosítja - konjugált addícióját hajtják végre a (III) vagy(IV) általános képletű vegyülethez, így a (V) vagy (VI) általánosképletű termék transz-3,4-diszubsztituált addícióját hajtják végre, azX kilépő csoportot a (V) vagy (VI) általános képletű addícióstermékből eliminálják, így a (VII) vagy (VIII) általános képletű (R)-vagy (S)-4-alkil- vagy -4-alkenil-ciklopent-2-én-1-ont kapják, és/vagya (VII) vagy (VIII) általános képletű vegyületet hidrogénezik, így egy(I) általános képletű ciklopentanont kapnak, vagy egy második olyanszerves fémvegyület nukleofil-reagens konjugált addícióját hajtjákvégre a (VII) vagy (VIII) általános képletű vegyülethez, amely a fentmeghatározott R' csoportot biztosítja, így a (II) általános képletűtransz-3,4diszubsztituált addíciós terméket kapják. A találmánytárgyát képezik továbbá új (II) általános képletű vegyületek. Ó
HU0301306A 2000-06-28 2001-06-28 Gyűrűs ketonok, eljárás azok előállítására és alkalmazásuk aminosavak szintézisében HUP0301306A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0015771A GB2364049A (en) 2000-06-28 2000-06-28 Cyclic ketones and their use in the synthesis of amino acids
PCT/GB2001/002900 WO2002000584A1 (en) 2000-06-28 2001-06-28 Cyclic ketones, their preparation and their use in the synthesis of amino acids

Publications (1)

Publication Number Publication Date
HUP0301306A2 true HUP0301306A2 (hu) 2003-08-28

Family

ID=9894534

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301306A HUP0301306A2 (hu) 2000-06-28 2001-06-28 Gyűrűs ketonok, eljárás azok előállítására és alkalmazásuk aminosavak szintézisében

Country Status (24)

Country Link
US (2) US6872856B2 (hu)
EP (1) EP1296921A1 (hu)
JP (1) JP2004501884A (hu)
KR (1) KR100778953B1 (hu)
CN (1) CN1438985A (hu)
AP (1) AP2002002699A0 (hu)
AU (2) AU2001266208B2 (hu)
BR (1) BR0112076A (hu)
CA (1) CA2411808A1 (hu)
EA (1) EA200201202A1 (hu)
GB (1) GB2364049A (hu)
HR (1) HRP20021017A2 (hu)
HU (1) HUP0301306A2 (hu)
IL (2) IL153704A0 (hu)
IS (1) IS6636A (hu)
MA (1) MA26921A1 (hu)
MX (1) MXPA03000076A (hu)
NO (1) NO20026198D0 (hu)
NZ (1) NZ523218A (hu)
OA (1) OA12298A (hu)
PL (1) PL359107A1 (hu)
WO (1) WO2002000584A1 (hu)
YU (1) YU93702A (hu)
ZA (1) ZA200300243B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2364049A (en) * 2000-06-28 2002-01-16 Warner Lambert Co Cyclic ketones and their use in the synthesis of amino acids
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2615490A1 (en) * 2005-07-18 2007-01-25 Pharmacia & Upjohn Company Llc Stereoselective synthesis of 3,4-disubstituted cyclopentanones and related compounds
CN102190536A (zh) * 2010-03-08 2011-09-21 华东理工大学 一种有机催化烯酮与有机膦化合物不对称共轭加成的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5254708A (en) * 1987-06-16 1993-10-19 Nissan Chemical Industries, Ltd. Substituted cyclic ketones, substituted cyclic enones, and process for producing the same
US5134238A (en) * 1990-05-24 1992-07-28 Brigham Young University Chiral copper amine complexes
US5480962A (en) 1993-07-22 1996-01-02 Eastman Chemical Company Copolyesters having repeat units derived from succinic acid
CN1303059C (zh) * 1997-10-27 2007-03-07 沃尼尔·朗伯公司 作为药物的环状氨基酸及其衍生物
GB2364049A (en) * 2000-06-28 2002-01-16 Warner Lambert Co Cyclic ketones and their use in the synthesis of amino acids

Also Published As

Publication number Publication date
KR100778953B1 (ko) 2007-11-27
BR0112076A (pt) 2003-09-02
NO20026198L (no) 2002-12-23
NO20026198D0 (no) 2002-12-23
NZ523218A (en) 2004-06-25
AU6620801A (en) 2002-01-08
OA12298A (en) 2004-03-18
IL190490A0 (en) 2008-11-03
AU2001266208B2 (en) 2006-11-23
PL359107A1 (en) 2004-08-23
KR20030016311A (ko) 2003-02-26
GB0015771D0 (en) 2000-08-16
US20050215816A1 (en) 2005-09-29
CN1438985A (zh) 2003-08-27
HRP20021017A2 (en) 2004-02-29
JP2004501884A (ja) 2004-01-22
EA200201202A1 (ru) 2003-06-26
ZA200300243B (en) 2004-06-14
AP2002002699A0 (en) 2002-12-31
WO2002000584A1 (en) 2002-01-03
CA2411808A1 (en) 2002-01-03
MA26921A1 (fr) 2004-12-20
MXPA03000076A (es) 2003-10-15
IS6636A (is) 2002-11-28
IL153704A0 (en) 2003-07-06
US20030187296A1 (en) 2003-10-02
US6872856B2 (en) 2005-03-29
YU93702A (sh) 2006-08-17
GB2364049A (en) 2002-01-16
EP1296921A1 (en) 2003-04-02

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees