HUP0003673A2 - Dioxo-tiazolidinek alkalmazása a hyperglykaemia kezelésére - Google Patents
Dioxo-tiazolidinek alkalmazása a hyperglykaemia kezeléséreInfo
- Publication number
- HUP0003673A2 HUP0003673A2 HU0003673A HUP0003673A HUP0003673A2 HU P0003673 A2 HUP0003673 A2 HU P0003673A2 HU 0003673 A HU0003673 A HU 0003673A HU P0003673 A HUP0003673 A HU P0003673A HU P0003673 A2 HUP0003673 A2 HU P0003673A2
- Authority
- HU
- Hungary
- Prior art keywords
- treatment
- insulin sensitizer
- hyperglycaemia
- thiazolidinediones
- hyperglycemia
- Prior art date
Links
- 201000001421 hyperglycemia Diseases 0.000 title abstract 3
- 229940123464 Thiazolidinedione Drugs 0.000 title 1
- 150000001467 thiazolidinediones Chemical class 0.000 title 1
- 229940122355 Insulin sensitizer Drugs 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya eljárás olyan hyperglykaemia, különösen koplalásoshyperglykaemia kezelésére, amelyben a plazma glükóz koncentrációk 126mg/ml-től 140 mg/dl-ig terjednek, amelynek során egy ilyen kezeléstigénylő emlősnek beadják egy inzulin szenzibilizátor hatásos,nemtoxikus és gyógyászatilag elfogadható mennyiségét. A találmányszerinti eljárásban alkalmazott inzulin szenzibilizátor előnyösen egydioxo-tiazolidin inzulin szenzibilizátor, legelőnyösebben 5-[4-{2-[N-metil-N-(2-piridil)-amino]-etoxi}-benzil]-2,4-dioxo-tiazolidin. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9721692.3A GB9721692D0 (en) | 1997-10-13 | 1997-10-13 | Novel treatment |
| PCT/GB1998/003067 WO1999018944A1 (en) | 1997-10-13 | 1998-10-12 | Use of thiazolidinediones for the treatment of hyperglycaemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003673A2 true HUP0003673A2 (hu) | 2001-10-28 |
| HUP0003673A3 HUP0003673A3 (en) | 2001-12-28 |
Family
ID=10820481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003673A HUP0003673A3 (en) | 1997-10-13 | 1998-10-12 | Use of thiazolidinediones for the treatment of hyperglycaemia |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1023057A1 (hu) |
| JP (1) | JP2001519383A (hu) |
| KR (1) | KR20010024482A (hu) |
| CN (1) | CN1281358A (hu) |
| AP (1) | AP1223A (hu) |
| AU (1) | AU9547198A (hu) |
| BG (1) | BG104405A (hu) |
| BR (1) | BR9815220A (hu) |
| CA (1) | CA2305289A1 (hu) |
| CZ (1) | CZ20001298A3 (hu) |
| EA (1) | EA200000418A1 (hu) |
| GB (1) | GB9721692D0 (hu) |
| HR (1) | HRP20000256A2 (hu) |
| HU (1) | HUP0003673A3 (hu) |
| ID (1) | ID24439A (hu) |
| IL (1) | IL135515A0 (hu) |
| NO (1) | NO20001897L (hu) |
| OA (1) | OA11519A (hu) |
| PL (1) | PL339804A1 (hu) |
| SK (1) | SK5322000A3 (hu) |
| TR (1) | TR200000957T2 (hu) |
| UA (1) | UA66809C2 (hu) |
| WO (1) | WO1999018944A1 (hu) |
| YU (1) | YU28700A (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310620A (zh) * | 1998-07-21 | 2001-08-29 | 史密丝克莱恩比彻姆有限公司 | 利用葡萄糖摄入增强剂减少编程性细胞死亡 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
-
1997
- 1997-10-13 GB GBGB9721692.3A patent/GB9721692D0/en not_active Ceased
-
1998
- 1998-10-12 JP JP2000515579A patent/JP2001519383A/ja active Pending
- 1998-10-12 SK SK532-2000A patent/SK5322000A3/sk unknown
- 1998-10-12 AP APAP/P/2000/001788A patent/AP1223A/en active
- 1998-10-12 IL IL13551598A patent/IL135515A0/xx unknown
- 1998-10-12 EA EA200000418A patent/EA200000418A1/ru unknown
- 1998-10-12 CZ CZ20001298A patent/CZ20001298A3/cs unknown
- 1998-10-12 OA OA1200000107A patent/OA11519A/en unknown
- 1998-10-12 AU AU95471/98A patent/AU9547198A/en not_active Abandoned
- 1998-10-12 CN CN98812016A patent/CN1281358A/zh active Pending
- 1998-10-12 WO PCT/GB1998/003067 patent/WO1999018944A1/en not_active Application Discontinuation
- 1998-10-12 TR TR2000/00957T patent/TR200000957T2/xx unknown
- 1998-10-12 BR BR9815220-3A patent/BR9815220A/pt not_active Application Discontinuation
- 1998-10-12 HU HU0003673A patent/HUP0003673A3/hu unknown
- 1998-10-12 PL PL98339804A patent/PL339804A1/xx unknown
- 1998-10-12 CA CA002305289A patent/CA2305289A1/en not_active Abandoned
- 1998-10-12 KR KR1020007003935A patent/KR20010024482A/ko not_active Application Discontinuation
- 1998-10-12 YU YU28700A patent/YU28700A/sh unknown
- 1998-10-12 EP EP98949088A patent/EP1023057A1/en not_active Withdrawn
- 1998-10-12 UA UA2000042049A patent/UA66809C2/uk unknown
- 1998-10-12 ID IDW20000670A patent/ID24439A/id unknown
-
2000
- 2000-04-12 NO NO20001897A patent/NO20001897L/no not_active Application Discontinuation
- 2000-05-02 HR HR20000256A patent/HRP20000256A2/hr not_active Application Discontinuation
- 2000-05-05 BG BG104405A patent/BG104405A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999018944A1 (en) | 1999-04-22 |
| UA66809C2 (uk) | 2004-06-15 |
| HRP20000256A2 (en) | 2000-12-31 |
| EP1023057A1 (en) | 2000-08-02 |
| OA11519A (en) | 2004-02-09 |
| AP1223A (en) | 2003-11-13 |
| HUP0003673A3 (en) | 2001-12-28 |
| JP2001519383A (ja) | 2001-10-23 |
| NO20001897D0 (no) | 2000-04-12 |
| BG104405A (en) | 2000-12-29 |
| CA2305289A1 (en) | 1999-04-22 |
| AU9547198A (en) | 1999-05-03 |
| KR20010024482A (ko) | 2001-03-26 |
| EA200000418A1 (ru) | 2000-10-30 |
| YU28700A (sh) | 2003-10-31 |
| CN1281358A (zh) | 2001-01-24 |
| BR9815220A (pt) | 2000-11-14 |
| IL135515A0 (en) | 2001-05-20 |
| PL339804A1 (en) | 2001-01-02 |
| CZ20001298A3 (cs) | 2001-08-15 |
| AP2000001788A0 (en) | 2000-06-30 |
| SK5322000A3 (en) | 2000-09-12 |
| TR200000957T2 (tr) | 2000-08-21 |
| GB9721692D0 (en) | 1997-12-10 |
| ID24439A (id) | 2000-07-20 |
| NO20001897L (no) | 2000-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |