HUP0102321A2 - Szinaptikus válaszokat fokozó hatású acil-benzoxazinok és alkalmazásuk - Google Patents
Szinaptikus válaszokat fokozó hatású acil-benzoxazinok és alkalmazásukInfo
- Publication number
- HUP0102321A2 HUP0102321A2 HU0102321A HUP0102321A HUP0102321A2 HU P0102321 A2 HUP0102321 A2 HU P0102321A2 HU 0102321 A HU0102321 A HU 0102321A HU P0102321 A HUP0102321 A HU P0102321A HU P0102321 A2 HUP0102321 A2 HU P0102321A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- formula
- compounds
- treatment
- subjects
- Prior art date
Links
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 230000009782 synaptic response Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000003678 AMPA Receptors Human genes 0.000 abstract 3
- 108090000078 AMPA Receptors Proteins 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 abstract 1
- YXTROGRGRSPWKL-UHFFFAOYSA-N 1-benzoylpiperidine Chemical class C=1C=CC=CC=1C(=O)N1CCCCC1 YXTROGRGRSPWKL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000036992 cognitive tasks Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002964 excitative effect Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány (I) általános képletű acilbenzoxazin-vegyületekre - aképletben R1 és R2 jelentése azonosan vagy eltérően H, CH2OR4 vagyOR4, azzal a megkötéssel, hogy R1 és R2 közül legalább az egyikjelentése hidrogénatomtól eltérő; vagy R1 és R2 együtt (a), (b), (c),(d), (e), (f), (g) vagy (h) képletű csoportot alkot; R3 jelentése H,1-6 szénatomos alkilcsoport vagy 1-6 szénatomos fluoralkilcsoport; Qjelentése szubsztituált vagy szubsztituálatlan rövid szénláncúalkiléncsoport, cikloalkilcsoport, arilcsoport, arilalkilcsoport vagyheteroarilalkilcsoport; X és Y jelentése egymástól függetlenül H, vagyegyüttes jelentésük kovalens kötés vagy (CH2)n, amely a Q csoportot abenzoxazin-gyűrűhöz kapcsolja; m értéke 1 vagy 2, és n értéke 1 vagy 2-vonatkozik, amelyek jelentősen nagyobb hatást fejtenek ki az AMPA-receptorok által mediált szinaptikus válaszok növelésére, mint amegfelelő benzoil-piperidinek. Ismertetik a fenti vegyületekelőállítására szolgáló eljárásokat, valamint a fenti vegyületekalkalmazását AMPA-receptorok vagy izgalmi szinapszisok csökkentszámának tulajdonítható kóros idegműködésű vagy csökkentintellektuális képességű alanyok kezelésére. A találmány szerintivegyületek alkalmasak továbbá nem beteg alanyok kezelésére is aszenzoros-motoros és megismerési feladatokkal kapcsolatos teljesítményjavítására, amelyek az AMPA-receptorokat alkalmazó agyi hálózattólfüggnek, és a memória kódolás javítására. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/054,916 US6124278A (en) | 1998-04-03 | 1998-04-03 | Acylbenzoxazines for enhancing synaptic response |
| PCT/US1999/007325 WO1999051240A1 (en) | 1998-04-03 | 1999-04-02 | Acylbenzoxazines for enhancing synaptic response(s) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102321A2 true HUP0102321A2 (hu) | 2001-11-28 |
| HUP0102321A3 HUP0102321A3 (en) | 2002-01-28 |
Family
ID=21994357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102321A HUP0102321A3 (en) | 1998-04-03 | 1999-04-02 | Acylbenzoxazines for enhancing synaptic response(s) and their use |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6124278A (hu) |
| EP (1) | EP1067935B1 (hu) |
| JP (1) | JP4574846B2 (hu) |
| KR (1) | KR100646753B1 (hu) |
| CN (1) | CN1186020C (hu) |
| AT (1) | ATE247472T1 (hu) |
| AU (1) | AU736376B2 (hu) |
| BR (1) | BR9909378A (hu) |
| CA (1) | CA2326764C (hu) |
| CZ (1) | CZ292931B6 (hu) |
| DE (1) | DE69910552T2 (hu) |
| DK (1) | DK1067935T3 (hu) |
| ES (1) | ES2207194T3 (hu) |
| HK (1) | HK1039060B (hu) |
| HU (1) | HUP0102321A3 (hu) |
| IL (1) | IL138284A0 (hu) |
| NO (1) | NO20004383L (hu) |
| NZ (1) | NZ506712A (hu) |
| PL (1) | PL195394B1 (hu) |
| PT (1) | PT1067935E (hu) |
| RU (1) | RU2246498C2 (hu) |
| TR (1) | TR200002849T2 (hu) |
| WO (1) | WO1999051240A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
| MXPA03011562A (es) | 2001-06-14 | 2004-03-18 | Akzo Nobel Nv | Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. |
| AU2002352886B2 (en) * | 2001-11-26 | 2008-10-16 | Cortex Pharmaceuticals, Inc. | Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses |
| US20110104716A1 (en) * | 2003-08-08 | 2011-05-05 | Hasan Mohejeri | Novel method for screening brain-active compounds |
| TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
| CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| UA104002C2 (ru) * | 2008-06-06 | 2013-12-25 | Санофи-Авентис | МАКРОЦИКЛИЧЕСКИЕ ПРОИЗВОДНЫЕ МОЧЕВИНЫ И СУЛЬФАМИДА КАК ИНГИБИТОРЫ TAFIa |
| WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| AU2014277952A1 (en) | 2013-06-13 | 2016-01-28 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
| CN108689876B (zh) * | 2018-06-28 | 2020-11-27 | 苏州东南药业股份有限公司 | 一种8-(2-羟基苯甲酰胺基)辛酸钠的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0475908A1 (de) * | 1990-09-14 | 1992-03-18 | Ciba-Geigy Ag | Chromogene Lactamverbindungen und ihre Herstellung und Verwendung |
| CA2138533C (en) * | 1992-07-24 | 2009-04-14 | Gary S. Lynch | Drugs that enhance synaptic responses mediated by ampa receptors |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
-
1998
- 1998-04-03 US US09/054,916 patent/US6124278A/en not_active Expired - Lifetime
-
1999
- 1999-04-02 KR KR1020007010679A patent/KR100646753B1/ko not_active IP Right Cessation
- 1999-04-02 AU AU33798/99A patent/AU736376B2/en not_active Ceased
- 1999-04-02 EP EP99915240A patent/EP1067935B1/en not_active Expired - Lifetime
- 1999-04-02 RU RU2000127738/04A patent/RU2246498C2/ru not_active IP Right Cessation
- 1999-04-02 CZ CZ20003614A patent/CZ292931B6/cs not_active IP Right Cessation
- 1999-04-02 NZ NZ506712A patent/NZ506712A/xx unknown
- 1999-04-02 HU HU0102321A patent/HUP0102321A3/hu unknown
- 1999-04-02 TR TR2000/02849T patent/TR200002849T2/xx unknown
- 1999-04-02 IL IL13828499A patent/IL138284A0/xx not_active IP Right Cessation
- 1999-04-02 PT PT99915240T patent/PT1067935E/pt unknown
- 1999-04-02 WO PCT/US1999/007325 patent/WO1999051240A1/en not_active Application Discontinuation
- 1999-04-02 AT AT99915240T patent/ATE247472T1/de active
- 1999-04-02 ES ES99915240T patent/ES2207194T3/es not_active Expired - Lifetime
- 1999-04-02 DK DK99915240T patent/DK1067935T3/da active
- 1999-04-02 CN CNB998046949A patent/CN1186020C/zh not_active Expired - Fee Related
- 1999-04-02 CA CA2326764A patent/CA2326764C/en not_active Expired - Fee Related
- 1999-04-02 DE DE69910552T patent/DE69910552T2/de not_active Expired - Lifetime
- 1999-04-02 JP JP2000542011A patent/JP4574846B2/ja not_active Expired - Fee Related
- 1999-04-02 PL PL99345687A patent/PL195394B1/pl not_active IP Right Cessation
- 1999-04-02 BR BR9909378-2A patent/BR9909378A/pt not_active Application Discontinuation
-
2000
- 2000-09-04 NO NO20004383A patent/NO20004383L/no not_active Application Discontinuation
-
2002
- 2002-01-11 HK HK02100196.0A patent/HK1039060B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |