DE69534948D1 - Retrovirale vektoren zur expression in embryonalen zellen - Google Patents
Retrovirale vektoren zur expression in embryonalen zellenInfo
- Publication number
- DE69534948D1 DE69534948D1 DE69534948T DE69534948T DE69534948D1 DE 69534948 D1 DE69534948 D1 DE 69534948D1 DE 69534948 T DE69534948 T DE 69534948T DE 69534948 T DE69534948 T DE 69534948T DE 69534948 D1 DE69534948 D1 DE 69534948D1
- Authority
- DE
- Germany
- Prior art keywords
- vector
- retroviral
- expression
- virus
- retroviral vectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001177 retroviral effect Effects 0.000 title abstract 4
- 239000013598 vector Substances 0.000 title abstract 3
- 239000013600 plasmid vector Substances 0.000 abstract 3
- 241001529936 Murinae Species 0.000 abstract 1
- 241000713883 Myeloproliferative sarcoma virus Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241001505332 Polyomavirus sp. Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 210000002308 embryonic cell Anatomy 0.000 abstract 1
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 239000013642 negative control Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000001566 pro-viral effect Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
- C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/361,112 US5707865A (en) | 1994-12-21 | 1994-12-21 | Retroviral vectors for expression in embryonic cells |
| US361112 | 1994-12-21 | ||
| PCT/US1995/016678 WO1996019245A1 (en) | 1994-12-21 | 1995-12-19 | Retroviral vectors for expression in embryonic cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69534948D1 true DE69534948D1 (de) | 2006-05-24 |
| DE69534948T2 DE69534948T2 (de) | 2006-11-16 |
Family
ID=23420695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69534948T Expired - Fee Related DE69534948T2 (de) | 1994-12-21 | 1995-12-19 | Retrovirale vektoren zur expression in embryonalen zellen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5707865A (de) |
| EP (1) | EP0801575B1 (de) |
| JP (1) | JPH10510995A (de) |
| AT (1) | ATE323776T1 (de) |
| AU (1) | AU693317B2 (de) |
| CA (1) | CA2208210A1 (de) |
| DE (1) | DE69534948T2 (de) |
| DK (1) | DK0801575T3 (de) |
| NZ (1) | NZ300795A (de) |
| PT (1) | PT801575E (de) |
| WO (1) | WO1996019245A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996035798A1 (en) * | 1995-05-10 | 1996-11-14 | Introgene B.V. | Improved retroviral vectors, especially suitable for gene therapy |
| WO1996038545A1 (fr) * | 1995-06-02 | 1996-12-05 | Wakunaga Seiyaku Kabushiki Kaisha | Cellules generatrices de retrovirus de recombinaison |
| US7129043B1 (en) * | 1998-10-22 | 2006-10-31 | Duke University | Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease |
| US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| US6642038B1 (en) * | 1999-09-14 | 2003-11-04 | Genzyme Glycobiology Research Institute, Inc. | GlcNAc phosphotransferase of the lysosomal targeting pathway |
| DE60228082D1 (de) | 2001-05-31 | 2008-09-18 | Novartis Ag | Nten und neue liganden und pharmazeutische zusammensetzungen |
| US6905856B2 (en) * | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
| US20030124652A1 (en) * | 2001-12-21 | 2003-07-03 | Novazyme Pharmaceuticals, Inc. | Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells |
| US6800472B2 (en) * | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
| US20040009158A1 (en) * | 2002-07-11 | 2004-01-15 | Washington University | Promotion of neovascularization using bone marrow-derived endothelial-progenitor cells |
| BR112017001909A2 (pt) | 2014-07-31 | 2019-09-17 | Univ Oklahoma | proteínas, composição farmacêutica, ácido nucleico, vetores, célula, método de terapia gênica, método para tratar uma condição, uso de um vetor e uso de uma proteína de um mamífero mutante |
| CN110607394A (zh) * | 2018-06-15 | 2019-12-24 | 云舟生物科技（广州）有限公司 | 莫洛尼鼠白血病病毒滴度检测试剂盒及滴度检测方法 |
-
1994
- 1994-12-21 US US08/361,112 patent/US5707865A/en not_active Expired - Fee Related
-
1995
- 1995-12-19 CA CA002208210A patent/CA2208210A1/en not_active Abandoned
- 1995-12-19 AT AT95944182T patent/ATE323776T1/de not_active IP Right Cessation
- 1995-12-19 NZ NZ300795A patent/NZ300795A/en unknown
- 1995-12-19 DE DE69534948T patent/DE69534948T2/de not_active Expired - Fee Related
- 1995-12-19 PT PT95944182T patent/PT801575E/pt unknown
- 1995-12-19 DK DK95944182T patent/DK0801575T3/da active
- 1995-12-19 AU AU46046/96A patent/AU693317B2/en not_active Ceased
- 1995-12-19 WO PCT/US1995/016678 patent/WO1996019245A1/en active IP Right Grant
- 1995-12-19 JP JP8519995A patent/JPH10510995A/ja not_active Ceased
- 1995-12-19 EP EP95944182A patent/EP0801575B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT801575E (pt) | 2006-08-31 |
| WO1996019245A1 (en) | 1996-06-27 |
| US5707865A (en) | 1998-01-13 |
| ATE323776T1 (de) | 2006-05-15 |
| EP0801575B1 (de) | 2006-04-19 |
| AU693317B2 (en) | 1998-06-25 |
| EP0801575A4 (de) | 2001-08-16 |
| DE69534948T2 (de) | 2006-11-16 |
| EP0801575A1 (de) | 1997-10-22 |
| DK0801575T3 (da) | 2006-08-21 |
| AU4604696A (en) | 1996-07-10 |
| NZ300795A (en) | 2001-08-31 |
| JPH10510995A (ja) | 1998-10-27 |
| CA2208210A1 (en) | 1996-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |