HUP0301207A2 - Új eljárás pirazolo-pirimidinonok előállítására - Google Patents
Új eljárás pirazolo-pirimidinonok előállításáraInfo
- Publication number
- HUP0301207A2 HUP0301207A2 HU0301207A HUP0301207A HUP0301207A2 HU P0301207 A2 HUP0301207 A2 HU P0301207A2 HU 0301207 A HU0301207 A HU 0301207A HU P0301207 A HUP0301207 A HU P0301207A HU P0301207 A2 HUP0301207 A2 HU P0301207A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl group
- short
- atom
- het
- chain alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical class N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 pyrazolopyrimidinone compound Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000005418 aryl aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgya eljárás (I) általános képletű pirazolopirimidinonokúj előállítására. Az (I) általános képletben: A jelentése CH vagy N;R1 jelentése hidrogénatom vagy adott esetben oxigénatommalmegszakított rövid szénláncú alkilcsoport, Het, alkil-Het, aril- vagyalkil-aril-csoport, ahol az utóbbi 5 csoportban az összes csoportadott esetben szubsztituált, és/vagy a rövid szénláncú alkilcsoportesetében adott esetben a végén szubsztituált egy vagy többszubsztituenssel, mégpedig halogénatommal, ciano-, nitro-, rövidszénláncú alkilcsoporttal, OR5, C(O)R6, C(O)OR7, C(O)NR8R9, NR10aR10bvagy SO2NR11aR11b csoporttal; R2 és R4 jelentése egymástól függetlenülrövid szénláncú alkilcsoport; R3 jelentése adott esetben oxigénatommalmegszakított, rövid szénláncú alkilcsoport; Het jelentése adottesetben szubsztituált, 4-12-tagú, heterociklusos csoport, amely egyvagy több nitrogén-, oxigén- és/vagy kénatomot tartalmazheteroatomként; R5, R6, R7, R8, R9, R11a és R11b jelentése egymástólfüggetlenül hidrogénatom vagy rövid szénláncú alkilcsoport; R10a ésR10b jelentése egymástól függetlenül hidrogénatom vagy rövid szénláncúalkilcsoport, vagy a nitrogénatommal együtt, melyhez kapcsolódnak,azetidinil-, pirrolidinil- vagy piperidinilgyűrűt képeznek. Az eljárásszerint egy (II) általános képletű vegyületet dehidrogéneznek. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0015462A GB0015462D0 (en) | 2000-06-22 | 2000-06-22 | Novel process for the preparation of pyrazolopyrimidinones |
| GB0105878A GB0105878D0 (en) | 2001-03-09 | 2001-03-09 | Novel process for the preparation of pyrazoloprimidinones |
| PCT/IB2001/001038 WO2001098303A1 (en) | 2000-06-22 | 2001-06-07 | Novel process for the preparation of pyrazolopyrimidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0301207A2 true HUP0301207A2 (hu) | 2003-08-28 |
| HUP0301207A3 HUP0301207A3 (en) | 2006-02-28 |
Family
ID=26244537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301207A HUP0301207A3 (en) | 2000-06-22 | 2001-06-07 | Novel process for the preparation of pyrazolopyrimidinones |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1296983B1 (hu) |
| JP (1) | JP2004501154A (hu) |
| KR (1) | KR100525699B1 (hu) |
| AP (1) | AP2001002195A0 (hu) |
| AR (1) | AR028729A1 (hu) |
| AT (1) | ATE282619T1 (hu) |
| AU (2) | AU2001262592B2 (hu) |
| BR (1) | BR0111864A (hu) |
| CA (1) | CA2411957C (hu) |
| CZ (1) | CZ20024130A3 (hu) |
| DE (1) | DE60107248T2 (hu) |
| ES (1) | ES2231498T3 (hu) |
| GT (2) | GT200100113A (hu) |
| HK (1) | HK1079198A1 (hu) |
| HU (1) | HUP0301207A3 (hu) |
| IL (1) | IL152983A0 (hu) |
| MX (1) | MXPA02012887A (hu) |
| MY (1) | MY127737A (hu) |
| PA (1) | PA8520001A1 (hu) |
| PE (1) | PE20020091A1 (hu) |
| PL (1) | PL360299A1 (hu) |
| PT (1) | PT1296983E (hu) |
| SV (1) | SV2002000502A (hu) |
| TN (1) | TNSN01092A1 (hu) |
| WO (1) | WO2001098303A1 (hu) |
| YU (1) | YU84702A (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310144B1 (es) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5. |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| CA2347950C (en) * | 1998-10-23 | 2005-05-03 | Pfizer Inc. | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction |
-
2001
- 2001-06-07 HU HU0301207A patent/HUP0301207A3/hu unknown
- 2001-06-07 AP APAP/P/2001/002195A patent/AP2001002195A0/en unknown
- 2001-06-07 CZ CZ20024130A patent/CZ20024130A3/cs unknown
- 2001-06-07 DE DE60107248T patent/DE60107248T2/de not_active Expired - Fee Related
- 2001-06-07 ES ES01936729T patent/ES2231498T3/es not_active Expired - Lifetime
- 2001-06-07 BR BR0111864-1A patent/BR0111864A/pt not_active IP Right Cessation
- 2001-06-07 CA CA002411957A patent/CA2411957C/en not_active Expired - Fee Related
- 2001-06-07 EP EP01936729A patent/EP1296983B1/en not_active Expired - Lifetime
- 2001-06-07 IL IL15298301A patent/IL152983A0/xx unknown
- 2001-06-07 AU AU2001262592A patent/AU2001262592B2/en not_active Ceased
- 2001-06-07 PT PT01936729T patent/PT1296983E/pt unknown
- 2001-06-07 AT AT01936729T patent/ATE282619T1/de not_active IP Right Cessation
- 2001-06-07 KR KR10-2002-7017475A patent/KR100525699B1/ko not_active IP Right Cessation
- 2001-06-07 YU YU84702A patent/YU84702A/sh unknown
- 2001-06-07 AU AU6259201A patent/AU6259201A/xx active Pending
- 2001-06-07 MX MXPA02012887A patent/MXPA02012887A/es active IP Right Grant
- 2001-06-07 PL PL36029901A patent/PL360299A1/xx not_active Application Discontinuation
- 2001-06-07 JP JP2002504259A patent/JP2004501154A/ja not_active Ceased
- 2001-06-07 WO PCT/IB2001/001038 patent/WO2001098303A1/en not_active Application Discontinuation
- 2001-06-14 GT GT200100113A patent/GT200100113A/es unknown
- 2001-06-14 GT GT200100113AK patent/GT200100113AA/es unknown
- 2001-06-15 AR ARP010102878A patent/AR028729A1/es unknown
- 2001-06-18 PE PE2001000586A patent/PE20020091A1/es not_active Application Discontinuation
- 2001-06-19 PA PA20018520001A patent/PA8520001A1/es unknown
- 2001-06-19 MY MYPI20012890A patent/MY127737A/en unknown
- 2001-06-21 TN TNTNSN01092A patent/TNSN01092A1/fr unknown
- 2001-06-21 SV SV2001000502A patent/SV2002000502A/es not_active Application Discontinuation
-
2005
- 2005-12-06 HK HK05111131A patent/HK1079198A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200100113AA (es) | 2006-04-10 |
| SV2002000502A (es) | 2002-07-03 |
| PA8520001A1 (es) | 2003-09-05 |
| PE20020091A1 (es) | 2002-02-21 |
| MXPA02012887A (es) | 2003-05-14 |
| HK1079198A1 (en) | 2006-03-31 |
| EP1296983B1 (en) | 2004-11-17 |
| TNSN01092A1 (fr) | 2005-11-10 |
| KR100525699B1 (ko) | 2005-11-03 |
| CA2411957A1 (en) | 2001-12-27 |
| DE60107248D1 (de) | 2004-12-23 |
| PL360299A1 (en) | 2004-09-06 |
| ATE282619T1 (de) | 2004-12-15 |
| CA2411957C (en) | 2007-09-18 |
| CZ20024130A3 (cs) | 2004-01-14 |
| EP1296983A1 (en) | 2003-04-02 |
| AU6259201A (en) | 2002-01-02 |
| YU84702A (sh) | 2005-09-19 |
| DE60107248T2 (de) | 2005-12-01 |
| HUP0301207A3 (en) | 2006-02-28 |
| MY127737A (en) | 2006-12-29 |
| ES2231498T3 (es) | 2005-05-16 |
| AU2001262592B2 (en) | 2006-07-06 |
| WO2001098303A1 (en) | 2001-12-27 |
| AP2001002195A0 (en) | 2002-12-21 |
| KR20030017556A (ko) | 2003-03-03 |
| BR0111864A (pt) | 2003-07-01 |
| GT200100113A (es) | 2002-06-04 |
| JP2004501154A (ja) | 2004-01-15 |
| PT1296983E (pt) | 2005-02-28 |
| AR028729A1 (es) | 2003-05-21 |
| IL152983A0 (en) | 2003-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |