HUP0000442A2 - Lentivirális vektorok - Google Patents

Lentivirális vektorok

Info

Publication number
HUP0000442A2
HUP0000442A2 HU0000442A HUP0000442A HUP0000442A2 HU P0000442 A2 HUP0000442 A2 HU P0000442A2 HU 0000442 A HU0000442 A HU 0000442A HU P0000442 A HUP0000442 A HU P0000442A HU P0000442 A2 HUP0000442 A2 HU P0000442A2
Authority
HU
Hungary
Prior art keywords
lentiviral
lentiviral vectors
rna
miniviral
provirus
Prior art date
Application number
HU0000442A
Other languages
English (en)
Inventor
Alan John Kingsman
Susan Mary Kingsman
Original Assignee
Oxford Biomedica (Uk) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biomedica (Uk) Limited filed Critical Oxford Biomedica (Uk) Limited
Publication of HUP0000442A2 publication Critical patent/HUP0000442A2/hu
Publication of HUP0000442A3 publication Critical patent/HUP0000442A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mushroom Cultivation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát nemősztódó emlős célsejtek megfertőzésére, éstranszdűkálására képes retrővirális vektőrrészecskék képezik, amelyeklentivírűsőkőn, azaz példáűl HIV-vírűsőn alapűlnak, és őlyan RNS-genőmmal rendelkeznek, amit úgy készítettek el, hőgy az RNS-prővírűsban egy nemlentivirális szabályőzó elemet biztősítsőn aprővírűs 5' LTR-jében. ŕ
HU0000442A 1996-10-17 1997-10-17 Lentiviral vectors HUP0000442A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9621680.9A GB9621680D0 (en) 1996-10-17 1996-10-17 Lentiviral vectors
PCT/GB1997/002858 WO1998017816A1 (en) 1996-10-17 1997-10-17 Lentiviral vectors

Publications (2)

Publication Number Publication Date
HUP0000442A2 true HUP0000442A2 (hu) 2000-06-28
HUP0000442A3 HUP0000442A3 (en) 2001-09-28

Family

ID=10801598

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000442A HUP0000442A3 (en) 1996-10-17 1997-10-17 Lentiviral vectors

Country Status (18)

Country Link
US (1) US6235522B1 (hu)
EP (1) EP0939827B1 (hu)
JP (1) JP2001502903A (hu)
KR (1) KR20000049250A (hu)
CN (1) CN1195864C (hu)
AT (1) ATE520783T1 (hu)
AU (1) AU737801B2 (hu)
BG (1) BG103334A (hu)
CA (1) CA2268271A1 (hu)
CZ (1) CZ137299A3 (hu)
GB (2) GB9621680D0 (hu)
HK (1) HK1018481A1 (hu)
HU (1) HUP0000442A3 (hu)
IL (1) IL128564A0 (hu)
NO (1) NO991742L (hu)
NZ (1) NZ334522A (hu)
PL (1) PL332876A1 (hu)
WO (1) WO1998017816A1 (hu)

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Also Published As

Publication number Publication date
EP0939827B1 (en) 2011-08-17
CZ137299A3 (cs) 1999-07-14
CN1234075A (zh) 1999-11-03
WO1998017816A1 (en) 1998-04-30
GB9903117D0 (en) 1999-04-07
GB9621680D0 (en) 1996-12-11
HK1018481A1 (en) 1999-12-24
AU737801B2 (en) 2001-08-30
NZ334522A (en) 2001-11-30
KR20000049250A (ko) 2000-07-25
PL332876A1 (en) 1999-10-25
JP2001502903A (ja) 2001-03-06
IL128564A0 (en) 2000-01-31
CN1195864C (zh) 2005-04-06
ATE520783T1 (de) 2011-09-15
BG103334A (en) 2000-06-30
NO991742D0 (no) 1999-04-13
AU4712397A (en) 1998-05-15
CA2268271A1 (en) 1998-04-30
NO991742L (no) 1999-04-13
GB2331522B (en) 2001-05-23
HUP0000442A3 (en) 2001-09-28
GB2331522A (en) 1999-05-26
EP0939827A1 (en) 1999-09-08
US6235522B1 (en) 2001-05-22

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