BR9914780A - Processo de preparação de um composto defórmula (i) e composto produzido através de talprocesso - Google Patents

Processo de preparação de um composto defórmula (i) e composto produzido através de talprocesso

Info

Publication number
BR9914780A
BR9914780A BR9914780-7A BR9914780A BR9914780A BR 9914780 A BR9914780 A BR 9914780A BR 9914780 A BR9914780 A BR 9914780A BR 9914780 A BR9914780 A BR 9914780A
Authority
BR
Brazil
Prior art keywords
compound
formula
preparing
salt
produced
Prior art date
Application number
BR9914780-7A
Other languages
English (en)
Inventor
Mitsuru Ohkubo
Satoru Kuroda
Hideko Nakamura
Hisashitakasugi
Youke Fujii
Keiichi Koga
Eiki Oikawa
Ryoki Orii
Hunsuke Goto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of BR9914780A publication Critical patent/BR9914780A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO DE PREPARAçãO DE UM COMPOSTO DEFóRMULA (I) E COMPOSTO PRODUZIDO ATRAVéS DE TALPROCESSO". A presente invenção refere-se a processos para apreparação de derivado de <225>-alanina conforme mostra aseguinte fórmula (I): onde R^ 1^ é grupo amino-protetor, e R^ 2^ égrupo acila, ou um sal do mesmo, que compreende submeter umcomposto da fórmula (II): onde R^ 1^ é o mesmo conforme definidoacima, e R^ 3^ é carboxi protegido, ou um sal, à reação deeliminação de grupo carboxiprotetor, e então à reação de acilaçãode grupo amino.
BR9914780-7A 1998-10-12 1999-10-07 Processo de preparação de um composto defórmula (i) e composto produzido através de talprocesso BR9914780A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP6465A AUPP646598A0 (en) 1998-10-12 1998-10-12 New processes for producing alpha-alanine derivative
PCT/JP1999/005520 WO2000021932A1 (en) 1998-10-12 1999-10-07 NEW PROCESSES FOR PRODUCING β-ALANINE DERIVATIVE

Publications (1)

Publication Number Publication Date
BR9914780A true BR9914780A (pt) 2001-10-30

Family

ID=3810687

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914780-7A BR9914780A (pt) 1998-10-12 1999-10-07 Processo de preparação de um composto defórmula (i) e composto produzido através de talprocesso

Country Status (16)

Country Link
US (2) US6538007B1 (pt)
EP (1) EP1121346A1 (pt)
JP (1) JP2002527424A (pt)
KR (1) KR20010075623A (pt)
CN (1) CN1329595A (pt)
AR (1) AR020768A1 (pt)
AU (1) AUPP646598A0 (pt)
BR (1) BR9914780A (pt)
CA (1) CA2346433A1 (pt)
CZ (1) CZ20011324A3 (pt)
HK (1) HK1043120A1 (pt)
HU (1) HUP0104067A3 (pt)
TR (1) TR200101040T2 (pt)
TW (1) TW490460B (pt)
WO (1) WO2000021932A1 (pt)
ZA (1) ZA200102781B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010051730A1 (en) * 1993-09-22 2001-12-13 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivative and a process for the preparation thereof
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
US20070189970A1 (en) 2004-02-25 2007-08-16 Astellas Pharma Inc. Contrast medium for thrombus formation
CN105017134A (zh) * 2015-07-26 2015-11-04 陈吉美 一种4-吡啶丙烯酸的制备方法
PT3538528T (pt) 2016-11-08 2021-02-16 Bristol Myers Squibb Co Pirrol amidas como inibidores de integrina v
CN110078657A (zh) * 2019-04-10 2019-08-02 湖州复华春生物医药科技有限公司 一种手性3-氨基哌啶及其衍生物的合成方法
CN109970585A (zh) * 2019-04-29 2019-07-05 安徽安力肽生物科技有限公司 一种β-丙氨酸酯类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008536A1 (en) 1993-09-22 1995-03-30 Fujisawa Pharmaceutical Co., Ltd. N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists
US6384028B1 (en) * 1995-03-17 2002-05-07 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors
JP2000506524A (ja) * 1996-03-13 2000-05-30 藤沢薬品工業株式会社 フィブリノーゲン受容体拮抗剤であるＮ―［（Ｒ）―１―｛３―（４―ピペリジル）プロピオニル｝―３―ピペリジルカルボニル］―２（Ｓ）―アセチルアミノ―β―アラニン

Also Published As

Publication number Publication date
CZ20011324A3 (cs) 2001-08-15
EP1121346A1 (en) 2001-08-08
HK1043120A1 (zh) 2002-09-06
WO2000021932A1 (en) 2000-04-20
US6538007B1 (en) 2003-03-25
ZA200102781B (en) 2002-07-04
US20030114488A1 (en) 2003-06-19
HUP0104067A2 (hu) 2002-03-28
AR020768A1 (es) 2002-05-29
CN1329595A (zh) 2002-01-02
AUPP646598A0 (en) 1998-11-05
KR20010075623A (ko) 2001-08-09
CA2346433A1 (en) 2000-04-20
HUP0104067A3 (en) 2002-04-29
JP2002527424A (ja) 2002-08-27
TR200101040T2 (tr) 2001-08-21
TW490460B (en) 2002-06-11

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]