HUP0104959A2 - 4-Kinolinkarboxamid-származékok, előállításuk, neurokinin-2 (NK-2) és neurokinin-3 (NK-3) receptor antagonistákként történő felhasználásuk, valamint a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

4-Kinolinkarboxamid-származékok, előállításuk, neurokinin-2 (NK-2) és neurokinin-3 (NK-3) receptor antagonistákként történő felhasználásuk, valamint a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0104959A2
HUP0104959A2 HU0104959A HUP0104959A HUP0104959A2 HU P0104959 A2 HUP0104959 A2 HU P0104959A2 HU 0104959 A HU0104959 A HU 0104959A HU P0104959 A HUP0104959 A HU P0104959A HU P0104959 A2 HUP0104959 A2 HU P0104959A2
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Hungary
Prior art keywords
alkyl
group
cycloalkyl
optionally substituted
aryl
Prior art date
Application number
HU0104959A
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English (en)
Inventor
Carlo Farina
Giuseppe Giardina
Mario Grugni
Marcel Morvan
Guy Marguerite Marie Gérard Nadler
Luca Francesco Raveglia
Original Assignee
Laboratoire Glaxosmithkline
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GBGB9825553.2A external-priority patent/GB9825553D0/en
Priority claimed from GBGB9825552.4A external-priority patent/GB9825552D0/en
Application filed by Laboratoire Glaxosmithkline, Smithkline Beecham S.P.A. filed Critical Laboratoire Glaxosmithkline
Publication of HUP0104959A2 publication Critical patent/HUP0104959A2/hu
Publication of HUP0104959A3 publication Critical patent/HUP0104959A3/hu

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Abstract

A tal lm ny egy (I) ltal nos képletű vegyületre - amelynek képletébenAr adott esetben szubsztitu lt aril-, cikloalkadienil-, adott esetbenszubsztitu lt cikloalkil-, vagy adott esetben szubsztitu lt,monociklusos vagy kondenz lt gyűrűs, arom s heterociklusos csoport; Rhidrogénatom, alkil-, cikloalkil-, cikloalkil-alkil-csoport; R1hidrogénatom vagy adott esetben legfeljebb h rom alkil-, alkenil-,aril-, alkoxi-, hidroxicsoport, halogénatom, nitro-, ciano-, karboxi-,karboxamido-, szulfonamido-, alkoxi-karbonil-, trifluor- metil-, acil-oxi-, amino-, mono- vagy dialkil-aminocsoport; R2 -(CH2)n-NY1Y2 ltalnos képletű csoport, amelyben n , 1, 2, 3, 4, 5, 6, 7, 8 vagy 9,valamint Y1 és Y2 alkilcsoport; hidroxi-, alkoxi-, alkil-amino- vagydialkil-aminocsoporttal szubsztitu lt alkilcsoport; cikloalkilcsoport;aza-cikloalkilcsoport; alkenilcsoport; aril- vagy aril-(1-6 szénatomosalkil)-csoport; vagy Y1 és Y2 azzal a nitrogénatommal együtt, amelyhezkapcsolódik, egy adott esetben szubsztitu lt, nitrogénatomon keresztülkapcsolódó monociklusos vagy kondenz lt gyűrűs heterociklusoscsoportot képez; R3 alkil-, cikloalkil-, cikloalkil-alkil-, adottesetben szubsztitu lt arilcsoport, vagy adott esetben szubsztitu lt,monociklusos vagy kondenz lt gyűrűs, arom s heterociklusos csoport; R4hidrogénatom vagy alkilcsoport; és R5 jelentése hidrogén- vagyhalogénatom vagy a vegyületnek szolv tjaira vagy sóira vonatkozik. Atal lm ny kiterjed a vegyületek elő llít si elj r saira, avegyületeket tartalmazó gyógyszerkészítményekre és a vegyületek gyógy- szati felhaszn l s ra is. Ó
HU0104959A 1998-11-20 1999-11-19 Quinoline-4-carboxamide derivatives their preparation, their use as nk-3 and nk-2 receptor antagonists and medicaments containing them HUP0104959A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9825553.2A GB9825553D0 (en) 1998-11-20 1998-11-20 Novel Compounds
GBGB9825552.4A GB9825552D0 (en) 1998-11-20 1998-11-20 Novel compounds
PCT/EP1999/009115 WO2000031037A1 (en) 1998-11-20 1999-11-19 Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Publications (2)

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HUP0104959A2 true HUP0104959A2 (hu) 2002-04-29
HUP0104959A3 HUP0104959A3 (en) 2003-01-28

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HU0104959A HUP0104959A3 (en) 1998-11-20 1999-11-19 Quinoline-4-carboxamide derivatives their preparation, their use as nk-3 and nk-2 receptor antagonists and medicaments containing them

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EP (1) EP1131295A1 (hu)
JP (1) JP2002530377A (hu)
KR (1) KR20010075726A (hu)
CN (1) CN1406225A (hu)
AR (2) AR021355A1 (hu)
AU (1) AU768708B2 (hu)
BR (1) BR9915475A (hu)
CA (1) CA2351865A1 (hu)
CO (1) CO5150149A1 (hu)
HK (1) HK1041257A1 (hu)
HU (1) HUP0104959A3 (hu)
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JP2002530377A (ja) 2002-09-17
AR021354A1 (es) 2002-07-17
PL347721A1 (en) 2002-04-22
NZ511777A (en) 2003-12-19
CA2351865A1 (en) 2000-06-02
MXPA01005095A (es) 2002-04-24
AU1777000A (en) 2000-06-13
NO20012473D0 (no) 2001-05-18
HUP0104959A3 (en) 2003-01-28
HK1041257A1 (zh) 2002-07-05
KR20010075726A (ko) 2001-08-09
TR200101412T2 (tr) 2001-10-22
IL143137A0 (en) 2002-04-21
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NO20012473L (no) 2001-07-18
CO5150149A1 (es) 2002-04-29
BR9915475A (pt) 2001-12-18
CN1406225A (zh) 2003-03-26

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