HUP0002266A2 - Eljárás steril acyclovir kenőcs előállítására - Google Patents

Eljárás steril acyclovir kenőcs előállítására

Info

Publication number
HUP0002266A2
HUP0002266A2 HU0002266A HUP0002266A HUP0002266A2 HU P0002266 A2 HUP0002266 A2 HU P0002266A2 HU 0002266 A HU0002266 A HU 0002266A HU P0002266 A HUP0002266 A HU P0002266A HU P0002266 A2 HUP0002266 A2 HU P0002266A2
Authority
HU
Hungary
Prior art keywords
sterile
acyclovir
ointment
mixture
acid addition
Prior art date
Application number
HU0002266A
Other languages
English (en)
Inventor
Kálmánné Nagy
Katalin Baranek
János Egri
Antal Mosonyi
Jenőné Szeli
Györgyné Clementis
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0002266A priority Critical patent/HU226058B1/hu
Publication of HU0002266D0 publication Critical patent/HU0002266D0/hu
Priority to AU2001269346A priority patent/AU2001269346A1/en
Priority to CZ20023731A priority patent/CZ20023731A3/cs
Priority to PCT/HU2001/000069 priority patent/WO2001095878A1/en
Priority to SK1677-2002A priority patent/SK16772002A3/sk
Priority to DE60106024T priority patent/DE60106024D1/de
Priority to UA20021210046A priority patent/UA73769C2/uk
Priority to JP2002510057A priority patent/JP2004503485A/ja
Priority to EP01947701A priority patent/EP1289495B1/en
Priority to PL01358136A priority patent/PL358136A1/xx
Priority to AT01947701T priority patent/ATE277597T1/de
Priority to EA200201188A priority patent/EA200201188A1/ru
Priority to YU86302A priority patent/YU86302A/sh
Publication of HUP0002266A2 publication Critical patent/HUP0002266A2/hu
Priority to HRP20020857 priority patent/HRP20020857A2/hr
Priority to BG107386A priority patent/BG107386A/bg
Publication of HUP0002266A3 publication Critical patent/HUP0002266A3/hu
Publication of HU226058B1 publication Critical patent/HU226058B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya eljárás hatóanyagként acyclovirt tartalmazó sterilkenőcs, különösen szemkenőcs előállítására mikronizált acyclovir vagygyógyászatilag alkalmas savaddíciós sója és a kenőcs sterilvivőanyagainak aszeptikus módon történő összekeverése, végül a homogénkenőcs steril edénybe töltése, és az edény lezárása útján. A találmányértelmében úgy járnak el, hogy 1 tömegrész 60mm-nél kisebbrészecskeméretű acyclovirt vagy gyógyászatilag alkalmas savaddícióssóját 1-30 tömegrész vazelinnel és/vagy folyékony paraffinnal és/vagyszilárd és folyékony paraffin keverékével összekevernek, a keveréketlégmentesen lezárt térben 120-150 °C-on tartják 0,3-5 órán át, majd asteril keveréket a vivőanyagok további, steril részévelhomogenizálják. Ó
HU0002266A 2000-06-14 2000-06-14 Process for producing sterile acyclovir cream HU226058B1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
HU0002266A HU226058B1 (en) 2000-06-14 2000-06-14 Process for producing sterile acyclovir cream
YU86302A YU86302A (sh) 2000-06-14 2001-06-13 Postupak za pripremanje sterilne masti koja sadrži aciklovir
EP01947701A EP1289495B1 (en) 2000-06-14 2001-06-13 Process for the preparation of a sterile ointment containing acyclovir
AT01947701T ATE277597T1 (de) 2000-06-14 2001-06-13 Verfahren zur herstellung von sterilsalbe enthaltend acyclovir
PCT/HU2001/000069 WO2001095878A1 (en) 2000-06-14 2001-06-13 Process for the preparation of a sterile ointment containing acyclovir
SK1677-2002A SK16772002A3 (sk) 2000-06-14 2001-06-13 Spôsob prípravy sterilnej masti obsahujúcej acyklovírus
DE60106024T DE60106024D1 (de) 2000-06-14 2001-06-13 Verfahren zur herstellung von sterilsalbe enthaltend acyclovir
UA20021210046A UA73769C2 (hu) 2000-06-14 2001-06-13
JP2002510057A JP2004503485A (ja) 2000-06-14 2001-06-13 アシクロビルを含有する無菌軟膏の製法
AU2001269346A AU2001269346A1 (en) 2000-06-14 2001-06-13 Process for the preparation of a sterile ointment containing acyclovir
PL01358136A PL358136A1 (en) 2000-06-14 2001-06-13 Process for the preparation of a sterile ointment containing acyclovir
CZ20023731A CZ20023731A3 (cs) 2000-06-14 2001-06-13 Způsob přípravy sterilní masti obsahující acyklovir
EA200201188A EA200201188A1 (ru) 2000-06-14 2001-06-13 Способ получения стерильной мази, содержащей ацикловир
HRP20020857 HRP20020857A2 (en) 2000-06-14 2002-10-28 Process for the preparation of a sterile ointment containing acyclovir
BG107386A BG107386A (bg) 2000-06-14 2002-12-13 Метод за получаване на стерилен мехлем съдържащ ацикловир

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0002266A HU226058B1 (en) 2000-06-14 2000-06-14 Process for producing sterile acyclovir cream

Publications (4)

Publication Number Publication Date
HU0002266D0 HU0002266D0 (en) 2000-08-28
HUP0002266A2 true HUP0002266A2 (hu) 2002-05-29
HUP0002266A3 HUP0002266A3 (en) 2005-01-28
HU226058B1 HU226058B1 (en) 2008-04-28

Family

ID=89978395

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002266A HU226058B1 (en) 2000-06-14 2000-06-14 Process for producing sterile acyclovir cream

Country Status (15)

Country Link
EP (1) EP1289495B1 (hu)
JP (1) JP2004503485A (hu)
AT (1) ATE277597T1 (hu)
AU (1) AU2001269346A1 (hu)
BG (1) BG107386A (hu)
CZ (1) CZ20023731A3 (hu)
DE (1) DE60106024D1 (hu)
EA (1) EA200201188A1 (hu)
HR (1) HRP20020857A2 (hu)
HU (1) HU226058B1 (hu)
PL (1) PL358136A1 (hu)
SK (1) SK16772002A3 (hu)
UA (1) UA73769C2 (hu)
WO (1) WO2001095878A1 (hu)
YU (1) YU86302A (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2492989C (en) * 2002-07-23 2012-11-20 Novartis Ag Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
CN115463102B (zh) * 2022-09-26 2023-11-24 湖北科益药业股份有限公司 一种阿昔洛韦片剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300296A (en) * 1989-11-06 1994-04-05 Frank J. Holly Antimicrobial agent for opthalmic formulations
CZ284920B6 (cs) * 1996-02-14 1999-04-14 Vladimír Prof. Mudr. Drsc. Vonka Preparáty pro léčbu rekurentního herpesu založené na potenciaci účinků syntetických virostatik kofeinem
ITMI981528A1 (it) * 1998-07-03 2000-01-03 Recordati Ind Chimica E Farma Formulazioni topiche di aciclovir

Also Published As

Publication number Publication date
WO2001095878A1 (en) 2001-12-20
HU0002266D0 (en) 2000-08-28
ATE277597T1 (de) 2004-10-15
HUP0002266A3 (en) 2005-01-28
EP1289495B1 (en) 2004-09-29
SK16772002A3 (sk) 2003-04-01
AU2001269346A1 (en) 2001-12-24
EA200201188A1 (ru) 2003-06-26
CZ20023731A3 (cs) 2003-04-16
DE60106024D1 (de) 2004-11-04
PL358136A1 (en) 2004-08-09
JP2004503485A (ja) 2004-02-05
UA73769C2 (hu) 2005-09-15
EP1289495A1 (en) 2003-03-12
YU86302A (sh) 2005-11-28
BG107386A (bg) 2003-11-28
HRP20020857A2 (en) 2004-12-31
HU226058B1 (en) 2008-04-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU