PE20020091A1 - Nuevo procedimiento para la preparacion de pirazolopirimidinonas - Google Patents
Nuevo procedimiento para la preparacion de pirazolopirimidinonasInfo
- Publication number
- PE20020091A1 PE20020091A1 PE2001000586A PE2001000586A PE20020091A1 PE 20020091 A1 PE20020091 A1 PE 20020091A1 PE 2001000586 A PE2001000586 A PE 2001000586A PE 2001000586 A PE2001000586 A PE 2001000586A PE 20020091 A1 PE20020091 A1 PE 20020091A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- ona
- preparation
- het
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA I DONDE A ES CH, N; R1 ES H, ALQUILO, HET, ALQUIL-HET, ARILO, ARALQUILO CON UNO O MAS SUSTITUYENTES HALO, CIANO, NITRO, OR5, C(O)R6, C(O)OR7, C(O)NR8R9, NR10aR10b, SO2NR11aR11b, ENTRE OTROS; R2 Y R4 SON ALQUILO; R3 ES ALQUILO CON O; HET ES UN GRUPO HETEROCICLO DE 4-12 MIEMBROS CON HETEROATOMOS; R5-R9 Y R11a Y R11b SON H, ALQUILO; R10a Y R10b SON H, ALQUILO Y JUNTO A N FORMAN AZETIDINILO, PIRROLIDINILO, PIPERIDINILO. EL PROCEDIMIENTO COMPRENDE LA DESHIDROGENACION DE UN COMPUESTO DE FORMULA II EN PRESENCIA DE UN AGENTE DE DESHIDROGENACION TAL COMO PALADIO SOBRE CARBONO ( 5% O 10% DE Pd/C), EN PRESENCIA DE UN ACEPTOR DE HIDROGENO TAL COMO CICLOHEXENO O ACIDO MALEICO Y/O UN ACIDO, UNA QUINONA DE ELEVADO POTENCIAL DE OXIDACION, O, MnO2, TRIFENILMETANOL EN ACIDO TRIFLUOROACETICO. LA REACCION SE LLEVA A CABO ENTRE 125°C A 250°C A UNA PRESION DE 13,8 Y 68,9 kPa Y/O UNA ATMOSFERA INERTE. SE REFIERE TAMBIEN AL PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4-ALQUILPIPERAZINILSULFONILFENIL- Y 4-ALQUILPIPERAZINIL-SULFONIL-PIRIDINIL-DIHIDROPIRAZOLO[4,3-d] PIRIMIDIN-7-ONA EN PARTICULAR EL SILDENAFIL (5-[2-ETOXI-5-(4-METILPIPERAZIN-1-ILSULFONIL)FENIL]-1-METIL-3-n-PROPIL-1,6-DIHIDRO-7H-PIRAZOLO[4,3]PIRIMIDIN-7-ONA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0015462A GB0015462D0 (en) | 2000-06-22 | 2000-06-22 | Novel process for the preparation of pyrazolopyrimidinones |
| GB0105878A GB0105878D0 (en) | 2001-03-09 | 2001-03-09 | Novel process for the preparation of pyrazoloprimidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020091A1 true PE20020091A1 (es) | 2002-02-21 |
Family
ID=26244537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000586A PE20020091A1 (es) | 2000-06-22 | 2001-06-18 | Nuevo procedimiento para la preparacion de pirazolopirimidinonas |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1296983B1 (es) |
| JP (1) | JP2004501154A (es) |
| KR (1) | KR100525699B1 (es) |
| AP (1) | AP2001002195A0 (es) |
| AR (1) | AR028729A1 (es) |
| AT (1) | ATE282619T1 (es) |
| AU (2) | AU6259201A (es) |
| BR (1) | BR0111864A (es) |
| CA (1) | CA2411957C (es) |
| CZ (1) | CZ20024130A3 (es) |
| DE (1) | DE60107248T2 (es) |
| ES (1) | ES2231498T3 (es) |
| GT (2) | GT200100113A (es) |
| HK (1) | HK1079198A1 (es) |
| HU (1) | HUP0301207A3 (es) |
| IL (1) | IL152983A0 (es) |
| MX (1) | MXPA02012887A (es) |
| MY (1) | MY127737A (es) |
| PA (1) | PA8520001A1 (es) |
| PE (1) | PE20020091A1 (es) |
| PL (1) | PL360299A1 (es) |
| PT (1) | PT1296983E (es) |
| SV (1) | SV2002000502A (es) |
| TN (1) | TNSN01092A1 (es) |
| WO (1) | WO2001098303A1 (es) |
| YU (1) | YU84702A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310144B1 (es) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5. |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| WO2000024745A1 (en) * | 1998-10-23 | 2000-05-04 | Pfizer Limited | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION |
