HUP0001061A2 - Naftilszulfonsavszármazékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Naftilszulfonsavszármazékok és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0001061A2
HUP0001061A2 HU0001061A HUP0001061A HUP0001061A2 HU P0001061 A2 HUP0001061 A2 HU P0001061A2 HU 0001061 A HU0001061 A HU 0001061A HU P0001061 A HUP0001061 A HU P0001061A HU P0001061 A2 HUP0001061 A2 HU P0001061A2
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HU
Hungary
Prior art keywords
cycloalkyl
alkyl
alkyloxy
alkylthio
cyano
Prior art date
Application number
HU0001061A
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English (en)
Inventor
David Mark Rotstein
Eric Brian Sjogren
Original Assignee
F.Hoffmann-La Roche Ag.
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Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP0001061A2 publication Critical patent/HUP0001061A2/hu
Publication of HUP0001061A3 publication Critical patent/HUP0001061A3/hu

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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C317/00—Sulfones; Sulfoxides
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    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
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Abstract

A találmány tárgyát (I) általánős képletű új vegyületek (melyképletben A jelentése kémiai kötés, -CH2- , -CH(OH)- , -C=NOR4-, -C(O)-, -NR5- , -O- vagy -S(O)n-, Z jelentése (B) , (C) , (D) vagy (E)általánős képletű csőpőrt; nl értéke 0-3 X jelentése -O- vagy -S- R6és R7 jelentése egymástól függetlenül hidrőgénatőm, alkil-, halőgén-alkil-, ciklőalkil-, ciklőalkil-alkil-, acil-, alki-tiő-, ciklőalkil-tiő-, ciklőalkil-alkil-tiő-, alkőxi-, ciklőalkőxi- ciklőalkil-alkőxi-,halőgén-alkőxi-, alkenilcsőpőrt, halőgénatőm, cianő-, nitrő-,hidrőxil- vagy -NR9Rl0 csőpőrt, R6 és R7 együtt metilén-diőxi- vagyetilén-diőxi-csőpőrtőt képez; R8 jelentése hidrőgénatőm, alkil-,halőgén-alkil-, alkőxi-, ciklőalkőxi-, halőgén-alkőxi-, alkil-tiő-,ciklőalkil-tiő-nitrő-, cianő-, hidrőxilcsőpőrt vagy halőgénatőm; Rljelentése hidrőgénatőm, alkil-, alkenil-, alkinil-, halőgén-alkil-,ciklőalkil-, ciklőalkil-alkil-, alkőxi-, alkenilőxi-, ciklőalkőxi-,ciklőalkil-alkőxi-, halőgén-alkőxi-hidrőxi-alkőxi-, alkőxi-alkőxi-,alkil-tiő-, ciklőalkil-tiő-, ciklőalkil-alkil-tiő-, hidrőxilcsőpőrt,halőgénatőm, cianő-, karbőxil-, alkőxi-karbőnil-, acil-, -C=NOR4,NR9R10, -CONR9R10, -OCONR9R10 vagy -OSO2R11 csőpőrt; R2 jelentésehidrőgénatőm, alkil-, alkőxicsőpőrt, halőgénatőm, nitrő- vagy -NR9R10csőpőrt, R3 jelentése -SO2R12 vagy -SO2NR13R14) és gyógyászatilagalkalmas sóik, az ezeket tartalmazó gyógyszerkészítmények képezik,amelyek gyűlladásős és aűtőimműn betegségek kezelésére alkalmazhatók. ŕ
HU0001061A 1997-01-28 1998-01-21 Naphthylsulfonic acid derivatives and pharmaceutical compositions containing them HUP0001061A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3646697P 1997-01-28 1997-01-28
PCT/EP1998/000306 WO1998032732A1 (en) 1997-01-28 1998-01-21 5-aroylnaphthalene derivatives

Publications (2)

Publication Number Publication Date
HUP0001061A2 true HUP0001061A2 (hu) 2000-09-28
HUP0001061A3 HUP0001061A3 (en) 2001-02-28

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HU0001061A HUP0001061A3 (en) 1997-01-28 1998-01-21 Naphthylsulfonic acid derivatives and pharmaceutical compositions containing them

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US (2) US5962531A (hu)
EP (1) EP0966437B1 (hu)
JP (1) JP3607706B2 (hu)
KR (1) KR100313180B1 (hu)
CN (1) CN1159293C (hu)
AR (1) AR011571A1 (hu)
AT (1) ATE219051T1 (hu)
AU (1) AU721407B2 (hu)
BR (1) BR9807520A (hu)
CA (1) CA2278687C (hu)
CO (1) CO4930273A1 (hu)
CZ (1) CZ259399A3 (hu)
DE (2) DE69805974T2 (hu)
DK (1) DK0966437T3 (hu)
ES (2) ES2178162T3 (hu)
FR (1) FR2758818B1 (hu)
GB (1) GB2321457B (hu)
HR (1) HRP980046A2 (hu)
HU (1) HUP0001061A3 (hu)
ID (1) ID22825A (hu)
IL (1) IL130909A0 (hu)
IT (1) IT1298159B1 (hu)
MA (1) MA26469A1 (hu)
NO (1) NO313136B1 (hu)
NZ (1) NZ336684A (hu)
PA (1) PA8444901A1 (hu)
PE (1) PE51499A1 (hu)
PL (1) PL334769A1 (hu)
PT (1) PT966437E (hu)
RU (1) RU2188192C2 (hu)
SV (1) SV1998000013A (hu)
TN (1) TNSN98013A1 (hu)
TR (1) TR199901783T2 (hu)
TW (1) TW520355B (hu)
UY (1) UY24860A1 (hu)
WO (1) WO1998032732A1 (hu)
YU (1) YU34499A (hu)
ZA (1) ZA98495B (hu)

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AU2001277560A1 (en) 2000-08-09 2002-02-18 F. Hoffmann-La Roche Ag Quinolene derivatives as anti-inflammation agents
MXPA04008104A (es) * 2002-02-22 2006-05-25 Upjohn Co Derivados de arilsulfona.
CN1675154A (zh) * 2002-06-07 2005-09-28 科蒂科股份有限公司 抑制巨噬细胞移动抑制因子(mif)的细胞因子或生物活性的萘衍生物
EP1692101B1 (en) * 2003-03-31 2011-07-06 Council of Scientific and Industrial Research Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof
DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
JP2009541219A (ja) * 2006-06-12 2009-11-26 メルク エンド カムパニー インコーポレーテッド 高眼圧治療のための眼科組成物
WO2013086229A1 (en) * 2011-12-07 2013-06-13 Amgen Inc. Bicyclic aryl and heteroaryl sodium channel inhibitors
WO2014201173A1 (en) 2013-06-12 2014-12-18 Amgen Inc. Bicyclic sulfonamide compounds as sodium channel inhibitors

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NO993633D0 (no) 1999-07-27
DE69805974T2 (de) 2003-02-20
CO4930273A1 (es) 2000-06-27
KR100313180B1 (ko) 2001-11-14
WO1998032732A1 (en) 1998-07-30
HUP0001061A3 (en) 2001-02-28
GB2321457B (en) 2001-02-28
FR2758818A1 (fr) 1998-07-31
ITMI980090A1 (it) 1999-07-20
CA2278687C (en) 2004-03-30
DK0966437T3 (da) 2002-10-07
EP0966437A1 (en) 1999-12-29
TW520355B (en) 2003-02-11
DE19803003A1 (de) 1998-07-30
AU6095698A (en) 1998-08-18
PA8444901A1 (es) 2000-05-24
US5962531A (en) 1999-10-05
CA2278687A1 (en) 1998-07-30
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JP3607706B2 (ja) 2005-01-05
IL130909A0 (en) 2001-01-28
YU34499A (sh) 2002-03-18
CN1246109A (zh) 2000-03-01
SV1998000013A (es) 1998-09-18
GB2321457A (en) 1998-07-29
HRP980046A2 (en) 1998-10-31
UY24860A1 (es) 2000-12-29
NZ336684A (en) 2001-04-27
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IT1298159B1 (it) 1999-12-20
US6150397A (en) 2000-11-21
AU721407B2 (en) 2000-07-06
ES2135351B1 (es) 2000-05-16
BR9807520A (pt) 2000-03-21
ES2135351A1 (es) 1999-10-16
FR2758818B1 (fr) 1999-09-03
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DE69805974D1 (de) 2002-07-18
NO313136B1 (no) 2002-08-19
EP0966437B1 (en) 2002-06-12
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ATE219051T1 (de) 2002-06-15
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CN1159293C (zh) 2004-07-28
NO993633L (no) 1999-09-27
ZA98495B (en) 1998-07-08
CZ259399A3 (cs) 1999-11-17
KR20000070487A (ko) 2000-11-25
MA26469A1 (fr) 2004-12-20
PE51499A1 (es) 1999-05-26
ES2178162T3 (es) 2002-12-16
RU2188192C2 (ru) 2002-08-27

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