HUP0202706A2 - D4 antagonistákként alkalmazható benzizoxazolil-, piridoizoxazolil- és benzitienil-fenoxi-származékok, intermedierjeik, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
D4 antagonistákként alkalmazható benzizoxazolil-, piridoizoxazolil- és benzitienil-fenoxi-származékok, intermedierjeik, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0202706A2 HUP0202706A2 HU0202706A HUP0202706A HUP0202706A2 HU P0202706 A2 HUP0202706 A2 HU P0202706A2 HU 0202706 A HU0202706 A HU 0202706A HU P0202706 A HUP0202706 A HU P0202706A HU P0202706 A2 HUP0202706 A2 HU P0202706A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- benzisoxazolyl
- disorder
- pyridoisoxazolyl
- Prior art date
Links
- -1 Benzisoxazolyl- Chemical group 0.000 title abstract 5
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000027448 Attention Deficit and Disruptive Behavior disease Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000027691 Conduct disease Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 208000024196 oppositional defiant disease Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány tárgyát képezik a (I) általános képletű vegyületek, azokgyógyászatilag elfogadható sói vagy sztereoizomerjei - a képletben T,T' és T< jelentése - többek között C-, O- és N-atom, amely benzizoxazolil-csoportot képez, X jelentése hidrogén- vagy halogénatom; A jelentése - többek között- -CH2-CH2-csoport, R3 jelentése (CH2)nQ-, CH2CH(OH)Q- vagy CH(CH3)Q-,1, 2, 3, 4-tetrahidronaftil-, adott esetben hidroxilcsoporttalhelyettesített indanilcsoport vagy adamantilcsoport; n értéke 0, 2vagy 2; R4 jelentése - többek között - H-atom vagy 1-6 szénatomosalkilcsoport; m értéke 0 vagy 1. A vegyületek a benzizoxazolil-,piridoizoxazolil- és benztienil-fenoxi-származékok csoportjábatartoznak, amelyek D4-antagonistákként alkalmazhatók. Az említettvegyületek alkalmazhatók a D4-receptor gátlása által szabályozhatóorvosi állapotok kezelésében. Ezen állapotok körébe tartoznak példáula figyelemhiányos hiperaktivitási rendellenesség, a rögeszmés-kényszeres rendellenesség, pszichózisok, a drogokkal való visszaélés,a drogfüggőség, a Parkinson-kór, a parkinsonizmus, a retardáltdyskinesia, a Gilles de la Tourette szindróma, a magatartászavar és azellenkező-kihívó rendellenesség. A találmány tárgyát képezik továbbá atalálmány szerinti vegyületeket tartalmazó gyógyászati készítmények, avegyületek intermedierjei és a vegyületek említett csoportjánakelőállítására irányuló eljárások. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39593799A | 1999-09-14 | 1999-09-14 | |
| PCT/US2000/024961 WO2001019821A1 (en) | 1999-09-14 | 2000-09-13 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0202706A2 true HUP0202706A2 (hu) | 2002-12-28 |
| HUP0202706A3 HUP0202706A3 (en) | 2004-12-28 |
Family
ID=23565162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202706A HUP0202706A3 (en) | 1999-09-14 | 2000-09-13 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1216244B1 (hu) |
| JP (1) | JP4806149B2 (hu) |
| KR (1) | KR20020027648A (hu) |
| AT (1) | ATE247110T1 (hu) |
| AU (1) | AU7479400A (hu) |
| BR (1) | BR0014000A (hu) |
| CA (1) | CA2383332C (hu) |
| CZ (1) | CZ2002898A3 (hu) |
| DE (1) | DE60004543T2 (hu) |
| DK (1) | DK1216244T3 (hu) |
| EA (1) | EA200200356A1 (hu) |
| EE (1) | EE200200134A (hu) |
| ES (1) | ES2200934T3 (hu) |
| HR (1) | HRP20020219A2 (hu) |
| HU (1) | HUP0202706A3 (hu) |
| IL (1) | IL148622A0 (hu) |
| MX (1) | MXPA02002694A (hu) |
| NO (1) | NO20021256L (hu) |
| NZ (1) | NZ517516A (hu) |
| PL (1) | PL354514A1 (hu) |
| PT (1) | PT1216244E (hu) |
| SK (1) | SK3492002A3 (hu) |
| WO (1) | WO2001019821A1 (hu) |
| ZA (1) | ZA200201757B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1717235A3 (en) * | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
| GB201004311D0 (en) * | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| AU2011376717A1 (en) | 2011-09-14 | 2014-03-20 | Proximagen Limited | New enzyme inhibitor compounds |
| EP2935243B1 (en) | 2012-12-21 | 2018-03-14 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| US9611257B2 (en) | 2012-12-21 | 2017-04-04 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US9221794B2 (en) | 2012-12-21 | 2015-12-29 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| LT2935222T (lt) | 2012-12-21 | 2018-12-27 | Epizyme, Inc. | Prmt5 slopikliai ir jų panaudojimas |
| WO2015200680A2 (en) * | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2017205766A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
| US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5225412A (en) * | 1991-04-29 | 1993-07-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| US5576319A (en) * | 1993-03-01 | 1996-11-19 | Merck, Sharp & Dohme Ltd. | Pyrrolo-pyridine derivatives |
| HUP9900611A3 (en) * | 1995-12-21 | 2000-09-28 | Pfizer | 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives, pharmaceutical compositions containing them and intermediates for the preparation of the compounds |
| ATE227278T1 (de) * | 1996-04-19 | 2002-11-15 | Akzo Nobel Nv | Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression |
| FR2749304B1 (fr) * | 1996-06-04 | 1998-06-26 | Adir | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| JPH1095770A (ja) * | 1996-09-20 | 1998-04-14 | Taisho Pharmaceut Co Ltd | ４−ベンジリデンピペリジン誘導体 |
| PT1054885E (pt) * | 1998-02-09 | 2007-10-03 | Duphar Int Res | Derivativos de benzisoxazole tendo uma actividade d4-antagonista |
-
2000
- 2000-09-13 NZ NZ517516A patent/NZ517516A/en not_active Application Discontinuation
- 2000-09-13 DK DK00963370T patent/DK1216244T3/da active
- 2000-09-13 CA CA002383332A patent/CA2383332C/en not_active Expired - Fee Related
- 2000-09-13 ES ES00963370T patent/ES2200934T3/es not_active Expired - Lifetime
- 2000-09-13 EA EA200200356A patent/EA200200356A1/ru unknown
- 2000-09-13 SK SK349-2002A patent/SK3492002A3/sk unknown
- 2000-09-13 BR BR0014000-7A patent/BR0014000A/pt not_active IP Right Cessation
- 2000-09-13 IL IL14862200A patent/IL148622A0/xx unknown
- 2000-09-13 EP EP00963370A patent/EP1216244B1/en not_active Expired - Lifetime
- 2000-09-13 PT PT00963370T patent/PT1216244E/pt unknown
- 2000-09-13 CZ CZ2002898A patent/CZ2002898A3/cs unknown
- 2000-09-13 KR KR1020027003367A patent/KR20020027648A/ko not_active Application Discontinuation
- 2000-09-13 PL PL00354514A patent/PL354514A1/xx unknown
- 2000-09-13 JP JP2001523398A patent/JP4806149B2/ja not_active Expired - Fee Related
- 2000-09-13 AU AU74794/00A patent/AU7479400A/en not_active Abandoned
- 2000-09-13 WO PCT/US2000/024961 patent/WO2001019821A1/en not_active Application Discontinuation
- 2000-09-13 EE EEP200200134A patent/EE200200134A/xx unknown
- 2000-09-13 HU HU0202706A patent/HUP0202706A3/hu unknown
- 2000-09-13 DE DE60004543T patent/DE60004543T2/de not_active Expired - Lifetime
- 2000-09-13 MX MXPA02002694A patent/MXPA02002694A/es active IP Right Grant
- 2000-09-13 AT AT00963370T patent/ATE247110T1/de not_active IP Right Cessation
-
2002
- 2002-03-01 ZA ZA200201757A patent/ZA200201757B/xx unknown
- 2002-03-12 HR HR20020219A patent/HRP20020219A2/xx not_active Application Discontinuation
- 2002-03-13 NO NO20021256A patent/NO20021256L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1216244E (pt) | 2003-12-31 |
| AU7479400A (en) | 2001-04-17 |
| DE60004543T2 (de) | 2004-06-17 |
| EE200200134A (et) | 2003-04-15 |
| NZ517516A (en) | 2003-11-28 |
| ES2200934T3 (es) | 2004-03-16 |
| EP1216244A1 (en) | 2002-06-26 |
| PL354514A1 (en) | 2004-01-26 |
| SK3492002A3 (en) | 2002-12-03 |
| NO20021256D0 (no) | 2002-03-13 |
| CA2383332C (en) | 2006-01-10 |
| NO20021256L (no) | 2002-05-14 |
| DK1216244T3 (da) | 2003-11-17 |
| CZ2002898A3 (cs) | 2002-07-17 |
| HRP20020219A2 (en) | 2004-04-30 |
| KR20020027648A (ko) | 2002-04-13 |
| BR0014000A (pt) | 2002-05-14 |
| JP2003509421A (ja) | 2003-03-11 |
| EA200200356A1 (ru) | 2002-10-31 |
| ATE247110T1 (de) | 2003-08-15 |
| WO2001019821A1 (en) | 2001-03-22 |
| EP1216244B1 (en) | 2003-08-13 |
| ZA200201757B (en) | 2003-08-27 |
| IL148622A0 (en) | 2002-09-12 |
| MXPA02002694A (es) | 2002-07-30 |
| JP4806149B2 (ja) | 2011-11-02 |
| CA2383332A1 (en) | 2001-03-22 |
| DE60004543D1 (de) | 2003-09-18 |
| HUP0202706A3 (en) | 2004-12-28 |
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