HUP0101281A3 - Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing them - Google Patents
Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing themInfo
- Publication number
- HUP0101281A3 HUP0101281A3 HU0101281A HUP0101281A HUP0101281A3 HU P0101281 A3 HUP0101281 A3 HU P0101281A3 HU 0101281 A HU0101281 A HU 0101281A HU P0101281 A HUP0101281 A HU P0101281A HU P0101281 A3 HUP0101281 A3 HU P0101281A3
- Authority
- HU
- Hungary
- Prior art keywords
- producing
- butanamides
- piperidine
- diphenyl
- pharmaceutical compositions
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- -1 Diphenyl-piperidine butanamides Chemical class 0.000 title 1
- 239000004471 Glycine Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98200700 | 1998-03-06 | ||
PCT/EP1999/001308 WO1999045011A1 (en) | 1998-03-06 | 1999-02-26 | Glycine transport inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101281A2 HUP0101281A2 (hu) | 2001-09-28 |
HUP0101281A3 true HUP0101281A3 (en) | 2001-11-28 |
Family
ID=8233443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101281A HUP0101281A3 (en) | 1998-03-06 | 1999-02-26 | Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1058684A1 (hu) |
JP (1) | JP2002505332A (hu) |
KR (1) | KR20010032967A (hu) |
CN (1) | CN1291984A (hu) |
AU (1) | AU3254499A (hu) |
BG (1) | BG104686A (hu) |
BR (1) | BR9907953A (hu) |
CA (1) | CA2322136A1 (hu) |
EE (1) | EE200000483A (hu) |
HR (1) | HRP20000524A2 (hu) |
HU (1) | HUP0101281A3 (hu) |
IL (1) | IL138227A0 (hu) |
NO (1) | NO20004432L (hu) |
PL (1) | PL342818A1 (hu) |
SK (1) | SK13092000A3 (hu) |
TR (1) | TR200002570T2 (hu) |
WO (1) | WO1999045011A1 (hu) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA73749C2 (en) * | 1999-11-01 | 2005-09-15 | Diarylenines | |
JP2004508312A (ja) | 2000-09-08 | 2004-03-18 | グリアテック インコーポレイテッド | 置換ヒドラジン誘導体 |
AU2001290786A1 (en) * | 2000-09-14 | 2002-03-26 | Gliatech, Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
KR20030043970A (ko) * | 2000-10-12 | 2003-06-02 | 에스에스 세야쿠 가부시키 가이샤 | 2,2-디페닐부탄아미드 유도체 및 이를 함유하는 의약 |
AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
JPWO2003082819A1 (ja) * | 2002-04-01 | 2005-08-04 | 日本ケミファ株式会社 | N−フェニル−n−(4−ピペリジニル)アミド誘導体 |
FR2838739B1 (fr) | 2002-04-19 | 2004-05-28 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
FR2842805A1 (fr) * | 2002-07-29 | 2004-01-30 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide,leur preparation et leur application et therapeutique |
US7202259B2 (en) | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
WO2004072034A1 (en) | 2003-02-17 | 2004-08-26 | F. Hoffmann-La Roche Ag | Piperidine-benzenesulfonamide derivatives |
KR100774622B1 (ko) | 2003-08-11 | 2007-11-08 | 에프. 호프만-라 로슈 아게 | Or-치환된 페닐 그룹을 갖는 피페라진 및 glyt1억제제로서 그의 용도 |
FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
FR2861070B1 (fr) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique |
FR2861076B1 (fr) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
WO2005058317A1 (en) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Glycine transporter-1 inhibirors |
CA2552087C (en) | 2004-01-30 | 2011-01-25 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
GB0408774D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
ATE430142T1 (de) | 2004-12-09 | 2009-05-15 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
ATE457989T1 (de) | 2004-12-15 | 2010-03-15 | Hoffmann La Roche | Bi- und trizyklische substituierte phenyl- methanone als inhibitoren von glycin-i (glyt-1)- transportern zur behandlung der alzheimer- krankheit |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
ATE472327T1 (de) | 2005-01-07 | 2010-07-15 | Hoffmann La Roche | Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen |
AU2006207650B2 (en) | 2005-01-18 | 2011-01-27 | F. Hoffmann-La Roche Ag | 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders |
AU2006208547B2 (en) | 2005-01-26 | 2011-02-10 | F. Hoffmann-La Roche Ag | Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors |
ES2334578T3 (es) | 2005-02-07 | 2010-03-12 | F. Hoffmann-La Roche Ag | Fenil-metanonas sustituidas por heterociclo como inhibidores del transportador 1 de la glicina. |
UA88518C2 (ru) | 2005-04-08 | 2009-10-26 | Пфайзер Продактс Инк. | Бицикло[3,1,0]гетероариламиды как ингибиторы транспорта глицина типа i |
WO2009010479A2 (en) * | 2007-07-13 | 2009-01-22 | Euroscreen S.A. | Heterocyclic methylene piperidine derivatives and their use |
BRPI0922787A2 (pt) * | 2008-12-04 | 2017-07-11 | Sanofi Sa | Formas polimórficas de um derivado da azabiciclo-trifluorometil benzamida |
CN102766080B (zh) * | 2011-05-06 | 2015-09-23 | 上海医药工业研究院 | 一类吡咯烷衍生物、其制备方法及应用 |
KR20130002292A (ko) * | 2011-06-28 | 2013-01-07 | 주식회사 비보존 | 다중 타겟팅의 상승 효과를 유발하는 유효물질의 조합 및 그 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3714159A (en) * | 1971-03-30 | 1973-01-30 | Janssen Pharmaceutica Nv | 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
CA1332236C (en) * | 1985-10-11 | 1994-10-04 | Lourens Wals | ,--diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, n-oxides |
JP4403212B2 (ja) * | 1996-05-31 | 2010-01-27 | エヌピーエス ファーマシューティカルズ インコーポレイテッド | 神経障害および神経心理学的障害の治療のための製剤学的薬剤 |
-
1999
- 1999-02-26 KR KR1020007006314A patent/KR20010032967A/ko not_active Application Discontinuation
- 1999-02-26 IL IL138227??A patent/IL138227A0/xx unknown
- 1999-02-26 BR BR9907953-4A patent/BR9907953A/pt not_active Application Discontinuation
- 1999-02-26 AU AU32544/99A patent/AU3254499A/en not_active Abandoned
- 1999-02-26 EP EP99937930A patent/EP1058684A1/en not_active Withdrawn
- 1999-02-26 JP JP2000534553A patent/JP2002505332A/ja not_active Withdrawn
- 1999-02-26 WO PCT/EP1999/001308 patent/WO1999045011A1/en not_active Application Discontinuation
- 1999-02-26 SK SK1309-2000A patent/SK13092000A3/sk unknown
- 1999-02-26 CA CA002322136A patent/CA2322136A1/en not_active Abandoned
- 1999-02-26 PL PL99342818A patent/PL342818A1/xx unknown
- 1999-02-26 CN CN99803530A patent/CN1291984A/zh active Pending
- 1999-02-26 EE EEP200000483A patent/EE200000483A/xx unknown
- 1999-02-26 HU HU0101281A patent/HUP0101281A3/hu unknown
- 1999-02-26 TR TR2000/02570T patent/TR200002570T2/xx unknown
-
2000
- 2000-08-02 HR HR20000524A patent/HRP20000524A2/hr not_active Application Discontinuation
- 2000-08-11 BG BG104686A patent/BG104686A/xx unknown
- 2000-09-05 NO NO20004432A patent/NO20004432L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1291984A (zh) | 2001-04-18 |
IL138227A0 (en) | 2001-10-31 |
TR200002570T2 (tr) | 2000-12-21 |
CA2322136A1 (en) | 1999-09-10 |
NO20004432D0 (no) | 2000-09-05 |
WO1999045011A1 (en) | 1999-09-10 |
NO20004432L (no) | 2000-11-02 |
JP2002505332A (ja) | 2002-02-19 |
AU3254499A (en) | 1999-09-20 |
SK13092000A3 (sk) | 2001-03-12 |
BG104686A (en) | 2001-04-30 |
BR9907953A (pt) | 2000-10-24 |
HUP0101281A2 (hu) | 2001-09-28 |
EE200000483A (et) | 2002-02-15 |
WO1999045011A8 (en) | 1999-10-14 |
KR20010032967A (ko) | 2001-04-25 |
PL342818A1 (en) | 2001-07-02 |
EP1058684A1 (en) | 2000-12-13 |
HRP20000524A2 (en) | 2001-02-28 |
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