HUE045463T2 - O-metiltranszferázt használó módszerek pterosztilbén bioszintézissel való elõállításához - Google Patents

O-metiltranszferázt használó módszerek pterosztilbén bioszintézissel való elõállításához

Info

Publication number
HUE045463T2
HUE045463T2 HUE14858679A HUE14858679A HUE045463T2 HU E045463 T2 HUE045463 T2 HU E045463T2 HU E14858679 A HUE14858679 A HU E14858679A HU E14858679 A HUE14858679 A HU E14858679A HU E045463 T2 HUE045463 T2 HU E045463T2
Authority
HU
Hungary
Prior art keywords
pterostilbene
methyltransferase
methods
biosynthetic production
biosynthetic
Prior art date
Application number
HUE14858679A
Other languages
English (en)
Inventor
Mohammad Bhuiya
Yechun Wang
Xiaodan Yu
Original Assignee
Conagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc filed Critical Conagen Inc
Publication of HUE045463T2 publication Critical patent/HUE045463T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007Methyltransferases (general) (2.1.1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01095Trihydroxystilbene synthase (2.3.1.95)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y602/00Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01Acid-Thiol Ligases (6.2.1)
    • C12Y602/010124-Coumarate-CoA ligase (6.2.1.12)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE14858679A 2013-11-01 2014-11-03 O-metiltranszferázt használó módszerek pterosztilbén bioszintézissel való elõállításához HUE045463T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361898899P 2013-11-01 2013-11-01

Publications (1)

Publication Number Publication Date
HUE045463T2 true HUE045463T2 (hu) 2019-12-30

Family

ID=53005254

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14858679A HUE045463T2 (hu) 2013-11-01 2014-11-03 O-metiltranszferázt használó módszerek pterosztilbén bioszintézissel való elõállításához

Country Status (12)

Country Link
US (1) US10370683B2 (hu)
EP (1) EP3062607B1 (hu)
JP (1) JP6522640B2 (hu)
KR (1) KR102350425B1 (hu)
CN (1) CN106102454B (hu)
BR (1) BR112016009734A2 (hu)
CA (1) CA2963219C (hu)
DK (1) DK3062607T3 (hu)
ES (1) ES2745092T3 (hu)
HU (1) HUE045463T2 (hu)
MX (1) MX369206B (hu)
WO (1) WO2015066609A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102018422B1 (ko) * 2017-05-31 2019-09-04 이화여자대학교 산학협력단 재조합 벡터, 형질전환체 및 이를 이용한 테로스틸벤의 생산 방법
AU2020210969A1 (en) * 2019-01-21 2021-09-02 Food For Future S.r.l. Societa' Benefit Methylation process
CN110804618B (zh) * 2019-11-25 2022-11-11 东北电力大学 定向进化构建高效转化白藜芦醇生产松芪的romt突变体
CN112410356B (zh) * 2020-11-10 2023-07-18 杭州鑫旺途科技有限公司 来源于三叶青的白藜芦醇合酶基因rs及其应用
CN114807183B (zh) * 2021-12-06 2023-06-02 西藏自治区农牧科学院农业研究所 一种青稞矢车菊素氧甲基转移酶基因的新用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5689046A (en) 1987-09-30 1997-11-18 Bayer Aktiengesellschaft Stilbene synthase gene
GB0503657D0 (en) 2005-02-22 2005-03-30 Fluxome Sciences As Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
GB0614442D0 (en) * 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
GB0806592D0 (en) 2008-04-11 2008-05-14 Fluxome Sciences As Conversion of stilbenoids
CN102120996A (zh) * 2010-12-03 2011-07-13 西北农林科技大学 葡萄白藜芦醇-氧-甲基转移酶催化白藜芦醇生成紫檀芪的方法
KR101520912B1 (ko) * 2012-09-26 2015-05-18 한국생명공학연구원 Romt 및 sts 유전자를 이용한 식물의 스틸벤 함량을 증가시키고 화색을 변화시키는 방법
EP3039132A2 (en) * 2013-08-30 2016-07-06 Evolva SA A method for producing modified resveratrol
CN103773704B (zh) * 2013-12-25 2015-10-28 无锡新和源发酵技术研究院有限公司 一种利用o-甲基转移酶生物合成紫檀芹的方法

Also Published As

Publication number Publication date
EP3062607A4 (en) 2017-03-22
US10370683B2 (en) 2019-08-06
BR112016009734A2 (pt) 2017-09-12
CA2963219A1 (en) 2015-05-07
DK3062607T3 (da) 2019-09-23
JP2017502685A (ja) 2017-01-26
CN106102454B (zh) 2020-07-31
ES2745092T3 (es) 2020-02-27
CA2963219C (en) 2022-11-15
KR102350425B1 (ko) 2022-01-11
EP3062607A1 (en) 2016-09-07
WO2015066609A1 (en) 2015-05-07
JP6522640B2 (ja) 2019-05-29
MX369206B (es) 2019-10-31
CN106102454A (zh) 2016-11-09
US20160273006A1 (en) 2016-09-22
MX2016005717A (es) 2017-02-08
KR20160079865A (ko) 2016-07-06
EP3062607B1 (en) 2019-06-26

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