HUP0203732A2 - Szubsztituált 1- és 2-naftol-mannichbázisok, e vegyületeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek előállítására - Google Patents

Szubsztituált 1- és 2-naftol-mannichbázisok, e vegyületeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek előállítására

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Publication number
HUP0203732A2
HUP0203732A2 HU0203732A HUP0203732A HUP0203732A2 HU P0203732 A2 HUP0203732 A2 HU P0203732A2 HU 0203732 A HU0203732 A HU 0203732A HU P0203732 A HUP0203732 A HU P0203732A HU P0203732 A2 HUP0203732 A2 HU P0203732A2
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Hungary
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group
general formula
aryl
heteroaryl
formula
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HU0203732A
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English (en)
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Matthias Gerlach
Corinna Maul
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Grünenthal GmbH.
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Publication of HUP0203732A2 publication Critical patent/HUP0203732A2/hu
Publication of HUP0203732A3 publication Critical patent/HUP0203732A3/hu

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

A találmány tárgyát az (I) általános képletű szubsztituált 1- és 2-naftol-Mannichbázisok, valamint ezeket tartalmazó gyógyászaikészítmények képezik; a találmány szerinti vegyületeket tartalmazógyógyászati készítmények eredményesen alkalmazható fájdalom, előnyösenkrónikus fájdalom és/vagy gyulladásos reakciók és/vagy allergiásreakciók és/vagy kábítószerfüggés és/vagy alkoholfüggés és/vagyhasmenés és/vagy gasztritisz és/vagy fekély és/vagy szív- ésérrendszeri megbetegedések és/vagy vizeletinkontinencia és/vagydepresszió és/vagy sokkos állapotok és/vagy migrén és/vagynarkolepszia és/vagy túlsúlyos állapotok és/vagy a asztma és/vagyglaukoma és/vagy hiperkinetikus szindróma kezelésére vagy leküzdésére.Az (I) általános képletben a szubsztituensek jelentése igen sokféle,így például R1 jelentése -CH(R9)N(R10)(R11) általános képletű csoportés R2 jelentése -OR12 általános képletű csoport, vagy R1 jelentése -OR12 általános képletű csoport és R2 jelentése -CH(R9)N(R10)(R11)általános képletű csoport, továbbá R3, R4, R5, R6, R7 és R8 jelentésepéldául fluor-, klór vagy brómatom, -CF3, -CN, -NO2, -SO2NH2 képletűcsoport, -SO2NHR13, -NHR13 általános képletű csoport, aril- vagyheteroarilcsoport, R9 jelentése aril-, heteroaril- vagy alkilcsoport,anélkül, hogy az a helyzetben savas proton lenne jelen, R10 és R11jelentése például alkilcsoport vagy legalább egy szubsztituensthordozó fenil-, benzil- vagy feniletilcsoport, vagy R10 és R11együttes jelentése (CH2)2O(CH2)2 vagy (CH2) a képletű csoport,ahol a értéke 3, 4, 5 vagy 6, R12 jelentése hidrogénatom, COR22általános képletű csoport, alkil-, aril-, heteroaril- vagyalkiléncsoporton keresztül kapcsolódó aril- vagy heteroarilcsoport,R13 jelentése például aril- vagy heteroarilcsoport. A találmánykiterjed a vegyületek előállítási eljárására is. Ó
HU0203732A 1999-12-27 2000-12-20 Substituted 1 and 2 naphthol mannich bases HUP0203732A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963179A DE19963179B4 (de) 1999-12-27 1999-12-27 Substituierte 1- und 2-Naphthol-Mannichbasen
PCT/EP2000/012972 WO2001047866A1 (de) 1999-12-27 2000-12-20 Substituierte 1- und 2-naphthol-mannichbasen

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HUP0203732A2 true HUP0203732A2 (hu) 2003-03-28
HUP0203732A3 HUP0203732A3 (en) 2005-01-28

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HU0203732A HUP0203732A3 (en) 1999-12-27 2000-12-20 Substituted 1 and 2 naphthol mannich bases

