HUP0301080A2 - Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0301080A2
HUP0301080A2 HU0301080A HUP0301080A HUP0301080A2 HU P0301080 A2 HUP0301080 A2 HU P0301080A2 HU 0301080 A HU0301080 A HU 0301080A HU P0301080 A HUP0301080 A HU P0301080A HU P0301080 A2 HUP0301080 A2 HU P0301080A2
Authority
HU
Hungary
Prior art keywords
group
alkenyl
alkynyl
optionally substituted
tetrahydroquinoline
Prior art date
Application number
HU0301080A
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English (en)
Inventor
Petra Bloms-Funke
Werner Englberger
Matthias Gerlach
Utz-Peter Jagusch
Corinna Maul
Michael Przewosny
Elke Reismüller
Original Assignee
Grünenthal GmbH
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Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of HUP0301080A2 publication Critical patent/HUP0301080A2/hu
Publication of HUP0301080A3 publication Critical patent/HUP0301080A3/hu

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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/34—Tobacco-abuse
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    • A61P25/36—Opioid-abuse
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

A találmány (I) általános képletű helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékokra - mely képletben R1 és R2együtt egy adott esetben szubsztituált, adott esetben oxigén lánctagotis tartalmazó alkilén- vagy alkeniléncsoportot vagy (a), (b), (c),(d), (e) vagy (f) általános képletű csoportot képez; R3 hidrogénatomotvagy adott esetben szubsztituált alkil-, alkenil-, alkinil-,cikloalkil-, heterociklil-, alkil-aril-, alkil-heteroaril-, aril- vagyheteroarilcsoportot jelent; R4 egy R4a vagy ZR4a általános képletűcsoportot jelent, amelyekben Z adott esetben szubsztituált alkil-,alkenil- vagy alkinilcsoportot jelent, és R4a hidrogénatomot, adottesetben szubsztituált alkil-, alkenil-, alkinil-, cikloalkil-,heterociklil-, alkil-aril-, alkil-heteroaril-, aril- vagyheteroarilcsoportot vagy C(O)R9, C(O)OR9, C(S)R9 vagy S(O2)R9csoportot jelent, és R5, R6, R7 és R8 jelentése egymástól függetlenülhidrogén-, fluor-, klór-, bróm- vagy jódatom, vagy ciano-, nitro-,alkil-, alkenil-, alkinil-, OR14, C(O)OR14, OC(S)R14, C(O)R14,C(S)R14, C(S)OR14, SR14, S(O)R14 vagy S(O2)R14 csoport; vagy R5 és R6,R6 és R7 vagy R7 és R8 együtt =CR18-CH=CH-CH= vagy =CH-CRl8=CH-CH=csoportot képez - , e vegyületek előállítására, az e vegyületekettartalmazó gyógyászati készítményekre és e vegyületek gyógyászatihatóanyagként történő felhasználására vonatkozik. Ó
HU0301080A 2000-02-07 2001-01-19 Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives, process for their preparation and pharmaceutical compositions containing them HUP0301080A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10005302A DE10005302A1 (de) 2000-02-07 2000-02-07 Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
PCT/EP2001/000588 WO2001058875A2 (de) 2000-02-07 2001-01-19 Substituierte 1,2,3,4-tetrahydrochinolin-2-carbonsäurederivate

Publications (2)

Publication Number Publication Date
HUP0301080A2 true HUP0301080A2 (hu) 2003-08-28
HUP0301080A3 HUP0301080A3 (en) 2010-04-28

Family

ID=7630076

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Application Number Title Priority Date Filing Date
HU0301080A HUP0301080A3 (en) 2000-02-07 2001-01-19 Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US6699877B2 (hu)
EP (1) EP1254118B1 (hu)
JP (1) JP2003522758A (hu)
AR (1) AR029795A1 (hu)
AT (1) ATE309220T1 (hu)
AU (2) AU2679401A (hu)
CA (1) CA2416343A1 (hu)
CO (1) CO5271673A1 (hu)
DE (2) DE10005302A1 (hu)
DK (1) DK1254118T3 (hu)
ES (1) ES2250345T3 (hu)
HU (1) HUP0301080A3 (hu)
MX (1) MXPA02007661A (hu)
NZ (1) NZ521088A (hu)
PE (1) PE20011079A1 (hu)
WO (1) WO2001058875A2 (hu)

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DE10124953A1 (de) * 2001-05-21 2002-12-12 Marlies Knipper Substanz für die therapeutische Behandlung von Tinnitus
DE10137487A1 (de) * 2001-08-03 2003-03-27 Gruenenthal Gmbh Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10202864A1 (de) 2002-01-24 2003-07-31 Gruenenthal Gmbh Verfahren zur Herstellung von substituierten 1,2.3,4-Tetrahydrochinolin 2-carbonsäuren
JPWO2004013104A1 (ja) * 2002-08-01 2006-09-21 科研製薬株式会社 新規テトラヒドロキノリン誘導体
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
KR20050055747A (ko) 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 ｐｇｄ2 수용체 길항제
DE10304950A1 (de) * 2003-02-06 2004-08-19 Grünenthal GmbH Herstellung von Tetrahydrochinolinbenzofuranen
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
AU2004271932A1 (en) * 2003-08-13 2005-03-24 Oscient Pharmaceuticals Antibiotic cycloalkyltetrahydroquinoline derivatives
FR2864535B1 (fr) * 2003-12-24 2006-12-22 Merck Sante Sas Derives acides de quinoline et leurs applications en therapeutique
MX2007010215A (es) 2005-02-24 2007-11-07 Millennium Pharm Inc Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias.
WO2009073550A2 (en) * 2007-11-30 2009-06-11 Maxthera, Inc. Substituted tetrahydroquinolines as antibacterial agents
MX2012014482A (es) * 2010-06-15 2013-02-21 Gruenenthal Gmbh Combinacion farmaceutica.
WO2021209689A1 (en) * 2020-04-17 2021-10-21 Helsingin Yliopisto Compounds and compositions for treating sweet potato against sweet potato pathogenic viruses

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DE69029668T2 (de) * 1989-03-08 1997-08-07 Merck Sharp & Dohme Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
US5605906A (en) * 1995-03-24 1997-02-25 Merck Frosst Canada, Inc. Cannabinoid receptor agonists
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
JP3573679B2 (ja) * 2000-03-13 2004-10-06 独立行政法人 科学技術振興機構 高分子固定化α−イミノエステル

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WO2001058875A2 (de) 2001-08-16
US6699877B2 (en) 2004-03-02
US20030087926A1 (en) 2003-05-08
MXPA02007661A (es) 2002-12-13
AU2001226794B2 (en) 2005-06-02
HUP0301080A3 (en) 2010-04-28
NZ521088A (en) 2004-05-28
ES2250345T3 (es) 2006-04-16
DK1254118T3 (da) 2006-03-20
AU2679401A (en) 2001-08-20
AR029795A1 (es) 2003-07-16
DE10005302A1 (de) 2002-01-17
JP2003522758A (ja) 2003-07-29
DE50107988D1 (de) 2005-12-15
EP1254118B1 (de) 2005-11-09
CO5271673A1 (es) 2003-04-30
ATE309220T1 (de) 2005-11-15
WO2001058875A3 (de) 2002-01-24
EP1254118A2 (de) 2002-11-06
CA2416343A1 (en) 2001-08-16
PE20011079A1 (es) 2001-12-29

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