-
2001
- 2001-06-07 WO PCT/IB2001/001038 patent/WO2001098303A1/en not_active Application Discontinuation
- 2001-06-07 CZ CZ20024130A patent/CZ20024130A3/cs unknown
- 2001-06-07 AU AU6259201A patent/AU6259201A/xx active Pending
- 2001-06-07 PL PL36029901A patent/PL360299A1/xx not_active Application Discontinuation
- 2001-06-07 YU YU84702A patent/YU84702A/sh unknown
- 2001-06-07 ES ES01936729T patent/ES2231498T3/es not_active Expired - Lifetime
- 2001-06-07 PT PT01936729T patent/PT1296983E/pt unknown
- 2001-06-07 AU AU2001262592A patent/AU2001262592B2/en not_active Ceased
- 2001-06-07 AP APAP/P/2001/002195A patent/AP2001002195A0/en unknown
- 2001-06-07 CA CA002411957A patent/CA2411957C/en not_active Expired - Fee Related
- 2001-06-07 DE DE60107248T patent/DE60107248T2/de not_active Expired - Fee Related
- 2001-06-07 KR KR10-2002-7017475A patent/KR100525699B1/ko not_active IP Right Cessation
- 2001-06-07 JP JP2002504259A patent/JP2004501154A/ja not_active Ceased
- 2001-06-07 MX MXPA02012887A patent/MXPA02012887A/es active IP Right Grant
- 2001-06-07 BR BR0111864-1A patent/BR0111864A/pt not_active IP Right Cessation
- 2001-06-07 HU HU0301207A patent/HUP0301207A3/hu unknown
- 2001-06-07 IL IL15298301A patent/IL152983A0/xx unknown
- 2001-06-07 EP EP01936729A patent/EP1296983B1/en not_active Expired - Lifetime
- 2001-06-07 AT AT01936729T patent/ATE282619T1/de not_active IP Right Cessation
- 2001-06-14 GT GT200100113A patent/GT200100113A/es unknown
- 2001-06-14 GT GT200100113AK patent/GT200100113AA/es unknown
- 2001-06-15 AR ARP010102878A patent/AR028729A1/es unknown
- 2001-06-18 PE PE2001000586A patent/PE20020091A1/es not_active Application Discontinuation
- 2001-06-19 PA PA20018520001A patent/PA8520001A1/es unknown
- 2001-06-19 MY MYPI20012890A patent/MY127737A/en unknown
- 2001-06-21 TN TNTNSN01092A patent/TNSN01092A1/fr unknown
- 2001-06-21 SV SV2001000502A patent/SV2002000502A/es not_active Application Discontinuation
-
2005
- 2005-12-06 HK HK05111131A patent/HK1079198A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1079198A1 (en) | 2006-03-31 |
| GT200100113AA (es) | 2006-04-10 |
| CZ20024130A3 (cs) | 2004-01-14 |
| PA8520001A1 (es) | 2003-09-05 |
| HUP0301207A2 (hu) | 2003-08-28 |
| BR0111864A (pt) | 2003-07-01 |
| PL360299A1 (en) | 2004-09-06 |
| JP2004501154A (ja) | 2004-01-15 |
| TNSN01092A1 (fr) | 2005-11-10 |
| ES2231498T3 (es) | 2005-05-16 |
| KR100525699B1 (ko) | 2005-11-03 |
| AP2001002195A0 (en) | 2002-12-21 |
| CA2411957C (en) | 2007-09-18 |
| DE60107248T2 (de) | 2005-12-01 |
| KR20030017556A (ko) | 2003-03-03 |
| AU6259201A (en) | 2002-01-02 |
| PT1296983E (pt) | 2005-02-28 |
| AU2001262592B2 (en) | 2006-07-06 |
| EP1296983B1 (en) | 2004-11-17 |
| CA2411957A1 (en) | 2001-12-27 |
| AR028729A1 (es) | 2003-05-21 |
| IL152983A0 (en) | 2003-06-24 |
| WO2001098303A1 (en) | 2001-12-27 |
| ATE282619T1 (de) | 2004-12-15 |
| MXPA02012887A (es) | 2003-05-14 |
| DE60107248D1 (de) | 2004-12-23 |
| SV2002000502A (es) | 2002-07-03 |
| EP1296983A1 (en) | 2003-04-02 |
| HUP0301207A3 (en) | 2006-02-28 |
| YU84702A (sh) | 2005-09-19 |
| MY127737A (en) | 2006-12-29 |
| GT200100113A (es) | 2002-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |