HUP0003958A2 - Eljárás 4-aril-piperidinek előállítására és az eljárásban alkalmazott intermedierek - Google Patents

Eljárás 4-aril-piperidinek előállítására és az eljárásban alkalmazott intermedierek

Info

Publication number
HUP0003958A2
HUP0003958A2 HU0003958A HUP0003958A HUP0003958A2 HU P0003958 A2 HUP0003958 A2 HU P0003958A2 HU 0003958 A HU0003958 A HU 0003958A HU P0003958 A HUP0003958 A HU P0003958A HU P0003958 A2 HUP0003958 A2 HU P0003958A2
Authority
HU
Hungary
Prior art keywords
aryl
piperidines
methylenedioxy
general formula
phenyl group
Prior art date
Application number
HU0003958A
Other languages
English (en)
Inventor
Victor Witold Jacewicz
Evgeny Shapiro
Marvin Sungwhan Yu
Original Assignee
Smithkline Beecham Corporation
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9711095.1A external-priority patent/GB9711095D0/en
Priority claimed from GBGB9714875.3A external-priority patent/GB9714875D0/en
Application filed by Smithkline Beecham Corporation, Smithkline Beecham P.L.C. filed Critical Smithkline Beecham Corporation
Publication of HUP0003958A2 publication Critical patent/HUP0003958A2/hu
Publication of HUP0003958A3 publication Critical patent/HUP0003958A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya eljárás (1) általános képletű 4-aril-piperidinek - amelyek képletében R hidrogénatom, alkil-, aralkil-, aril-, acil-,alkoxi-karbonil-, (aril-alkoxi)-karbonil-csoport, és Z' 3,4-(metilén-dioxi)-fenil-csoport - előállítására, amelynek során egy (2a) vagy(2b) általános képletű vegyületet - amelyek képletében Y oxigén- vagy kénatom, R és X a fentiekbenmeghatározott, és Z hidrogénatom, alkil-, aralkil- vagy arilcsoport -redukálnak, majd ahol Z 3,4-(metilén-dioxi)-fenil-csoporttól eltérő, aZ szubsztituenst 3,4-(metilén-dioxi)-fenil-csoporttá alakítják át. Az(1) általános képletű vegyületek depresszióellenes és Parkinson-kór-ellenes hatással rendelkeznek. Ó
HU0003958A 1997-05-29 1998-05-29 Process for preparation of 4-aryl-piperidines and intermediates HUP0003958A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9711095.1A GB9711095D0 (en) 1997-05-29 1997-05-29 Novel process
GBGB9714875.3A GB9714875D0 (en) 1997-07-15 1997-07-15 Novel process
PCT/US1998/011057 WO1998053824A1 (en) 1997-05-29 1998-05-29 Novel process

Publications (2)

Publication Number Publication Date
HUP0003958A2 true HUP0003958A2 (hu) 2001-05-28
HUP0003958A3 HUP0003958A3 (en) 2001-06-28

Family

ID=26311618

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003958A HUP0003958A3 (en) 1997-05-29 1998-05-29 Process for preparation of 4-aryl-piperidines and intermediates

Country Status (22)

Country Link
US (3) US6489347B1 (hu)
EP (1) EP0986389B1 (hu)
JP (1) JP2002514222A (hu)
CN (1) CN1268889A (hu)
AP (1) AP9901698A0 (hu)
AT (1) ATE279393T1 (hu)
AU (1) AU7708998A (hu)
BG (1) BG104034A (hu)
BR (1) BR9809687A (hu)
CA (1) CA2291251A1 (hu)
DE (1) DE69827000D1 (hu)
EA (1) EA199901098A1 (hu)
HU (1) HUP0003958A3 (hu)
ID (1) ID24383A (hu)
IL (1) IL133140A0 (hu)
NO (1) NO995796D0 (hu)
NZ (1) NZ501285A (hu)
OA (1) OA11223A (hu)
PL (1) PL337513A1 (hu)
SK (1) SK159899A3 (hu)
TR (1) TR199902929T2 (hu)
WO (1) WO1998053824A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6438585B2 (en) * 1998-05-29 2002-08-20 Research In Motion Limited System and method for redirecting message attachments between a host system and a mobile data communication device
WO2000026187A1 (en) * 1998-11-02 2000-05-11 Synthon B.V. Process for producing 4-arylpiperidine-3-carbinols and related compounds
US20010053862A1 (en) * 1998-12-22 2001-12-20 Bruce Ronsen Process for preparing arylpiperidine carbinol intermediates and derivatives
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
US6833458B2 (en) * 2000-06-05 2004-12-21 Development Center For Biotechnology Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
JP2004520333A (ja) 2001-01-04 2004-07-08 フエルレル インターナショナル，ソシエダッド アノニマ （±）−トランス−４−ｐ−フルオロフェニル−３−ヒドロキシメチル−１−メチルピペリジンの製造方法。
CA2464327A1 (en) 2001-10-22 2003-05-30 Synthon B.V. N-formyl derivatives of paroxetine
US20080033050A1 (en) * 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
CN112645951A (zh) * 2020-12-23 2021-04-13 上海博栋化学科技有限公司 由长春布宁合成的磺酸锍盐类光产酸剂及其合成方法

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US2798432A (en) * 1945-02-27 1957-07-09 Leo T Meister Delay action fuse
US2498432A (en) 1946-07-08 1950-02-21 Hoffmann La Roche 1-branched lower alkyl-4-phenyl-4-acyloxy-piperidines and their acid addition salts
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4585777A (en) 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
US4593036A (en) 1984-02-07 1986-06-03 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator
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ATE242213T1 (de) 1995-09-07 2003-06-15 Hoffmann La Roche Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz
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Also Published As

Publication number Publication date
EP0986389A4 (en) 2001-09-12
US20020133011A1 (en) 2002-09-19
DE69827000D1 (de) 2004-11-18
US6716985B2 (en) 2004-04-06
PL337513A1 (en) 2000-08-28
CA2291251A1 (en) 1998-12-03
NO995796L (no) 1999-11-26
EP0986389A1 (en) 2000-03-22
HUP0003958A3 (en) 2001-06-28
EA199901098A1 (ru) 2000-08-28
TR199902929T2 (xx) 2000-06-21
OA11223A (en) 2003-06-17
JP2002514222A (ja) 2002-05-14
IL133140A0 (en) 2001-03-19
EP0986389B1 (en) 2004-10-13
BR9809687A (pt) 2000-07-11
WO1998053824A1 (en) 1998-12-03
US6489347B1 (en) 2002-12-03
NO995796D0 (no) 1999-11-26
ATE279393T1 (de) 2004-10-15
NZ501285A (en) 2001-10-26
ID24383A (id) 2000-07-13
AU7708998A (en) 1998-12-30
US20040147754A1 (en) 2004-07-29
AP9901698A0 (en) 1999-12-31
CN1268889A (zh) 2000-10-04
BG104034A (en) 2000-11-30
SK159899A3 (en) 2000-06-12

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