YU34499A - Derivati 5-aroilnaftalena - Google Patents

Derivati 5-aroilnaftalena

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Publication number
YU34499A
YU34499A YU34499A YU34499A YU34499A YU 34499 A YU34499 A YU 34499A YU 34499 A YU34499 A YU 34499A YU 34499 A YU34499 A YU 34499A YU 34499 A YU34499 A YU 34499A
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YU
Yugoslavia
Prior art keywords
alkyl
hydrogen
acyl
halogenalkyl
alkoxy
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YU34499A
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English (en)
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David Mark Rotstein
Eric Brian Sjorgen
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F. Hoffmann-La Roche Ag.
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Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU34499A publication Critical patent/YU34499A/sh

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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Abstract

Ovaj pronalazak se odnosi na odredene derivate 5-aroilnaftalena formule (I), u kojoj A je veza, -CH2-, -CH(OH)-, -C=NOR4-, -C(O)-, -O-, ili -S(O)n-, gde je n ceo broj od 0 do 2, R4 je vodonik ili alkil, R5 je vodonik, alkil, ili acil, Z je grupa predstavljena formulama (B), (C), (D) ili (E), gde n1 jo 0 do 3; X je O ili S; R6 i R7 se nezavisno biraju od vodonik, alkil, halogenalkil, cikloalkil, cikloalkilalkil, acil, alkiltio, cikloalkiltio, cikloalkilalkiltio, alkoksi, cikloalkoksi, cikloalkilalkoksi, halogenalkiloksi, alkenil, halogen, cijano, nitro, hidroksi, ili -NR9R10 gde su R9 i R10 nezavisno vodonik, alkil, ili acil ili R6 i R7 kada su medusobno susedni stvaraju metilendioksi ili etilendioksi; R8 je vodonik, alkil, halogenalkil, alkoksi, cikloalkoksi, halogenalkiloksi, alkiltio, cikloalkiltio, nitro, cijano, hidroksi ili halogen; R1 je vodonik, alkil, alkenil, alkinil, halogenalkil, ciklolalkil, cikloalkilalkil, alkoksi, alkeniloksi, cikloalkiloksi, cikloalkilalkiloksi, halogenalkiloksi, hidroksialkiloksi, alkoksialkiloksi, alkiltio, cikloalkiltio, cikloalkilalkiltio, hidroksi, halogen, cijano, karboksi, alkoksikarbonil, acil, -C=NOR4, -NR9R10, -CONR9R10 ili -OSO2R11, gde su R4R9 i R10 kako je ranije definisano, a R11 je alkil, cikloalkil ili halogenalkil; R2 je vodonik, alkil, alkoksi, halogen, nitro ili -NR9R10; a R3 je -SO2R12 ili -SO2NR13R14, gde R12 je alkil, hidrokslalkil, alkoksialkil, karboksialkil ili alkoksikarbonilalkil; R13 i je vodonik, alkil, ili acil; a R14 je vodonik, alkil, halogenalkil, cikloalkil, cikloalkilalkil, alkenil, hidroksialkil, alkoksialkil, alkoksikarbonilalkil, amino, aminoalkil, aril, aralkil, heteroalkil, heterociklo, heterocikloalkil, acil, hidroksi ili alkoksi; ili R13 i R14 zajedno sa atomom azota za koji su vezani po zelji formiraju jednu heterocikloamino grupu; koji su inhibitori prostaglandin G/H sintaze, farmaceutski preparati sa njihovim sadrzajem, postupci za njihovu upotrebu i postupci za njihovo pripremanje.
YU34499A 1997-01-28 1998-01-21 Derivati 5-aroilnaftalena YU34499A (sh)

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UY (1) UY24860A1 (sh)
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DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
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NO993633D0 (no) 1999-07-27
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KR100313180B1 (ko) 2001-11-14
WO1998032732A1 (en) 1998-07-30
HUP0001061A3 (en) 2001-02-28
GB2321457B (en) 2001-02-28
FR2758818A1 (fr) 1998-07-31
ITMI980090A1 (it) 1999-07-20
CA2278687C (en) 2004-03-30
DK0966437T3 (da) 2002-10-07
EP0966437A1 (en) 1999-12-29
TW520355B (en) 2003-02-11
DE19803003A1 (de) 1998-07-30
AU6095698A (en) 1998-08-18
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US5962531A (en) 1999-10-05
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JP3607706B2 (ja) 2005-01-05
IL130909A0 (en) 2001-01-28
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HUP0001061A2 (hu) 2000-09-28
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MA26469A1 (fr) 2004-12-20
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