HUP0003219A2 - Ftalazinszármazékok, eljárás előállításukra és e vegyületeket tartalmazó gyógyászati készítmények, valamint a vegyületek alkalmazása erekciós diszfunkció kezelésére alkalmas gyógyászati készítmények előállítására - Google Patents

Ftalazinszármazékok, eljárás előállításukra és e vegyületeket tartalmazó gyógyászati készítmények, valamint a vegyületek alkalmazása erekciós diszfunkció kezelésére alkalmas gyógyászati készítmények előállítására

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Publication number
HUP0003219A2
HUP0003219A2 HU0003219A HUP0003219A HUP0003219A2 HU P0003219 A2 HUP0003219 A2 HU P0003219A2 HU 0003219 A HU0003219 A HU 0003219A HU P0003219 A HUP0003219 A HU P0003219A HU P0003219 A2 HUP0003219 A2 HU P0003219A2
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HU
Hungary
Prior art keywords
group
substituents
optionally
alkyl
pharmaceutical compositions
Prior art date
Application number
HU0003219A
Other languages
English (en)
Inventor
Hideyuki Adachi
Hiroki Ishihara
Atsushi Kamada
Toshihiko Kaneko
Norio Karibe
Kohtarou Kodama
Kazuki Miyazaki
Shuhei Miyazawa
Tadashi Nagakura
Yoshimitsu Naoe
Fumihiro Ozaki
Itaru Tsukada
Nobuhisa Watanabe
Original Assignee
Eisai Co., Ltd.
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Publication date
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Publication of HUP0003219A2 publication Critical patent/HUP0003219A2/hu
Publication of HUP0003219A3 publication Critical patent/HUP0003219A3/hu

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    • C07—ORGANIC CHEMISTRY
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgyát az (I) általános képletűftalazinvegyületek valamint ezeket tartalmazó gyógyászati készítményekképezik. A találmány szerinti (I) általános képletű vegyületekalkalmazhatók erekciós diszfunkció kezelésére vagy megelőzésére,valamint nőknél szexuális diszfunkció vagy diszmenorrhea kezelésérevagy megelőzésére. Az (I) általános képletben a szubsztituensekjelentése igen sokféle, így például R1és R2 jelentése azonos vagyegymástól eltérő halogénatom, adott esetben halogénatommalszubsztituált 1-4 szénatomos alkilcsoport, hidroxilcsoport, adottesetben halogénatommal szubsztituált 1-4 szénatomos alkoxicsoport vagycianocsoport; X jelentése ciano-, nitrocsoport, halogénatom,tiokarbamoil-, hidroxiimino-csoport, aril-(1-4 szénatomos alkil)- vagykarboxi(1-4 szénatomos alkil)-csoport vagy heteroarilcsoport, amely 1-3 szubsztituenst hordozhat az alábbiakban az A csoportban megadottakközül; Y jelentése (i) (II)-(VI) általános képlétű csoport, ahol aszubsztituensek jelentése igen sokféle, (ii) alkinilcsoport vagyalkenilcsoport vagy egy alkilcsoport, amely csoportok mindegyikeszubsztituenst hordozhat; (iii) fenilcsoport, amely 1-3 szubsztituensthordozhat az A csoportban felsorolt szubsztituensek közül választva,vagy (iv) piridil-, pirimidil-, tienil-, tiazolil- vagy furilcsoport,amely csoportok mindegyike 1-3 szubsztituenst hordozhat az alábbi Acsoportban definiált csoportok közül választva: A) szubsztituenscsoport jelentése lehet például 1-4 szénatomos alkilcsoport; 1-4szénatomos alkoxicsoport, amelyek halogénatommal, ciano-, nitro- vagyhidroxilcsoporttal lehetnek szubsztituálva; cianocsoport,nitrocsoport, adott esetben védőcsoportot hordozó karboxilcsoport;adott esetben védőcsoportot hordozó hidroxilcsoport; I értéke 1, 2vagy 3. Ó
HU0003219A 1998-02-19 1999-02-17 Phthalazine derivatives, process for producing them and pharmaceutical compositions containing them and use of the compounds for producing pharmaceutical compositions useful for treating erectile dysfunction HUP0003219A3 (en)

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PCT/JP1999/000688 WO1999042452A1 (fr) 1998-02-19 1999-02-17 Derives de phtalazine et remedes contre la dyserection

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE343388T1 (de) 2000-04-19 2006-11-15 Lilly Icos Llc Pde-v hemmer zur behandlung von morbus parkinson
US6803906B1 (en) * 2000-07-05 2004-10-12 Smart Technologies, Inc. Passive touch system and method of detecting user input
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
EP1442042A1 (en) 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
EP1710235A4 (en) * 2004-01-30 2008-12-17 Beijing Tuolin Medicine Scienc EXTRACTS OF MARASMINS ANDROSACEUS L.ES, PIPERDINONE DERIVATIVES AND THEIR USE AS BLOOD PRESSURE MEDICINES
AU2005277384B2 (en) 2004-08-17 2011-11-17 The Johns Hopkins University PDE5 inhibitor compositions and methods for treating cardiac indications
WO2006074223A2 (en) * 2005-01-03 2006-07-13 Myriad Genetics, Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
US7759337B2 (en) 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
US8772481B2 (en) 2008-10-10 2014-07-08 Amgen Inc. Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof
WO2010042649A2 (en) 2008-10-10 2010-04-15 Amgen Inc. PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF
FR2941696B1 (fr) 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
CN102060749B (zh) * 2009-11-12 2013-07-10 上海药明康德新药开发有限公司 2-氰基-7-氮杂-螺[3,5]壬烷衍生物的制备方法
WO2014100733A1 (en) 2012-12-21 2014-06-26 Mayo Foundation For Medical Education And Research Methods and materials for treating calcific aortic valve stenosis
CN109912586A (zh) * 2013-09-06 2019-06-21 日本曹达株式会社 内型-9-氮杂双环［3.3.1］壬烷-3-醇衍生物的制造方法
CN108395377A (zh) * 2018-01-16 2018-08-14 吴江信凯医药科技有限公司 一种3-氯-4-甲氧基苄胺盐酸盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754091A (en) * 1985-02-28 1988-06-28 Amoco Corporation Conversion of a lower alkane
MY104343A (en) 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
TW279162B (hu) * 1991-09-26 1996-06-21 Mitsubishi Chem Corp
JP3919835B2 (ja) 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
ES2224130T3 (es) * 1994-08-09 2005-03-01 Eisai Co., Ltd. Compuesto de piridazina condensada.
JPH09135938A (ja) 1995-11-16 1997-05-27 Toyota Motor Corp 水陸両用ボ−ト
WO1998007430A1 (fr) * 1996-08-20 1998-02-26 Eisai Co., Ltd. Medicament contre les defaillances de l'erection, renfermant un compose a base de pyridazine fondue

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NZ503399A (en) 2003-01-31
CN1210265C (zh) 2005-07-13

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