HUP0204252A2 - Eljárások a clarithromycin polimorf módosulatainak előállítására és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Eljárások a clarithromycin polimorf módosulatainak előállítására és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0204252A2
HUP0204252A2 HU0204252A HUP0204252A HUP0204252A2 HU P0204252 A2 HUP0204252 A2 HU P0204252A2 HU 0204252 A HU0204252 A HU 0204252A HU P0204252 A HUP0204252 A HU P0204252A HU P0204252 A2 HUP0204252 A2 HU P0204252A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
clarithromycin
clarithromycin form
preparing clarithromycin
Prior art date
Application number
HU0204252A
Other languages
English (en)
Inventor
Ilya Avrutov
Igor Lifshitz
Basem Masarwa
Edi Schwartz
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22640371&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0204252(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HUP0204252A2 publication Critical patent/HUP0204252A2/hu
Publication of HUP0204252A3 publication Critical patent/HUP0204252A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás clarithromycin I forma átalakításáraclarithromycin II formává oly módon, hogy a clarithromycin I formátvízben szuszpendálják. A találmány tárgya továbbá eljárásclarithromycin II forma előállítására erithromycin A átalakításávalclarithromycinné és ezt követően a clarithromycin I forma átalakításaszuszpendálással clarithromycin I formává. A találmány kiterjed az újpolimof módosulatokat tartalmazó gyógyszerkészítményekre is. Ó
HU0204252A 2000-01-11 2000-12-15 Process for preparing clarithromycin polymorphs and pharmaceutical compositions containing them HUP0204252A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17547700P 2000-01-11 2000-01-11
PCT/US2000/033844 WO2001051059A1 (en) 2000-01-11 2000-12-15 Processes for preparing clarithromycin polymorphs

Publications (2)

Publication Number Publication Date
HUP0204252A2 true HUP0204252A2 (hu) 2003-03-28
HUP0204252A3 HUP0204252A3 (en) 2003-04-28

Family

ID=22640371

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204252A HUP0204252A3 (en) 2000-01-11 2000-12-15 Process for preparing clarithromycin polymorphs and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US6624292B2 (hu)
EP (1) EP1280535B1 (hu)
JP (1) JP2003519661A (hu)
KR (1) KR20020071012A (hu)
CN (1) CN1450903A (hu)
AT (1) ATE288758T1 (hu)
AU (2) AU2261901A (hu)
BR (1) BR0016992A (hu)
CA (1) CA2397092A1 (hu)
DE (1) DE60018119T2 (hu)
DK (1) DK1280535T3 (hu)
ES (1) ES2236023T3 (hu)
HR (1) HRP20020572A2 (hu)
HU (1) HUP0204252A3 (hu)
IL (1) IL150698A0 (hu)
IS (1) IS6463A (hu)
PL (1) PL356645A1 (hu)
PT (1) PT1280535E (hu)
RU (1) RU2002118308A (hu)
SI (1) SI1280535T1 (hu)
WO (1) WO2001051059A1 (hu)
ZA (1) ZA200205229B (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2395555A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph iv
ES2236023T3 (es) * 2000-01-11 2005-07-16 Teva Pharmaceutical Industries Ltd. Procedimiento para preparacion de polimorfos de claritromicina.
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
CZ20023167A3 (cs) * 2000-02-29 2003-10-15 Teva Pharmaceutical Industries Ltd. Způsob přípravy klaritromycinu a klaritromycinového meziproduktu, v podstatě prostého oximu a farmaceutický prostředek, který jej obsahuje
IL151888A0 (en) * 2000-03-28 2003-04-10 Biochemie Gmbh Granulated particles with masked taste
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
DE60129133T2 (de) * 2001-08-13 2008-03-06 Fondazione Salvatore Maugeri - Clinica del Lavoro e della Riabilitazione Verwendung von Clarithromycin zur Herstellung eines Medikaments für die Behandlung von Arthrosis deformans
CA2533178C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533292C (en) 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258944B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1653925A1 (en) 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005023184A2 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005061524A2 (en) * 2003-12-22 2005-07-07 Ranbaxy Laboratories Limited Process for the preparation of form ii clarithromycin
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
EP1715971A4 (en) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc FUNCTIONALIZED COLLOIDAL METAL COMPOSITIONS AND METHODS
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
EP1771158A4 (en) 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSED DELIVERY
CA2614412A1 (en) * 2005-07-07 2007-01-18 Elan Pharma International, Limited Nanoparticulate clarithromycin formulations
US20070122483A1 (en) * 2005-11-29 2007-05-31 Sharon Myers Fluocinolone acetonide drug substance polymorphic interconversion
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2011026234A1 (en) * 2009-09-02 2011-03-10 Bernard Charles Sherman Clarithromycin extended-release tablet
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
US4672056A (en) 1985-11-12 1987-06-09 Abbott Laboratories Erythromycin A derivatives and method of use
US4640910A (en) 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
KR960000434B1 (ko) 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
GB8721165D0 (en) 1987-09-09 1987-10-14 Beecham Group Plc Chemical compounds
JP2751385B2 (ja) 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5440505A (en) * 1994-01-21 1995-08-08 Intel Corporation Method and circuitry for storing discrete amounts of charge in a single memory element
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5756473A (en) 1995-11-21 1998-05-26 Abbott Laboratories 6-O-methyl erythromycin D and process for making
US5719272A (en) 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5837829A (en) 1996-04-02 1998-11-17 Abbott Laboratories 9-oximesilyl erythromycin a derivatives
US5808017A (en) 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
US5858986A (en) 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
ES2173057T3 (es) 1996-07-29 2004-11-16 Abbott Laboratories Preparacion de la forma ii cristalina de claritromicina.
US5844105A (en) * 1996-07-29 1998-12-01 Abbott Laboratories Preparation of crystal form II of clarithromycin
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5852180A (en) 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en) 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
US5892008A (en) 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100377159B1 (ko) * 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
CA2395555A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph iv
ES2236023T3 (es) * 2000-01-11 2005-07-16 Teva Pharmaceutical Industries Ltd. Procedimiento para preparacion de polimorfos de claritromicina.
CZ20023167A3 (cs) 2000-02-29 2003-10-15 Teva Pharmaceutical Industries Ltd. Způsob přípravy klaritromycinu a klaritromycinového meziproduktu, v podstatě prostého oximu a farmaceutický prostředek, který jej obsahuje

