PT1216244E - Derivados de benzisoxazolil- piridoisoxazolil- e benztienil-fenoxi uteis como antagonistas d4 - Google Patents
Derivados de benzisoxazolil- piridoisoxazolil- e benztienil-fenoxi uteis como antagonistas d4Info
- Publication number
- PT1216244E PT1216244E PT00963370T PT00963370T PT1216244E PT 1216244 E PT1216244 E PT 1216244E PT 00963370 T PT00963370 T PT 00963370T PT 00963370 T PT00963370 T PT 00963370T PT 1216244 E PT1216244 E PT 1216244E
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- disorder
- pyridoisoxazolyl
- benzisoxazolyl
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39593799A | 1999-09-14 | 1999-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1216244E true PT1216244E (pt) | 2003-12-31 |
Family
ID=23565162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00963370T PT1216244E (pt) | 1999-09-14 | 2000-09-13 | Derivados de benzisoxazolil- piridoisoxazolil- e benztienil-fenoxi uteis como antagonistas d4 |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1216244B1 (pt) |
| JP (1) | JP4806149B2 (pt) |
| KR (1) | KR20020027648A (pt) |
| AT (1) | ATE247110T1 (pt) |
| AU (1) | AU7479400A (pt) |
| BR (1) | BR0014000A (pt) |
| CA (1) | CA2383332C (pt) |
| CZ (1) | CZ2002898A3 (pt) |
| DE (1) | DE60004543T2 (pt) |
| DK (1) | DK1216244T3 (pt) |
| EA (1) | EA200200356A1 (pt) |
| EE (1) | EE200200134A (pt) |
| ES (1) | ES2200934T3 (pt) |
| HR (1) | HRP20020219A2 (pt) |
| HU (1) | HUP0202706A3 (pt) |
| IL (1) | IL148622A0 (pt) |
| MX (1) | MXPA02002694A (pt) |
| NO (1) | NO20021256L (pt) |
| NZ (1) | NZ517516A (pt) |
| PL (1) | PL354514A1 (pt) |
| PT (1) | PT1216244E (pt) |
| SK (1) | SK3492002A3 (pt) |
| WO (1) | WO2001019821A1 (pt) |
| ZA (1) | ZA200201757B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
| GB201004311D0 (en) * | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| JP5796130B2 (ja) | 2011-09-14 | 2015-10-21 | プロクシマゲン リミテッド | 新規な酵素阻害剤化合物 |
| CA2894130A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CA2894126A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2014100734A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| MX2015008052A (es) | 2012-12-21 | 2016-08-18 | Epizyme Inc | Inhibidores de prmt5 y sus usos. |
| CA2899363A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US20170198006A1 (en) * | 2014-06-25 | 2017-07-13 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3177288A4 (en) | 2014-08-04 | 2018-04-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2017205766A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
| US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5225412A (en) * | 1991-04-29 | 1993-07-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| US5576319A (en) * | 1993-03-01 | 1996-11-19 | Merck, Sharp & Dohme Ltd. | Pyrrolo-pyridine derivatives |
| JP3204456B2 (ja) * | 1995-12-21 | 2001-09-04 | ファイザー・インコーポレーテッド | ２，７―置換オクタヒドロ―ピロロ［１，２―ａ］ピラジン誘導体 |
| DK0898566T3 (da) * | 1996-04-19 | 2003-03-03 | Akzo Nobel Nv | Substituerede benzylaminer og anvendelse deraf til behandling af depression |
| FR2749304B1 (fr) * | 1996-06-04 | 1998-06-26 | Adir | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| JPH1095770A (ja) * | 1996-09-20 | 1998-04-14 | Taisho Pharmaceut Co Ltd | ４−ベンジリデンピペリジン誘導体 |
| DK1054885T3 (da) * | 1998-02-09 | 2007-10-15 | Duphar Int Res | Benzisoxasolderivater med D4-antagonistisk virkning |
-
2000
- 2000-09-13 EE EEP200200134A patent/EE200200134A/xx unknown
- 2000-09-13 DK DK00963370T patent/DK1216244T3/da active
- 2000-09-13 CA CA002383332A patent/CA2383332C/en not_active Expired - Fee Related
- 2000-09-13 ES ES00963370T patent/ES2200934T3/es not_active Expired - Lifetime
- 2000-09-13 BR BR0014000-7A patent/BR0014000A/pt not_active IP Right Cessation
- 2000-09-13 CZ CZ2002898A patent/CZ2002898A3/cs unknown
- 2000-09-13 EP EP00963370A patent/EP1216244B1/en not_active Expired - Lifetime
- 2000-09-13 JP JP2001523398A patent/JP4806149B2/ja not_active Expired - Fee Related
- 2000-09-13 SK SK349-2002A patent/SK3492002A3/sk unknown
- 2000-09-13 DE DE60004543T patent/DE60004543T2/de not_active Expired - Lifetime
- 2000-09-13 KR KR1020027003367A patent/KR20020027648A/ko not_active Application Discontinuation
- 2000-09-13 EA EA200200356A patent/EA200200356A1/ru unknown
- 2000-09-13 MX MXPA02002694A patent/MXPA02002694A/es active IP Right Grant
- 2000-09-13 PL PL00354514A patent/PL354514A1/xx unknown
- 2000-09-13 NZ NZ517516A patent/NZ517516A/en not_active Application Discontinuation
- 2000-09-13 HU HU0202706A patent/HUP0202706A3/hu unknown
- 2000-09-13 PT PT00963370T patent/PT1216244E/pt unknown
- 2000-09-13 AU AU74794/00A patent/AU7479400A/en not_active Abandoned
- 2000-09-13 AT AT00963370T patent/ATE247110T1/de not_active IP Right Cessation
- 2000-09-13 WO PCT/US2000/024961 patent/WO2001019821A1/en not_active Application Discontinuation
- 2000-09-13 IL IL14862200A patent/IL148622A0/xx unknown
-
2002
- 2002-03-01 ZA ZA200201757A patent/ZA200201757B/xx unknown
- 2002-03-12 HR HR20020219A patent/HRP20020219A2/xx not_active Application Discontinuation
- 2002-03-13 NO NO20021256A patent/NO20021256L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1216244B1 (en) | 2003-08-13 |
| DK1216244T3 (da) | 2003-11-17 |
| EA200200356A1 (ru) | 2002-10-31 |
| KR20020027648A (ko) | 2002-04-13 |
| MXPA02002694A (es) | 2002-07-30 |
| ES2200934T3 (es) | 2004-03-16 |
| SK3492002A3 (en) | 2002-12-03 |
| NZ517516A (en) | 2003-11-28 |
| JP4806149B2 (ja) | 2011-11-02 |
| NO20021256L (no) | 2002-05-14 |
| CZ2002898A3 (cs) | 2002-07-17 |
| HRP20020219A2 (en) | 2004-04-30 |
| DE60004543T2 (de) | 2004-06-17 |
| HUP0202706A2 (hu) | 2002-12-28 |
| WO2001019821A1 (en) | 2001-03-22 |
| EE200200134A (et) | 2003-04-15 |
| IL148622A0 (en) | 2002-09-12 |
| CA2383332C (en) | 2006-01-10 |
| NO20021256D0 (no) | 2002-03-13 |
| BR0014000A (pt) | 2002-05-14 |
| DE60004543D1 (de) | 2003-09-18 |
| HUP0202706A3 (en) | 2004-12-28 |
| EP1216244A1 (en) | 2002-06-26 |
| AU7479400A (en) | 2001-04-17 |
| CA2383332A1 (en) | 2001-03-22 |
| PL354514A1 (en) | 2004-01-26 |
| ZA200201757B (en) | 2003-08-27 |
| JP2003509421A (ja) | 2003-03-11 |
| ATE247110T1 (de) | 2003-08-15 |
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