WO2008093920A3 - 1,2-dihydro-1-oxophthalazinyl derivatives having biological activity on serotonin receptors 5-ht2a and 5-ht2c, and preparation thereof - Google Patents

1,2-dihydro-1-oxophthalazinyl derivatives having biological activity on serotonin receptors 5-ht2a and 5-ht2c, and preparation thereof Download PDF

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Publication number
WO2008093920A3
WO2008093920A3 PCT/KR2007/003198 KR2007003198W WO2008093920A3 WO 2008093920 A3 WO2008093920 A3 WO 2008093920A3 KR 2007003198 W KR2007003198 W KR 2007003198W WO 2008093920 A3 WO2008093920 A3 WO 2008093920A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxophthalazinyl
dihydro
preparation
biological activity
ht2c
Prior art date
Application number
PCT/KR2007/003198
Other languages
French (fr)
Other versions
WO2008093920A2 (en
Inventor
Ae Nim Pae
Yong Seo Cho
Hyunah Choo
Joo Hwan Cha
Ji Hye Kim
Hun Yeong Koh
Woo-Kyu Park
Jae Yang Kong
Myeong Yun Chae
Insun Cho
Bong Woon Hwang
Dong Ha Lee
Original Assignee
Dongbu Hitek Co Ltd
Korea Inst Sci & Tech
Ae Nim Pae
Yong Seo Cho
Hyunah Choo
Joo Hwan Cha
Ji Hye Kim
Hun Yeong Koh
Woo-Kyu Park
Jae Yang Kong
Myeong Yun Chae
Insun Cho
Bong Woon Hwang
Dong Ha Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongbu Hitek Co Ltd, Korea Inst Sci & Tech, Ae Nim Pae, Yong Seo Cho, Hyunah Choo, Joo Hwan Cha, Ji Hye Kim, Hun Yeong Koh, Woo-Kyu Park, Jae Yang Kong, Myeong Yun Chae, Insun Cho, Bong Woon Hwang, Dong Ha Lee filed Critical Dongbu Hitek Co Ltd
Publication of WO2008093920A2 publication Critical patent/WO2008093920A2/en
Publication of WO2008093920A3 publication Critical patent/WO2008093920A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine

Abstract

The present invention relates to a novel 1,2-dihydro-1-oxophthalazinyl piperazine compound having biological activity as serotonin receptor antagonist, a preparation method of the compound and a pharmaceutical composition for the treatment and prevention of central nervous system diseases comprising the compound.
PCT/KR2007/003198 2007-01-30 2007-07-02 1,2-dihydro-1-oxophthalazinyl derivatives having biological activity on serotonin receptors 5-ht2a and 5-ht2c, and preparation thereof WO2008093920A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070009627A KR100843352B1 (en) 2007-01-30 2007-01-30 New 1,2-dihydro-1-oxophthalazinyl piperazine derivatives having biological activity on serotonin receptor 5-ht2a and 5-ht2c, and preparation thereof
KR10-2007-0009627 2007-01-30

Publications (2)

Publication Number Publication Date
WO2008093920A2 WO2008093920A2 (en) 2008-08-07
WO2008093920A3 true WO2008093920A3 (en) 2009-05-28

Family

ID=39674602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2007/003198 WO2008093920A2 (en) 2007-01-30 2007-07-02 1,2-dihydro-1-oxophthalazinyl derivatives having biological activity on serotonin receptors 5-ht2a and 5-ht2c, and preparation thereof

Country Status (2)

Country Link
KR (1) KR100843352B1 (en)
WO (1) WO2008093920A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0436307A1 (en) * 1989-12-15 1991-07-10 Pfizer Inc. Substituted oxophthalazinyl acetic acids and analogs thereof
WO2002085885A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402542D0 (en) * 1994-02-10 1994-04-06 Smith Kline Beecham Plc Novel compounds
WO2001068585A1 (en) * 2000-03-14 2001-09-20 Fujisawa Pharmaceutical Co., Ltd. Novel amide compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0436307A1 (en) * 1989-12-15 1991-07-10 Pfizer Inc. Substituted oxophthalazinyl acetic acids and analogs thereof
WO2002085885A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor

Also Published As

Publication number Publication date
WO2008093920A2 (en) 2008-08-07
KR100843352B1 (en) 2008-07-03

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