HUP0000177A2 - Koszorúér-görccsel kapcsolatos betegségek diagnosztizálása - Google Patents
Koszorúér-görccsel kapcsolatos betegségek diagnosztizálásaInfo
- Publication number
- HUP0000177A2 HUP0000177A2 HU0000177A HUP0000177A HUP0000177A2 HU P0000177 A2 HUP0000177 A2 HU P0000177A2 HU 0000177 A HU0000177 A HU 0000177A HU P0000177 A HUP0000177 A HU P0000177A HU P0000177 A2 HUP0000177 A2 HU P0000177A2
- Authority
- HU
- Hungary
- Prior art keywords
- thymine
- gene
- diagnosis
- enos
- artery spasm
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title abstract 3
- 206010028347 Muscle twitching Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 8
- 108010075520 Nitric Oxide Synthase Type III Proteins 0.000 abstract 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 4
- 229940113082 thymine Drugs 0.000 abstract 4
- 102000008052 Nitric Oxide Synthase Type III Human genes 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229930024421 Adenine Natural products 0.000 abstract 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 2
- 206010003225 Arteriospasm coronary Diseases 0.000 abstract 2
- 208000003890 Coronary Vasospasm Diseases 0.000 abstract 2
- 229960000643 adenine Drugs 0.000 abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 201000011634 coronary artery vasospasm Diseases 0.000 abstract 2
- 229940104302 cytosine Drugs 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 108020005029 5' Flanking Region Proteins 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 101150005851 NOS gene Proteins 0.000 abstract 1
- 238000012408 PCR amplification Methods 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 108091008146 restriction endonucleases Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Electrotherapy Devices (AREA)
Abstract
A találmány tárgya kőszőrúér-görccsel kapcsőlatős betegségben szerepetjátszó gén kiszűrésére alkalmas eljárás, amely alkalmas kőszőrúér-rángásős angina pectőris diagnózisára is, amely az eddigiekbenalkalmazőtt módszerekkel nem szűrhető ki. A találmány szerintieljárásban egy vagy több nűkleőtidcserét detektálnak az endőteliálisnitrőgén-őxid-szintetáz (eNOS) génjében, amely cserék lehetnek azeNOS-gén cDNS-szekvenciájában gűaninról (G) timinre (T) a 894.helyzetben, és citőzinról (C) timinre (T) a 774. helyzetben, éslehetnek cserék az eNOS-gén 5'-végi szegélyező régiójában timinről (T)citőzinra (C) a -786. helyzetben, adeninről (A) gűaninra (G) a -922.helyzetben és timinről (T) adeninre (A) a -1468. helyzetben, valamintlehetnek cserék a kőmplementer láncők megfelelő helyzeteiben. Anűkleőtidcserék detektálását az eNOS-t kódőló cDNS-ben lévő exőn-7vagy exőn-6 kérdéses régiójának, vagy az 5'-végi szegélyező régiókérdéses helyzetét tartalmazó szekvencia amplifikálásával végzik PCRalkalmazásával, az amplifikált fragmentűmőkat az adőtt esetbenalkalmazható restrikciós enzim(m)e(kke)l emésztik, ezűtán elektrőfő-retizálják az enzimekkel emésztett fragmentűmőkat. A találmány tárgyaegy kőszőrúér-artériás görccsel kapcsőlatős betegség diagnősztizálásraalkalmas reagenskészlet is. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31950495 | 1995-11-13 | ||
| JP16876196 | 1996-06-28 | ||
| PCT/JP1996/003324 WO1997018327A1 (en) | 1995-11-13 | 1996-11-13 | Diagnosis of diseases associated with coronary twitching |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0000177A2 true HUP0000177A2 (hu) | 2000-06-28 |
| HUP0000177A3 HUP0000177A3 (en) | 2005-11-28 |
| HU226469B1 HU226469B1 (en) | 2008-12-29 |
Family
ID=26492342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000177A HU226469B1 (en) | 1995-11-13 | 1996-11-13 | Process and kit for diagnosis of diseases associated with coronary twitching |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6569618B1 (hu) |
| EP (1) | EP0875581B1 (hu) |
| JP (1) | JP3928140B2 (hu) |
| KR (1) | KR100449060B1 (hu) |
| CN (1) | CN1165628C (hu) |
| AT (1) | ATE351920T1 (hu) |
| AU (1) | AU710395B2 (hu) |
| BR (1) | BR9611309A (hu) |
| DE (1) | DE69636856T2 (hu) |
| HU (1) | HU226469B1 (hu) |
| IL (1) | IL124348A (hu) |
| NO (1) | NO323560B1 (hu) |
| NZ (1) | NZ322185A (hu) |
| RU (1) | RU2185442C2 (hu) |
| WO (1) | WO1997018327A1 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230244B1 (hu) * | 2001-06-28 | 2015-11-30 | Novartis Vaccines And Diagnostics, Inc. | Diagnosztikai esszék a B19 parvovírushoz |
| US20060177830A1 (en) * | 2004-12-02 | 2006-08-10 | Council Of Scientific & Industrial Research (Csir) | Method of detection of predisposition to emphysema in chronic obstructive pulmonary disease |
| CA2822747A1 (en) * | 2009-12-23 | 2011-06-30 | Arca Biopharma, Inc. | Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction |
| RU2469096C2 (ru) * | 2011-02-28 | 2012-12-10 | Государственное Учебно-Научное Учреждение Факультет Фундаментальной Медицины Московского Государственного Университета Имени М.В. Ломоносова | Способ определения наследственной предрасположенности к развитию инфаркта миокарда у лиц без клинических проявлений ишемической болезни сердца |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018156A1 (en) * | 1992-03-05 | 1993-09-16 | The General Hospital Corporation | Endothelial nitric oxide synthase |
-
1996
- 1996-11-13 EP EP96938453A patent/EP0875581B1/en not_active Expired - Lifetime
- 1996-11-13 NZ NZ322185A patent/NZ322185A/xx not_active IP Right Cessation
- 1996-11-13 HU HU0000177A patent/HU226469B1/hu unknown
- 1996-11-13 US US09/068,506 patent/US6569618B1/en not_active Expired - Lifetime
- 1996-11-13 CN CNB961982810A patent/CN1165628C/zh not_active Expired - Lifetime
- 1996-11-13 RU RU98111689/14A patent/RU2185442C2/ru active
- 1996-11-13 AU AU75865/96A patent/AU710395B2/en not_active Expired
- 1996-11-13 AT AT96938453T patent/ATE351920T1/de not_active IP Right Cessation
- 1996-11-13 KR KR10-1998-0702818A patent/KR100449060B1/ko not_active IP Right Cessation
- 1996-11-13 IL IL12434896A patent/IL124348A/en not_active IP Right Cessation
- 1996-11-13 WO PCT/JP1996/003324 patent/WO1997018327A1/ja active IP Right Grant
- 1996-11-13 JP JP51873697A patent/JP3928140B2/ja not_active Expired - Lifetime
- 1996-11-13 BR BR9611309A patent/BR9611309A/pt not_active IP Right Cessation
- 1996-11-13 DE DE69636856T patent/DE69636856T2/de not_active Expired - Lifetime
-
1998
- 1998-05-12 NO NO19982162A patent/NO323560B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2185442C2 (ru) | 2002-07-20 |
| NO982162L (no) | 1998-07-10 |
| US6569618B1 (en) | 2003-05-27 |
| EP0875581B1 (en) | 2007-01-17 |
| ATE351920T1 (de) | 2007-02-15 |
| IL124348A (en) | 2001-10-31 |
| AU710395B2 (en) | 1999-09-16 |
| KR100449060B1 (ko) | 2004-11-16 |
| NZ322185A (en) | 1999-05-28 |
| DE69636856D1 (de) | 2007-03-08 |
| HUP0000177A3 (en) | 2005-11-28 |
| JP3928140B2 (ja) | 2007-06-13 |
| KR19990064321A (ko) | 1999-07-26 |
| IL124348A0 (en) | 1998-12-06 |
| AU7586596A (en) | 1997-06-05 |
| DE69636856T2 (de) | 2007-10-11 |
| BR9611309A (pt) | 1999-03-02 |
| CN1165628C (zh) | 2004-09-08 |
| CN1202205A (zh) | 1998-12-16 |
| NO982162D0 (no) | 1998-05-12 |
| EP0875581A4 (en) | 2004-03-24 |
| WO1997018327A1 (en) | 1997-05-22 |
| EP0875581A1 (en) | 1998-11-04 |
| HU226469B1 (en) | 2008-12-29 |
| NO323560B1 (no) | 2007-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): BELICZAY LASZLO, S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU Representative=s name: RATHONYI ZOLTAN, S.B.G. & K., SZABADALMI UEGYV, HU |
|
| FH92 | Termination of representative |
Representative=s name: BELICZAY LASZLO, S.B.G. & K. BUDAPESTI NEMZETK, HU |