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US (2) US6774136B2 (hu)
EP (1) EP1246790B1 (hu)
JP (1) JP2003519115A (hu)
KR (1) KR20020062334A (hu)
CN (1) CN1247523C (hu)
AT (1) ATE294773T1 (hu)
AU (1) AU775709B2 (hu)
BR (1) BR0016781A (hu)
CA (1) CA2394098A1 (hu)
CO (1) CO5251380A1 (hu)
CZ (1) CZ20022240A3 (hu)
DE (2) DE19963179B4 (hu)
DK (1) DK1246790T3 (hu)
ES (1) ES2241688T3 (hu)
HK (1) HK1051845A1 (hu)
HU (1) HUP0203732A3 (hu)
IL (1) IL149920A (hu)
MX (1) MXPA02005865A (hu)
NO (1) NO20022896L (hu)
NZ (1) NZ519976A (hu)
PE (1) PE20010986A1 (hu)
PL (1) PL356523A1 (hu)
PT (1) PT1246790E (hu)
RU (1) RU2002120479A (hu)
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UY (1) UY26507A1 (hu)
WO (1) WO2001047866A1 (hu)
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DE102005033732B4 (de) * 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
US7964732B2 (en) 2006-11-17 2011-06-21 Pfizer Inc. Substituted bicyclocarboxyamide compounds
WO2011106226A2 (en) 2010-02-23 2011-09-01 Cornell University Prolylhydroxylase inhibitors and methods of use
US8883850B2 (en) 2010-05-28 2014-11-11 Merck Sharp & Dohme Corp. Naphthalene carboxamide M1 receptor positive allosteric modulators
CN103193676B (zh) * 2013-04-18 2014-03-19 安徽工业大学 一锅法合成1-氨甲酸酯基烷基-2-萘酚的方法
CN103664826B (zh) * 2014-01-07 2016-06-29 西北师范大学 一种氨基萘酚类化合物的制备方法

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AU4458996A (en) * 1995-01-20 1996-08-07 Nippon Shinyaku Co. Ltd. Ethylamine derivatives and drugs
DE19805370A1 (de) 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
WO1998058928A1 (fr) * 1997-06-23 1998-12-30 Yoshitomi Pharmaceutical Industries, Ltd. Agent prophylactique ou therapeutique contre des maladies attribuables a une infection par des helicobacters

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HUP0203732A3 (en) 2005-01-28
SK8532002A3 (en) 2003-05-02
WO2001047866A9 (de) 2002-11-07
CA2394098A1 (en) 2001-07-05
CN1413185A (zh) 2003-04-23
EP1246790A1 (de) 2002-10-09
CN1247523C (zh) 2006-03-29
NZ519976A (en) 2004-04-30
PE20010986A1 (es) 2001-10-06
WO2001047866A1 (de) 2001-07-05
DE19963179B4 (de) 2009-02-05
CO5251380A1 (es) 2003-02-28
PT1246790E (pt) 2005-09-30
DK1246790T3 (da) 2005-08-29
ATE294773T1 (de) 2005-05-15
JP2003519115A (ja) 2003-06-17
PL356523A1 (en) 2004-06-28
US6774136B2 (en) 2004-08-10
RU2002120479A (ru) 2004-01-10
CZ20022240A3 (cs) 2003-03-12
NO20022896D0 (no) 2002-06-17
EP1246790B1 (de) 2005-05-04
IL149920A (en) 2006-12-31
ES2241688T3 (es) 2005-11-01
ZA200204289B (en) 2004-02-10
US7202242B2 (en) 2007-04-10
NO20022896L (no) 2002-06-17
US20040044061A1 (en) 2004-03-04
MXPA02005865A (es) 2003-05-23
HK1051845A1 (en) 2003-08-22
BR0016781A (pt) 2002-08-27
UY26507A1 (es) 2001-01-31
DE50010253D1 (de) 2005-06-09
US20040147570A1 (en) 2004-07-29
AU3014701A (en) 2001-07-09
AU775709B2 (en) 2004-08-12
KR20020062334A (ko) 2002-07-25
DE19963179A1 (de) 2001-07-12

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