HUP0103577A2 - Optikai lemez alapú eszközök és eljárások - Google Patents

Optikai lemez alapú eszközök és eljárások

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Publication number
HUP0103577A2
HUP0103577A2 HU0103577A HUP0103577A HUP0103577A2 HU P0103577 A2 HUP0103577 A2 HU P0103577A2 HU 0103577 A HU0103577 A HU 0103577A HU P0103577 A HUP0103577 A HU P0103577A HU P0103577 A2 HUP0103577 A2 HU P0103577A2
Authority
HU
Hungary
Prior art keywords
methods
signal
component
test
substrate
Prior art date
Application number
HU0103577A
Other languages
English (en)
Inventor
Jorma Virtanen
Original Assignee
Burstein Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burstein Technologies, Inc. filed Critical Burstein Technologies, Inc.
Publication of HUP0103577A2 publication Critical patent/HUP0103577A2/hu

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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
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  • Optical Measuring Cells (AREA)

Abstract

A találmány tárgyát olyan optikai lemez alapú vizsgálati eszközökképezik, amelyekben egy optikai lemez szubsztrátjánkomponensspecifikus szignálelemek vannak elhelyezve, továbbá aszignálelemek, eljárások ezek előállítására és vizsgálandó komponensekvizsgálatára és mérésére, valamint mérőeszközök. A találmány előnyösmegvalósítási módjaiban a komponensspecifikus szignálelemek a lemezsávkövetési rendszerével leolvasható módon helyezkednek el. Előnyösen,amikor a kiválasztott vizsgálandó komponens egyidejűleg kötődik azelhasítható szignálelem első és második komponensspecifikusoldaltagjához, a szignálérzékeny csoport annak ellenére a szignálelemszubsztrátkapcsoló végéhez rögzül, hogy az első és második oldaltagközött elhelyezkedő hasítási hely elhasad. A szignálérzékeny csoportvisszaveri, elnyeli vagy megtöri a beeső lézerfényt. A leírás feltárnukleinsav-hibridizációs vizsgálati eljárásokat, nukleinsav-szekvenálást, immunvizsgálati eljárásokat, sejtszámlálási eljárásokatés kémiai detektálást is. A vizsgálati eszköz szubsztrát optikaihullámvezetőként történő működéshez való adaptálása folyamatos mérésrealkalmas vizsgálati geometriákat is lehetővé tesz. Ó
HU0103577A 1998-07-21 1999-07-20 Optikai lemez alapú eszközök és eljárások HUP0103577A2 (hu)

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US12004998A 1998-07-21 1998-07-21
PCT/US1999/012395 WO2000005582A2 (en) 1998-07-21 1999-07-20 Optical disc-based assay devices and methods

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Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US7094609B2 (en) 1996-09-20 2006-08-22 Burstein Technologies, Inc. Spatially addressable combinatorial chemical arrays in encoded optical disk format
KR20000075815A (ko) * 1997-02-28 2000-12-26 번스타인 리차드 디스크 내부 장치
US6320991B1 (en) 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
US7014815B1 (en) 1998-10-30 2006-03-21 Burstein Technologies, Inc. Trackable optical discs with concurrently readable nonoperational features
AU6075900A (en) * 1999-07-07 2001-01-22 Mirus Corporation Substrates for nucleic acid immobilization onto solid supports
US6602498B2 (en) 2000-02-22 2003-08-05 Shearwater Corporation N-maleimidyl polymer derivatives
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
DE10045419B4 (de) * 2000-09-14 2007-12-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung eines thermoelektrischen Bauelements, thermoelektrisches Bauelement sowie Vorrichtung zur Durchführung des Verfahrens
AU2002239779A1 (en) * 2000-10-27 2002-06-18 David P. Dumas Apparatus for light directed chemical synthesis
WO2002039446A2 (en) * 2000-11-09 2002-05-16 Burstein Technologies, Inc. Disc drive system and methods for use with bio-discs
WO2002047075A2 (en) * 2000-11-13 2002-06-13 Picoliter Inc. Integrated device with surface-attached molecular moieties and related machine-readable information
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
WO2002041004A2 (en) 2000-11-16 2002-05-23 Burstein Technologies, Inc. Optical biodiscs with reflective layers
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US20020196435A1 (en) * 2000-11-22 2002-12-26 Cohen David Samuel Apparatus and methods for separating agglutinants and disperse particles
AU2002216743A1 (en) * 2000-11-27 2002-06-03 Burstein Technologies, Inc. Dual bead assays including optical biodiscs and methods relating thereto
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
WO2002046721A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical discs for measuring analytes
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
US20020086294A1 (en) * 2000-12-29 2002-07-04 Ellson Richard N. Device and method for tracking conditions in an assay
WO2002095740A2 (en) * 2001-01-09 2002-11-28 Burstein Technologies, Inc. Methods and apparatus for analyzing operational and nonoperational data acquired from optical discs
WO2002056311A2 (en) * 2001-01-11 2002-07-18 Burstein Technologies Inc Optical disc analysis system including related methods for biological and medical imaging
WO2002068696A2 (en) * 2001-02-27 2002-09-06 Burstein Technologies, Inc. Methods for dna conjugation onto solid phase including related optical biodiscs and disc drive systems
WO2002068697A2 (en) * 2001-02-28 2002-09-06 Burstein Technologies, Inc. Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
WO2002073605A2 (en) * 2001-03-14 2002-09-19 Burstein Technologies, Inc. Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
EP1493014A2 (en) * 2001-04-11 2005-01-05 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
US7083920B2 (en) * 2001-05-18 2006-08-01 Nagaoka & Co. Ltd. Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US7141416B2 (en) 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US7221632B2 (en) 2001-07-12 2007-05-22 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
AU2002320642A1 (en) * 2001-07-19 2003-03-03 Burstein Technologies, Inc. Transmissive optical disc assemblies for performing physical measurements
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US7127066B2 (en) 2001-10-03 2006-10-24 Now Showing Entertainment, Inc. Limited use DVD-video disc
US6989891B2 (en) 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
AU2002360433A1 (en) * 2001-11-27 2003-06-10 Burstein Technologies, Inc. Magneto-optical bio-discs and systems including related methods
KR100845256B1 (ko) * 2001-12-24 2008-07-10 엘지디스플레이 주식회사 액정표시소자의 제조방법
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US20050002827A1 (en) * 2002-01-29 2005-01-06 Mcintyre Kevin Robert Optical discs including equi-radial and/or spiral analysis zones and related disc drive systems and methods
US7251210B2 (en) 2002-01-31 2007-07-31 Burstein Technologies, Inc. Method for triggering through disc grooves and related optical analysis discs and system
DE60230110D1 (de) * 2002-02-25 2009-01-15 St Microelectronics Srl Optisch lesbarer Molekularspeicher hergestellt mit Hilfe von Kohlenstoff-Nanoröhren und Verfahren zum Speichern von Information in diesem Molekularspeicher
JP3856214B2 (ja) * 2002-03-11 2006-12-13 横河電機株式会社 蛍光強度増強ビーズ
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
ATE444984T1 (de) 2002-12-31 2009-10-15 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
WO2004106925A2 (en) * 2003-03-03 2004-12-09 Nagaoka & Co.Ltd. Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same
AU2004297228A1 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
JP4621845B2 (ja) * 2004-07-12 2011-01-26 アークレイ株式会社 分析用具、分析用具における反応槽の特定方法および分析装置
US20060040273A1 (en) * 2004-08-17 2006-02-23 Alison Chaiken Method and apparatus for magnetic sensing and control of reagents
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7663092B2 (en) 2005-02-01 2010-02-16 Purdue Research Foundation Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay
US20060235348A1 (en) 2005-02-14 2006-10-19 Callicoat David N Method of extracting and analyzing the composition of bodily fluids
JP5192369B2 (ja) * 2005-03-10 2013-05-08 ロウステック プロプライエタリー リミテッド コンビナトリアル・ケミストリ用ディスク基板
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
JP4802309B2 (ja) * 2006-03-10 2011-10-26 国立大学法人 鹿児島大学 支持体に対する金属微粒子膜の形成方法及び局在プラズモン共鳴センサ
JP4670015B2 (ja) * 2006-05-02 2011-04-13 独立行政法人産業技術総合研究所 光検出型分子センサ及び分子検出方法
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US7659968B2 (en) 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
WO2008118934A1 (en) 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US8194514B2 (en) * 2008-02-29 2012-06-05 Simon Fraser University Methods for assessing the results of disc-based bioassays with standard computer optical drives
JP5344438B2 (ja) * 2008-03-26 2013-11-20 独立行政法人理化学研究所 物質固定用基板、物質固定化基板および分析方法
EP2318838B1 (en) * 2008-07-16 2013-09-04 Radiometer Medical ApS High capacity solid phase
US20100112558A1 (en) * 2008-11-03 2010-05-06 Xiaolian Gao Probe Bead Synthesis and Use
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
EP2456355B1 (en) 2009-07-20 2016-09-14 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
GB0913258D0 (en) * 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
EP3156796A1 (en) 2010-06-09 2017-04-19 Optiscan Biomedical Corporation Measuring analytes in a fluid sample drawn from a patient
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012158988A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for valving on a sample processing device
MX336625B (es) 2011-05-18 2016-01-26 3M Innovative Properties Co Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra.
WO2013006716A1 (en) 2011-07-06 2013-01-10 Optiscan Biomedical Corporation Sample cell for fluid analysis system
EP3650117B1 (en) * 2011-11-14 2022-07-20 Aushon Biosystems, Inc. Systems and methods to enhance consistency of assay performance
JP6019738B2 (ja) * 2012-05-16 2016-11-02 大日本印刷株式会社 親水性層を有する基材の製造方法
GB201217390D0 (en) 2012-09-28 2012-11-14 Agplus Diagnostics Ltd Test device and sample carrier
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US20180011089A1 (en) * 2015-02-02 2018-01-11 Koninklijke Philips N.V. Wearable with test strips and optical reader for skin
WO2017056526A1 (ja) 2015-09-30 2017-04-06 株式会社Ｊｖｃケンウッド 分析装置及び分析方法
US11331662B2 (en) 2017-09-29 2022-05-17 Miraplex Diagnostics Inc. Assay preparation device
JP7127512B2 (ja) 2018-11-28 2022-08-30 株式会社Ｊｖｃケンウッド 光ディスク装置及び光ディスク回転位置検出方法
US11498069B2 (en) * 2020-08-31 2022-11-15 International Business Machines Corporation Rapid testing device for wastewater analysis

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) * 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US3646346A (en) * 1968-12-26 1972-02-29 Pharmacia Ab Antibody-coated tube system for radioimmunoassay
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3817838A (en) * 1972-03-01 1974-06-18 Us Army Method of detecting and measuring lipase activity
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
GB1524372A (en) * 1975-01-09 1978-09-13 Radiochemical Centre Ltd Radioassay of oestrogens
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4037257A (en) * 1976-02-02 1977-07-19 Xerox Corporation Data clock separator with missing clock detect
US4160645A (en) * 1977-07-14 1979-07-10 Syva Company Catalyst mediated competitive protein binding assay
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4608344A (en) * 1981-09-18 1986-08-26 Battelle Memorial Institute Method for the determination of species in solution with an optical wave-guide
USRE33064E (en) * 1981-09-18 1989-09-19 Prutec Limited Method for the determination of species in solution with an optical wave-guide
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US5112134A (en) * 1984-03-01 1992-05-12 Molecular Devices Corporation Single source multi-site photometric measurement system
FI845161A0 (fi) * 1984-12-28 1984-12-28 Ksv Chemicals Oy Ytbehandlingsmedel.
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4877745A (en) * 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
EP0310361A3 (en) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Tridentate conjugate and method of use thereof
US5278048A (en) * 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5087556A (en) * 1989-05-17 1992-02-11 Actimed Laboratories, Inc. Method for quantitative analysis of body fluid constituents
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5334837A (en) * 1991-10-05 1994-08-02 Horiba, Ltd. Micro analytical method, sampling plate used in same, method of detecting organic compound by use of said micro analytical method, apparatus for same and method of dividing for micro-liquid flow
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5345213A (en) * 1992-10-26 1994-09-06 The United States Of America, As Represented By The Secretary Of Commerce Temperature-controlled, micromachined arrays for chemical sensor fabrication and operation
FR2705693B1 (fr) * 1993-05-24 1995-07-28 Neuchatel Universite Procédé de fabrication d'un dispositif micro-usiné à contenir ou à véhiculer un fluide.
US5429807A (en) * 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
JP3286721B2 (ja) * 1994-04-20 2002-05-27 株式会社リコー 光記録媒体及びその製造方法
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
DK0760944T3 (da) * 1994-05-27 2002-08-05 Novartis Ag Fremgangsmåde til påvisning af udklingende exciteret luminescens
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5599662A (en) * 1995-02-17 1997-02-04 Hoffmann-La Roche Inc. Oliconucleotide primers and probes for the detection of HIV-1
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
EP0918845A4 (en) * 1996-07-08 2000-08-30 Burstein Lab Inc METHOD AND APPARATUS WITH CLIVABLE SIGNAL ELEMENT
US7094609B2 (en) * 1996-09-20 2006-08-22 Burstein Technologies, Inc. Spatially addressable combinatorial chemical arrays in encoded optical disk format
PL335226A1 (en) * 1997-02-21 2000-04-10 Burstein Lab Gene sequencer and related methods
KR20000075815A (ko) * 1997-02-28 2000-12-26 번스타인 리차드 디스크 내부 장치

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