HUP0003546A2 - Kompozíciók taxánok orális adagolására embereknek - Google Patents

Kompozíciók taxánok orális adagolására embereknek

Info

Publication number
HUP0003546A2
HUP0003546A2 HU0003546A HUP0003546A HUP0003546A2 HU P0003546 A2 HUP0003546 A2 HU P0003546A2 HU 0003546 A HU0003546 A HU 0003546A HU P0003546 A HUP0003546 A HU P0003546A HU P0003546 A2 HUP0003546 A2 HU P0003546A2
Authority
HU
Hungary
Prior art keywords
taxane
bioavailability
compositions
human patients
orally
Prior art date
Application number
HU0003546A
Other languages
English (en)
Inventor
Samuel Broder
Kenneth L. Duchin
Sami Selim
Original Assignee
Baker Norton Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baker Norton Pharmaceuticals, Inc. filed Critical Baker Norton Pharmaceuticals, Inc.
Publication of HUP0003546A2 publication Critical patent/HUP0003546A2/hu
Publication of HUP0003546A3 publication Critical patent/HUP0003546A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány lehetővé teszi antineoplasztikus taxánok orális adagolásáttaxánra reagáló betegségekben szenvedő pácienseknekbiohozzáférhetőséget fokozó anyagokkal együtt. Taxánként előnyösenpaklitaxelt, biohozzáférhetőséget fokozó anyagként pedig előnyösenciklosporint, célszerűen ciklosporin A-t használnak. A találmányértelmében valamilyen taxánt és egy biohozzáférhetőséget elősegítőanyagot, előnyösen valamilyen ciklosporint együtt alkalmaznak taxánrareagáló betegségek gyógyítására alkalmas, orálisan adagolhatógyógyászati készítmény előállítására. A találmány oltalmi körekiterjed taxánokat és biohozzáférhetőséget fokozó anyagot együtttartalmazó, orálisan adagolható gyógyászati készítményekre is. Ó
HU0003546A 1997-05-27 1998-04-22 Compositions for administering taxanes orally to human patients HUP0003546A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86351397A 1997-05-27 1997-05-27

Publications (2)

Publication Number Publication Date
HUP0003546A2 true HUP0003546A2 (hu) 2002-11-28
HUP0003546A3 HUP0003546A3 (en) 2002-12-28

Family

ID=25341241

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003546A HUP0003546A3 (en) 1997-05-27 1998-04-22 Compositions for administering taxanes orally to human patients

Country Status (23)

Country Link
EP (1) EP0994706B1 (hu)
JP (1) JP2002500667A (hu)
KR (1) KR100615783B1 (hu)
CN (2) CN1550231A (hu)
AR (1) AR012731A1 (hu)
AT (1) ATE308365T1 (hu)
AU (1) AU7130098A (hu)
BR (1) BR9809694A (hu)
CA (1) CA2290446C (hu)
CZ (1) CZ9904244A3 (hu)
DE (1) DE69832173T2 (hu)
DK (1) DK0994706T3 (hu)
ES (1) ES2247690T3 (hu)
HK (1) HK1026637A1 (hu)
HU (1) HUP0003546A3 (hu)
IL (2) IL132992A0 (hu)
NO (1) NO995812L (hu)
PL (1) PL337064A1 (hu)
RU (1) RU2205005C2 (hu)
SK (1) SK157599A3 (hu)
UA (1) UA74767C2 (hu)
WO (1) WO1998053811A1 (hu)
ZA (1) ZA984268B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964946B1 (en) * 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
ATE219363T1 (de) * 1997-06-20 2002-07-15 Baker Norton Pharma Lösliche prodrugs von paclitaxel
GB9718903D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
EP1749540B1 (en) 1999-05-17 2010-10-13 Cancer Research Ventures Limited Compositions for improving bioavailability of orally administered drugs
IL149360A0 (en) * 1999-10-27 2002-11-10 Baker Norton Pharma Method and compositions for administering taxanes orally to human patients
KR20020013174A (ko) * 2000-08-11 2002-02-20 민경윤 경구 흡수율이 낮은 약물의 흡수율을 증가시키기 위한경구용 조성물
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
NZ539046A (en) * 2001-01-18 2006-11-30 Pharmacia & Upjohn Co Llc Chemotherapeutic self-emulsifying microemulsion compositions of paclitaxel with improved oral bioavailability
UY27185A1 (es) * 2001-02-28 2002-09-30 Bristol Myers Squibb Co Dosificación metronómica de taxanos
SI1372636T1 (sl) * 2001-02-28 2006-12-31 Bristol Myers Squibb Co Metronomsko odmerjanje taksanov za inhibiranje tumorske rasti
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
GB0523659D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
CN102803234A (zh) * 2009-06-02 2012-11-28 霓坎制药有限责任公司 用于治疗疾病的人甲酰基肽受体的拮抗作用
EP4059497A1 (en) * 2021-03-17 2022-09-21 Dompé farmaceutici S.p.a. C5ar1 inhibitors for treating hypersensitivity reactions to taxanes
BR112023018826A2 (pt) * 2021-03-17 2024-03-12 Dompe Farm Spa Inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
EP0563134B1 (en) * 1990-12-18 1996-06-19 The Wellcome Foundation Limited Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
CZ283038B6 (cs) * 1991-01-11 1997-12-17 Laboratoires Glaxo Sa Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem
US5567592A (en) * 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
DK0773938T3 (da) * 1994-07-26 1999-09-20 Indena Spa Semi-syntetiske taxaner med anti-tumoraktivitet
TW354293B (en) * 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
CA2224227A1 (en) * 1995-06-07 1996-12-19 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
EP0822815A4 (en) * 1996-01-31 1998-04-01 Bristol Myers Squibb Co PROCESS FOR MAKING ORAL-LIKE TAXANES ACTIVE FROM THE PHARMACEUTICAL VIEW
US6025359A (en) * 1996-06-17 2000-02-15 Eli Lilly And Company Drug resistance and multidrug resistance modulators
GB9718903D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CA2326485C (en) * 1998-04-01 2008-12-09 Rtp Pharma Inc. Anticancer compositions

Also Published As

Publication number Publication date
IL132992A0 (en) 2001-03-19
CA2290446A1 (en) 1998-12-03
HK1026637A1 (en) 2000-12-22
CN1550231A (zh) 2004-12-01
DE69832173T2 (de) 2006-08-03
NO995812D0 (no) 1999-11-26
CN1261275A (zh) 2000-07-26
AR012731A1 (es) 2000-11-08
CA2290446C (en) 2008-01-29
UA74767C2 (en) 2006-02-15
CZ9904244A3 (cs) 2001-10-17
DE69832173D1 (de) 2005-12-08
WO1998053811A1 (en) 1998-12-03
RU2205005C2 (ru) 2003-05-27
HUP0003546A3 (en) 2002-12-28
IL132992A (en) 2006-08-20
NO995812L (no) 2000-01-25
ZA984268B (en) 1999-06-23
KR20010013025A (ko) 2001-02-26
ATE308365T1 (de) 2005-11-15
BR9809694A (pt) 2000-10-03
EP0994706A1 (en) 2000-04-26
AU7130098A (en) 1998-12-30
SK157599A3 (en) 2002-10-08
PL337064A1 (en) 2000-07-31
ES2247690T3 (es) 2006-03-01
KR100615783B1 (ko) 2006-08-25
JP2002500667A (ja) 2002-01-08
DK0994706T3 (da) 2006-03-06
EP0994706B1 (en) 2005-11-02
EP0994706A4 (en) 2001-05-16

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Legal Events

Date Code Title Description
FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): DR. PALAGYI TIVADAR, DANUBIA SZABADALMI ES VEDJEGY IRODA KFT., HU

Representative=s name: SZENTPETERI ZSOLT, S.B.G. & K. SZABADALMI UEGY, HU

FH92 Termination of representative

Representative=s name: DR. PALAGYI TIVADAR, DANUBIA SZABADALMI ES VED, HU

HC9A Change of name, address

Owner name: IVAX RESEARCH, INC., US

Free format text: FORMER OWNER(S): BAKER NORTON PHARMACEUTICALS, INC., US

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished