HUP0103064A2 - 5-Klór-4-[3-[N-[2-(3,4-dimetoxi-fenil)-etil)]-N-metil-amino]-[propilamino]-3-(2H)-piridazinon-fumarát polimorf só, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmény - Google Patents

5-Klór-4-[3-[N-[2-(3,4-dimetoxi-fenil)-etil)]-N-metil-amino]-[propilamino]-3-(2H)-piridazinon-fumarát polimorf só, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmény

Info

Publication number
HUP0103064A2
HUP0103064A2 HU0103064A HUP0103064A HUP0103064A2 HU P0103064 A2 HUP0103064 A2 HU P0103064A2 HU 0103064 A HU0103064 A HU 0103064A HU P0103064 A HUP0103064 A HU P0103064A HU P0103064 A2 HUP0103064 A2 HU P0103064A2
Authority
HU
Hungary
Prior art keywords
amino
dimethoxy
phenyl
ethyl
methyl
Prior art date
Application number
HU0103064A
Other languages
English (en)
Inventor
József Barkóczy
Nagy Péter Kótay
Gyula Simig
Királlyi Zsuzsa Szent
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0103064A priority Critical patent/HUP0103064A3/hu
Publication of HU0103064D0 publication Critical patent/HU0103064D0/hu
Priority to CNA028162587A priority patent/CN1545505A/zh
Priority to SK54-2004A priority patent/SK542004A3/sk
Priority to US10/484,621 priority patent/US20040266772A1/en
Priority to EA200400222A priority patent/EA200400222A1/ru
Priority to YU7604A priority patent/YU7604A/sh
Priority to CZ2004124A priority patent/CZ2004124A3/cs
Priority to PCT/HU2002/000076 priority patent/WO2003010150A1/en
Priority to PL02365483A priority patent/PL365483A1/xx
Priority to EP02755384A priority patent/EP1417179A1/en
Priority to CA002454774A priority patent/CA2454774A1/en
Priority to KR10-2004-7001150A priority patent/KR20040030861A/ko
Priority to JP2003515509A priority patent/JP2004536868A/ja
Priority to IL15996702A priority patent/IL159967A0/xx
Publication of HUP0103064A2 publication Critical patent/HUP0103064A2/hu
Priority to ZA200400483A priority patent/ZA200400483B/en
Publication of HUP0103064A3 publication Critical patent/HUP0103064A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

A találmány tárgya I. kristályformájú 5-klór-4-[3-[N-(2-(3,4-dimetoxi-fenil)-etil)]-N-metil-amino]-propil-amino]-3-(2H)-piridazinon-fumarát, amelynek CuKa sugárnál por alakban felvettröntgen-diffrakciós felvételének jellemző adatai az alábbiak:Diffrakciós vonalak helyzete és a relatív intenzitások (10 %)VERSION(8), COLUMNS(5), DIMENSION(TM),COLWIDTHS(187812,189036,172233,172233,176433), KEEP(OFF), ALIGN(LT),ABOVE(42333), BELOW(42333), HGUTTER(10584), BOX(Hidden),HGRID(Hidden), VGRID(Hidden), L1(R0C0..R1C0), L1(R0C1..R1C1),L1(R0C0..R0C1), L1(R1C0..R1C1), L1(R0C2..R1C2), L1(R0C1..R0C2),L1(R1C1..R1C2), L1(R0C3..R1C3), L1(R0C2..R0C3), L1(R1C2..R1C3),L1(R0C4..R1C4), L1(R0C3..R0C4), L1(R1C3..R1C4), L1(R0C5..R1C5),L1(R0C4..R0C5), L1(R1C4..R1C5), L1(R1C0..R2C0), L1(R1C1..R2C1),L1(R2C0..R2C1), L1(R1C2..R2C2), L1(R2C1..R2C2), L1(R1C3..R2C3),L1(R2C2..R2C3), L1(R1C4..R2C4), L1(R2C3..R2C4), L1(R1C5..R2C5),L1(R2C4..R2C5), L1(R2C0..R3C0), L1(R2C1..R3C1), L1(R3C0..R3C1),L1(R2C2..R3C2), L1(R3C1..R3C2), L1(R2C3..R3C3), L1(R3C2..R3C3),L1(R2C4..R3C4), L1(R3C3..R3C4), L1(R2C5..R3C5), L1(R3C4..R3C5),L1(R3C0..R4C0), L1(R3C1..R4C1), L1(R3C2..R4C2), L1(R3C3..R4C3),L1(R3C4..R4C4), L1(R3C5..R4C5), L1(R4C0..R5C0), L1(R4C1..R5C1),L1(R4C2..R5C2), L1(R4C3..R5C3), L1(R4C4..R5C4), L1(R4C5..R5C5),L1(R5C0..R6C0), L1(R5C1..R6C1), L1(R5C2..R6C2), L1(R5C3..R6C3),L1(R5C4..R6C4), L1(R5C5..R6C5), L1(R6C0..R7C0), L1(R6C1..R7C1),L1(R6C2..R7C2), L1(R6C3..R7C3), L1(R6C4..R7C4), L1(R6C5..R7C5),L1(R7C0..R8C0), L1(R7C1..R8C1), L1(R7C2..R8C2), L1(R7C3..R8C3),L1(R7C4..R8C4), L1(R7C5..R8C5), L1(R8C0..R9C0), L1(R8C1..R9C1),L1(R8C2..R9C2), L1(R8C3..R9C3), L1(R8C4..R9C4), L1(R8C5..R9C5),L1(R9C0..R10C0), L1(R9C1..R10C1), L1(R9C2..R10C2), L1(R9C3..R10C3),L1(R9C4..R10C4), L1(R9C5..R10C5), L1(R10C0..R11C0), L1(R10C1..R11C1),L1(R10C2..R11C2), L1(R10C3..R11C3), L1(R10C4..R11C4),L1(R10C5..R11C5), L1(R11C0..R12C0), L1(R11C1..R12C1),L1(R12C0..R12C1), L1(R11C2..R12C2), L1(R12C1..R12C2),L1(R11C3..R12C3), L1(R12C2..R12C3), L1(R11C4..R12C4),L1(R12C3..R12C4), L1(R11C5..R12C5), L1(R12C4..R12C5),L1(R12C0..R13C0), L1(R12C1..R13C1), L1(R13C0..R13C1),L1(R12C2..R13C2), L1(R13C1..R13C2), L1(R12C3..R13C3),L1(R13C2..R13C3), L1(R12C4..R13C4), L1(R13C3..R13C4),L1(R12C5..R13C5), L1(R13C4..R13C5), L1(R13C0..R14C0),L1(R13C1..R14C1), L1(R14C0..R14C1), L1(R13C2..R14C2),L1(R14C1..R14C2), L1(R13C3..R14C3), L1(R14C2..R14C3),L1(R13C4..R14C4), L1(R14C3..R14C4), L1(R13C5..R14C5),L1(R14C4..R14C5), L1(R14C0..R15C0), L1(R14C1..R15C1),L1(R15C0..R15C1), L1(R14C2..R15C2), L1(R15C1..R15C2)
HU0103064A 2001-07-26 2001-07-26 Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it HUP0103064A3 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
HU0103064A HUP0103064A3 (en) 2001-07-26 2001-07-26 Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it
IL15996702A IL159967A0 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment of arrythmia
CZ2004124A CZ2004124A3 (cs) 2001-07-26 2002-07-26 Název neuveden
PL02365483A PL365483A1 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment of arrythmia
US10/484,621 US20040266772A1 (en) 2001-07-26 2002-07-26 Polymorph salt of a pryridazinone derivative for the treatment of arrythmia
EA200400222A EA200400222A1 (ru) 2001-07-26 2002-07-26 Полиморфная соль производного пиридазинона для лечения аритмии
YU7604A YU7604A (sh) 2001-07-26 2002-07-26 Polimorf soli derivata piridazinona za tretman aritmije
CNA028162587A CN1545505A (zh) 2001-07-26 2002-07-26 用于治疗心律失常的哒嗪酮衍生物的多晶型盐
PCT/HU2002/000076 WO2003010150A1 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment of arrythmia
SK54-2004A SK542004A3 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment arrhythmia
EP02755384A EP1417179A1 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment of arrhythmia
CA002454774A CA2454774A1 (en) 2001-07-26 2002-07-26 Polymorph salt of a pyridazinone derivative for the treatment of arrythmia
KR10-2004-7001150A KR20040030861A (ko) 2001-07-26 2002-07-26 부정맥 치료용의 피리다지논 유도체의 다형 염
JP2003515509A JP2004536868A (ja) 2001-07-26 2002-07-26 不整脈治療用のピリダジノン誘導体の多形体塩
ZA200400483A ZA200400483B (en) 2001-07-26 2004-01-22 Polymorph salt of a pyridazinone derivative for the treatment of arrythmia.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0103064A HUP0103064A3 (en) 2001-07-26 2001-07-26 Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it

Publications (3)

Publication Number Publication Date
HU0103064D0 HU0103064D0 (en) 2001-10-28
HUP0103064A2 true HUP0103064A2 (hu) 2003-02-28
HUP0103064A3 HUP0103064A3 (en) 2005-06-28

Family

ID=89979563

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103064A HUP0103064A3 (en) 2001-07-26 2001-07-26 Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it

Country Status (15)

Country Link
US (1) US20040266772A1 (hu)
EP (1) EP1417179A1 (hu)
JP (1) JP2004536868A (hu)
KR (1) KR20040030861A (hu)
CN (1) CN1545505A (hu)
CA (1) CA2454774A1 (hu)
CZ (1) CZ2004124A3 (hu)
EA (1) EA200400222A1 (hu)
HU (1) HUP0103064A3 (hu)
IL (1) IL159967A0 (hu)
PL (1) PL365483A1 (hu)
SK (1) SK542004A3 (hu)
WO (1) WO2003010150A1 (hu)
YU (1) YU7604A (hu)
ZA (1) ZA200400483B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227181B1 (en) * 2002-09-11 2010-09-28 Egis Gyogyszergyar Nyilvanosan Use of 5-chloro-4-[3-[n-[2-(3,4-dimethoxyphenyl)ethyl)]-n-methylamino]-propylamino]-3-(2h)-pyridazinone for producing pharmaceutical compositions having metabolic modulator effect
HU227115B1 (en) * 2003-10-10 2010-07-28 Egis Gyogyszergyar Nyilvanosan Pellets containing pyridazinone derivative
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
CA2334220A1 (en) * 1998-06-05 1999-12-16 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative

Also Published As

Publication number Publication date
EP1417179A1 (en) 2004-05-12
SK542004A3 (en) 2004-08-03
YU7604A (sh) 2006-08-17
WO2003010150A1 (en) 2003-02-06
PL365483A1 (en) 2005-01-10
ZA200400483B (en) 2005-04-22
JP2004536868A (ja) 2004-12-09
HU0103064D0 (en) 2001-10-28
CN1545505A (zh) 2004-11-10
CZ2004124A3 (cs) 2004-06-16
US20040266772A1 (en) 2004-12-30
EA200400222A1 (ru) 2004-12-30
IL159967A0 (en) 2004-06-20
KR20040030861A (ko) 2004-04-09
CA2454774A1 (en) 2003-02-06
HUP0103064A3 (en) 2005-06-28

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Legal Events

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HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished