WO1999045011A8 - Glycine transport inhibitors - Google Patents

Glycine transport inhibitors

Info

Publication number
WO1999045011A8
WO1999045011A8 PCT/EP1999/001308 EP9901308W WO9945011A8 WO 1999045011 A8 WO1999045011 A8 WO 1999045011A8 EP 9901308 W EP9901308 W EP 9901308W WO 9945011 A8 WO9945011 A8 WO 9945011A8
Authority
WO
WIPO (PCT)
Prior art keywords
glycine transport
transport inhibitors
preparation
piperidinebutanamides
epilepsy
Prior art date
Application number
PCT/EP1999/001308
Other languages
French (fr)
Other versions
WO1999045011A1 (en
Inventor
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002322136A priority Critical patent/CA2322136A1/en
Priority to SK1309-2000A priority patent/SK13092000A3/en
Application filed by Janssen Pharmaceutica Nv, Walter Herman Maria Lou Luyten, Frans Eduard Janssens, Ludo Edmond Josephine Kennis filed Critical Janssen Pharmaceutica Nv
Priority to JP2000534553A priority patent/JP2002505332A/en
Priority to BR9907953-4A priority patent/BR9907953A/en
Priority to EEP200000483A priority patent/EE200000483A/en
Priority to HU0101281A priority patent/HUP0101281A3/en
Priority to PL99342818A priority patent/PL342818A1/en
Priority to KR1020007006314A priority patent/KR20010032967A/en
Priority to AU32544/99A priority patent/AU3254499A/en
Priority to IL138227??A priority patent/IL138227A0/en
Priority to EP99937930A priority patent/EP1058684A1/en
Publication of WO1999045011A1 publication Critical patent/WO1999045011A1/en
Publication of WO1999045011A8 publication Critical patent/WO1999045011A8/en
Priority to HR20000524A priority patent/HRP20000524A2/en
Priority to BG104686A priority patent/BG104686A/en
Priority to NO20004432A priority patent/NO20004432L/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

The present invention is concerned with the use of glycine transport inhibiting α,α-diphenyl-1-piperidinebutanamides for the preparation of medicaments for treating disorders of the central and peripheral nervous system, in particular psychoses, pain, epilepsy, neurodegenerative diseases (Alzheimer's disease), stroke, head trauma, multiple sclerosis and the like. The invention further comprises novel compounds, their preparation and their pharmaceutical forms.
PCT/EP1999/001308 1998-03-06 1999-02-26 Glycine transport inhibitors WO1999045011A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU32544/99A AU3254499A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
KR1020007006314A KR20010032967A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
JP2000534553A JP2002505332A (en) 1998-03-06 1999-02-26 Glycine transport inhibitor
SK1309-2000A SK13092000A3 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
EEP200000483A EE200000483A (en) 1998-03-06 1999-02-26 Use of a Glycine Transfer Inhibitory Compound in the manufacture of a medicament, a compound, a composition comprising it, and a process for the preparation of the compound and
HU0101281A HUP0101281A3 (en) 1998-03-06 1999-02-26 Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing them
IL138227??A IL138227A0 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
CA002322136A CA2322136A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
BR9907953-4A BR9907953A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
PL99342818A PL342818A1 (en) 1998-03-06 1999-02-26 Glycin transport inhibitors
EP99937930A EP1058684A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
HR20000524A HRP20000524A2 (en) 1998-03-06 2000-08-02 Gylcine transport inhibitors
BG104686A BG104686A (en) 1998-03-06 2000-08-11 Glycine transport inhibitors
NO20004432A NO20004432L (en) 1998-03-06 2000-09-05 Glysintransportinhibitorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200700 1998-03-06
EP98200700.7 1998-03-06

Publications (2)

Publication Number Publication Date
WO1999045011A1 WO1999045011A1 (en) 1999-09-10
WO1999045011A8 true WO1999045011A8 (en) 1999-10-14

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KR (1) KR20010032967A (en)
CN (1) CN1291984A (en)
AU (1) AU3254499A (en)
BG (1) BG104686A (en)
BR (1) BR9907953A (en)
CA (1) CA2322136A1 (en)
EE (1) EE200000483A (en)
HR (1) HRP20000524A2 (en)
HU (1) HUP0101281A3 (en)
IL (1) IL138227A0 (en)
NO (1) NO20004432L (en)
PL (1) PL342818A1 (en)
SK (1) SK13092000A3 (en)
TR (1) TR200002570T2 (en)
WO (1) WO1999045011A1 (en)

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EP1324986A1 (en) * 2000-09-14 2003-07-09 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AU2001294240A1 (en) * 2000-10-12 2002-04-22 Ssp Co., Ltd. 2,2-diphenylbutanamide derivatives and medicines containing the same
AR032653A1 (en) 2001-02-09 2003-11-19 Telik Inc HYPERCYCLIC INHIBITORS OF THE GLICINE TRANSPORTER 2 PHARMACEUTICAL COMPOSITIONS, USE AND METHODS.
WO2003082819A1 (en) * 2002-04-01 2003-10-09 Nippon Chemiphar Co.,Ltd. N-phenyl-n-(4-piperidinyl)amide derivative
FR2838739B1 (en) * 2002-04-19 2004-05-28 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL) BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
FR2842804B1 (en) * 2002-07-29 2004-09-03 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2842805A1 (en) * 2002-07-29 2004-01-30 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND APPLICATION THERAPEUTICS
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
JP4368375B2 (en) 2003-02-17 2009-11-18 エフ．ホフマン−ラ ロシュ アーゲー Piperidine-benzenesulfonamide derivatives
RS53252B (en) * 2003-08-11 2014-08-29 F.Hoffmann-La Roche Ag. Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors
FR2861076B1 (en) 2003-10-17 2006-01-06 Sanofi Synthelabo N-HETEROCYCLYMETHYLBENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861071B1 (en) 2003-10-17 2006-01-06 Sanofi Synthelabo N- [PHENYL (ALKYLPIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861070B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo DERIVATIVES OF N- [PHENYL (PYRROLIDIN-2-YL) METHYL] BENZAMIDE AND N - [(AZEPAN-2-YL) PHENYLMETHYL] BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
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JP4709849B2 (en) * 2004-12-15 2011-06-29 エフ．ホフマン−ラ ロシュ アーゲー Bicyclic and tricyclic substituted phenylmethanones as glycine transporter I (GLYT-1) inhibitors for the treatment of Alzheimer's disease
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
KR100895752B1 (en) 2005-01-07 2009-04-30 에프. 호프만-라 로슈 아게 [4-heteroarylpiperazin-1-yl]-2,5-substituted-phenylmethanone derivatives as glycine transporter 1glyt-1 inhibitors for the treatment of neurological and neuropsychiatric disorders
CN101141959B (en) 2005-01-18 2010-12-15 弗·哈夫曼-拉罗切有限公司 2,5-disubstituted phenyl methanone derivatives as glycine transporter 1 (Glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
CA2595605A1 (en) 2005-01-26 2006-08-03 F. Hoffmann-La Roche Ag Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors
MX2007009342A (en) 2005-02-07 2007-09-21 Hoffmann La Roche Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1.
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AU3254499A (en) 1999-09-20
EE200000483A (en) 2002-02-15
HUP0101281A2 (en) 2001-09-28
SK13092000A3 (en) 2001-03-12
BR9907953A (en) 2000-10-24
BG104686A (en) 2001-04-30
PL342818A1 (en) 2001-07-02
CN1291984A (en) 2001-04-18
HRP20000524A2 (en) 2001-02-28
HUP0101281A3 (en) 2001-11-28
CA2322136A1 (en) 1999-09-10
EP1058684A1 (en) 2000-12-13
KR20010032967A (en) 2001-04-25
TR200002570T2 (en) 2000-12-21
WO1999045011A1 (en) 1999-09-10
NO20004432D0 (en) 2000-09-05
IL138227A0 (en) 2001-10-31
JP2002505332A (en) 2002-02-19
NO20004432L (en) 2000-11-02

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