Also Published As

Publication number Publication date
HRP20020572A2 (en) 2005-04-30
PL356645A1 (en) 2004-06-28
CA2397092A1 (en) 2001-07-19
DK1280535T3 (da) 2005-04-04
US6624292B2 (en) 2003-09-23
JP2003519661A (ja) 2003-06-24
PT1280535E (pt) 2005-04-29
AU2001222619B8 (en) 2005-07-14
ATE288758T1 (de) 2005-02-15
AU2001222619C1 (en) 2006-01-12
RU2002118308A (ru) 2004-02-20
US20030216555A1 (en) 2003-11-20
DE60018119T2 (de) 2006-05-04
AU2001222619B2 (en) 2005-04-28
ES2236023T3 (es) 2005-07-16
AU2261901A (en) 2001-07-24
IS6463A (is) 2002-07-09
CN1450903A (zh) 2003-10-22
DE60018119D1 (de) 2005-03-17
EP1280535A1 (en) 2003-02-05
EP1280535B1 (en) 2005-02-09
KR20020071012A (ko) 2002-09-11
EP1280535A4 (en) 2003-02-05
SI1280535T1 (hu) 2005-08-31
IL150698A0 (en) 2003-02-12
US6987175B2 (en) 2006-01-17
WO2001051059A1 (en) 2001-07-19
US20020028920A1 (en) 2002-03-07
BR0016992A (pt) 2002-12-31
HUP0204252A3 (en) 2003-04-28
ZA200205229B (en) 2003-06-30

Similar Documents

Publication Publication Date Title
HUP0204252A2 (hu) Eljárások a clarithromycin polimorf módosulatainak előállítására és ezeket tartalmazó gyógyszerkészítmények
HUP0204091A2 (hu) Eljárások a clarithromycin polimorf módosulatainak előállítására és az új polimorf IV módosulat, és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0402043A2 (hu) Rimonabant polimorf formája, eljárás ezen forma előállítására és ilyen polimorf formát tartalmazó gyógyászati készítmények
NZ534374A (en) Method of synthesizing camptothecin-relating compounds
PL392726A1 (pl) Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
AP1709A (en) Ethanolate of azithromycin, process for manufacure, and pharmaceutical compositions thereof.
HUP0203257A2 (hu) Atorvastatin kalcium polimorf módosulatai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HK1070063A1 (en) Stable polymorph of flibanserin, technical processfor its preparation and the use thereof for prepa ring medicaments
NO20030926D0 (no) Fremgangsmåte for fremstilling av hydrater av olanzapin og deres omdannelsetil krystallinske former av olanzapin
HUP0300701A2 (hu) Zolpidem hemitartarát, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmények
HUP9903458A3 (en) Process for producing pantothene acid by expression of ketopantoat-reductase codeing nucleotid sequencies
HUP0302874A2 (hu) Eljárás risperidon előállítására
SE9903291D0 (sv) New process
NO20032371L (no) Makrolidsolvater
HUP0204069A2 (hu) Új eljárás leflunomid előállítására és a leflunomid új kristályformája és ezt tartalmazó gyógyszerkészítmény
SG86468A1 (en) Production process of high-purity gypsum
ITMI20000026A0 (it) Procedimento per la produzione di gas di sintesi
GC0000363A (en) Process for the production of vinyl acetate
NO20020218L (no) Fremgangsmåte for fremstilling av mykner
YU53302A (sh) Postupci za pripremanje polimorfa klaritromicina
IL149089A0 (en) Method for production of benzofuranone oximes
ES2183718A1 (es) Nuevo procedimiento para la preparacion de hidroxiarilglicinas, alcoxiarilglicinas y sus glicinatos.
HUP0301331A3 (en) Antipicornaviral compounds process for their preparation and compositions containing them, their pharmaceutical uses, and intermediates for their synthesis
BR0104841A (pt) Método para preparação de citalopram, de um composto de fórmula iv, citalopram e sua composição farmacêutica
HUP0300504A2 (hu) 21,16alfa-laktongyűrűs 19-nor-17alfa-pregna-1,3,5(10)-trién-17béta-olok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees