HUP0104067A2 - Új eljárás béta-alanin származék előállítására - Google Patents

Új eljárás béta-alanin származék előállítására

Info

Publication number
HUP0104067A2
HUP0104067A2 HU0104067A HUP0104067A HUP0104067A2 HU P0104067 A2 HUP0104067 A2 HU P0104067A2 HU 0104067 A HU0104067 A HU 0104067A HU P0104067 A HUP0104067 A HU P0104067A HU P0104067 A2 HUP0104067 A2 HU P0104067A2
Authority
HU
Hungary
Prior art keywords
betha
producing
alanine derivative
new processes
group
Prior art date
Application number
HU0104067A
Other languages
English (en)
Inventor
Yosuke Fujii
Shunsuke Goto
Keiichi Koga
Satoru Kuroda
Hideko Nakamura
Mitsuru Ohkubo
Eiki Oikawa
Ryoki Orii
Hisashi Takasugi
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP0104067A2 publication Critical patent/HUP0104067A2/hu
Publication of HUP0104067A3 publication Critical patent/HUP0104067A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A jelen találmány tárgya az (I) általános képletű b-alanin-származékelőállítására szolgáló eljárás, ahol a képletben R1 jelentéseaminovédő csoport, valamint R2 jelentése acilcsoport, oly módon, hogya (II) általános képletű vegyületből vagy annak sójából kiindulva,ahol a képletben R1 jelentése azonos a fentiekben definiáltakkal,valamint R3 jelentése védett karboxicsoport, karboxivédő csoporteltávolítási reakciót és ezt követően aminocsoport-acilezési reakcióthajtanak végre. Ó
HU0104067A 1998-10-12 1999-10-07 New processes for producing betha-alanine derivative HUP0104067A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP6465A AUPP646598A0 (en) 1998-10-12 1998-10-12 New processes for producing alpha-alanine derivative
PCT/JP1999/005520 WO2000021932A1 (en) 1998-10-12 1999-10-07 NEW PROCESSES FOR PRODUCING β-ALANINE DERIVATIVE

Publications (2)

Publication Number Publication Date
HUP0104067A2 true HUP0104067A2 (hu) 2002-03-28
HUP0104067A3 HUP0104067A3 (en) 2002-04-29

Family

ID=3810687

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104067A HUP0104067A3 (en) 1998-10-12 1999-10-07 New processes for producing betha-alanine derivative

Country Status (16)

Country Link
US (2) US6538007B1 (hu)
EP (1) EP1121346A1 (hu)
JP (1) JP2002527424A (hu)
KR (1) KR20010075623A (hu)
CN (1) CN1329595A (hu)
AR (1) AR020768A1 (hu)
AU (1) AUPP646598A0 (hu)
BR (1) BR9914780A (hu)
CA (1) CA2346433A1 (hu)
CZ (1) CZ20011324A3 (hu)
HK (1) HK1043120A1 (hu)
HU (1) HUP0104067A3 (hu)
TR (1) TR200101040T2 (hu)
TW (1) TW490460B (hu)
WO (1) WO2000021932A1 (hu)
ZA (1) ZA200102781B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010051730A1 (en) * 1993-09-22 2001-12-13 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivative and a process for the preparation thereof
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
EP2404899A1 (en) 2004-02-25 2012-01-11 Astellas Pharma Inc. Contrast medium for thrombus detection
CN105017134A (zh) * 2015-07-26 2015-11-04 陈吉美 一种4-吡啶丙烯酸的制备方法
BR112019009293A2 (pt) 2016-11-08 2019-07-30 Bristol-Myers Squibb Company pirrol amidas como inibidores de integrina alfa v
CN110078657A (zh) * 2019-04-10 2019-08-02 湖州复华春生物医药科技有限公司 一种手性3-氨基哌啶及其衍生物的合成方法
CN109970585A (zh) * 2019-04-29 2019-07-05 安徽安力肽生物科技有限公司 一种β-丙氨酸酯类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008536A1 (en) * 1993-09-22 1995-03-30 Fujisawa Pharmaceutical Co., Ltd. N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists
KR19980703107A (ko) * 1995-03-17 1998-10-15 후지야마 아키라 N-아실피페리디닐카보닐아미노카복실산 및 당단백질 IIB/IIa 길항제와 피브리노겐-혈소판 결합 억제제로서의 이의 용도
EP0888302A1 (en) 1996-03-13 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. N- (r)-1- 3-(4-piperidyl)propionyl-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist

Also Published As

Publication number Publication date
JP2002527424A (ja) 2002-08-27
AR020768A1 (es) 2002-05-29
TW490460B (en) 2002-06-11
ZA200102781B (en) 2002-07-04
WO2000021932A1 (en) 2000-04-20
EP1121346A1 (en) 2001-08-08
US20030114488A1 (en) 2003-06-19
CN1329595A (zh) 2002-01-02
TR200101040T2 (tr) 2001-08-21
KR20010075623A (ko) 2001-08-09
CZ20011324A3 (cs) 2001-08-15
CA2346433A1 (en) 2000-04-20
BR9914780A (pt) 2001-10-30
HK1043120A1 (zh) 2002-09-06
HUP0104067A3 (en) 2002-04-29
US6538007B1 (en) 2003-03-25
AUPP646598A0 (en) 1998-11-05

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