HUP0002681A3 - Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same - Google Patents
Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the sameInfo
- Publication number
- HUP0002681A3 HUP0002681A3 HU0002681A HUP0002681A HUP0002681A3 HU P0002681 A3 HUP0002681 A3 HU P0002681A3 HU 0002681 A HU0002681 A HU 0002681A HU P0002681 A HUP0002681 A HU P0002681A HU P0002681 A3 HUP0002681 A3 HU P0002681A3
- Authority
- HU
- Hungary
- Prior art keywords
- carboxylic acid
- pharmaceutical compositions
- same
- compositions containing
- acid derivatives
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical class OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87718797A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011821 WO1998057933A1 (en) | 1997-06-17 | 1998-06-08 | Pyrrolidine carboxylic acid derivatives as endothelin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002681A2 HUP0002681A2 (hu) | 2001-08-28 |
| HUP0002681A3 true HUP0002681A3 (en) | 2001-09-28 |
Family
ID=25369437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002681A HUP0002681A3 (en) | 1997-06-17 | 1998-06-08 | Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR016071A1 (hu) |
| AU (1) | AU7826398A (hu) |
| BG (1) | BG103986A (hu) |
| HU (1) | HUP0002681A3 (hu) |
| NO (1) | NO996244L (hu) |
| PL (1) | PL348667A1 (hu) |
| WO (1) | WO1998057933A1 (hu) |
| ZA (1) | ZA985209B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| WO2001027135A2 (en) | 1999-10-13 | 2001-04-19 | Johns Hopkins University School Of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| WO2001026644A2 (en) * | 1999-10-14 | 2001-04-19 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| AR044510A1 (es) * | 2003-04-14 | 2005-09-14 | Merck & Co Inc | Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina |
| CN114507143A (zh) * | 2022-02-26 | 2022-05-17 | 江苏壹药新材料有限公司 | 一种2-乙基-1-氟-4-硝基苯的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69527072T2 (de) * | 1994-08-19 | 2003-02-13 | Abbott Lab | Endothelin antagoniste |
| DE69714024T2 (de) * | 1996-02-13 | 2003-03-20 | Abbott Lab | 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carbonsaure-derivate als endothelin-antagonisten |
-
1998
- 1998-06-08 AU AU78263/98A patent/AU7826398A/en not_active Abandoned
- 1998-06-08 WO PCT/US1998/011821 patent/WO1998057933A1/en not_active Application Discontinuation
- 1998-06-08 HU HU0002681A patent/HUP0002681A3/hu unknown
- 1998-06-08 PL PL98348667A patent/PL348667A1/xx unknown
- 1998-06-15 ZA ZA985209A patent/ZA985209B/xx unknown
- 1998-06-16 AR ARP980102851A patent/AR016071A1/es unknown
-
1999
- 1999-12-10 BG BG103986A patent/BG103986A/xx unknown
- 1999-12-16 NO NO996244A patent/NO996244L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002681A2 (hu) | 2001-08-28 |
| BG103986A (en) | 2000-08-31 |
| PL348667A1 (en) | 2002-06-03 |
| ZA985209B (en) | 1999-01-06 |
| NO996244L (no) | 2000-01-12 |
| WO1998057933A1 (en) | 1998-12-23 |
| AR016071A1 (es) | 2001-06-20 |
| AU7826398A (en) | 1999-01-04 |
| NO996244D0 (no) | 1999-12-16 |
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